Supplementation of serum albumin is associated with improved pulmonary function: NHANES 2013–2014

Abstract

Background: The serum albumin level is reflective of the function of multiple organs, such as the liver and kidneys. However, the association between serum albumin and pulmonary function is unclear; therefore, this study aimed to determine the relationship between pulmonary function and serum albumin, including the threshold of serum albumin at the changes of the pulmonary function in the total population and in different strata of population.Methods: In this cross-sectional study, We examined the relationship between serum albumin and two independent indicators of pulmonary function: forced vital capacity (FVC) and forced expiratory volume in one second (FEV 1), using data from National Health and Nutrition Examination Survey (NHANES 2013–2014) (n = 3286). We used univariate analysis, stratified analysis, and multiple regression equation analysis to examine the correlation between serum albumin levels and FVC and FEV 1, and performed smoothed curve fitting, threshold effect, and saturation effect analysis (for stratification) to determine the threshold serum albumin level at which FVC and FEV 1 begin to change.Results: The adjusted smoothed curve fit plot showed a linear relationship between serum albu-min levels and FVC: for every 1 g/dl increase in the serum albumin level, FVC increased by 80.40 ml (11.18, 149.61). Serum albumin and FEV 1 showed a non-linear relationship. When serum al-bumin reached the inflection point (3.8 g/dl), FEV 1 increased with increasing serum albumin and the correlation coefficient β was 205.55 (140.15, 270.95).Conclusion: Serum albumin is a core indicator of liver function, and abnormal liver function has a direct impact on pulmonary function. In the total population, serum albumin levels were linearly and positively correlated with FVC. Above 3.6 g/dl, serum albumin was positively correlated with FEV 1. Based on the total population and different population strata, this study revealed a positive association between the serum albumin level and pulmonary function, and identified the threshold of serum albumin when Indicators of pulmonary function tests starts to rise, providing a new early warning indicator for people at high risk of pulmonary insufficiency and has positive implications for the prevention of combined respiratory failure in patients with liver insufficiency.

Relationship between dietary protein, serum albumin, and mortality in asthmatic populations: a cohort study

“…It has been suggested that low serum albumin levels appear to be associated with an increased risk of apnea and are potentially a predictor of future apnea ( 28 ). A cross-sectional study that included 3286 individuals found a positive correlation between serum albumin levels and lung function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV 1) ( 29 ). Decreased blood albumin levels are a well-known clinical indication of malnutrition, resulting in weakened respiratory muscles and diminished lung function ( 29 , 30 ).…”

“…A cross-sectional study that included 3286 individuals found a positive correlation between serum albumin levels and lung function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV 1) ( 29 ). Decreased blood albumin levels are a well-known clinical indication of malnutrition, resulting in weakened respiratory muscles and diminished lung function ( 29 , 30 ). Moreover, chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic respiratory inflammation and parenchymal lung damage.…”

Predictive factors and prognosis of immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer patients

“…In addition, Hu et al. found that increased ALB concentration was associated with improved lung function ( 26 ). ALB is an acute phase reactant that can show the inflammatory state of the body; a decrease in ALB may be related to the inflammatory state of the body, and these mechanisms lead to the occurrence of CIP.…”