Supplementation of the diet with the functional fiber PolyGlycoplex®is well tolerated by healthy subjects in a clinical trial

Carabin, Ioana G.; Lyon, Michael R.; Wood, Simon; Pelletier, Xavier; Donazzolo, Yves; Burdock, George A.

doi:10.1186/1475-2891-8-9

Cited by 40 publications

(52 citation statements)

References 29 publications

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“…No subjects withdrew from the study and the product was well tolerated as previously reported (Carabin et al, 2009). The control group (11 males and 16 females) had a mean age of 30.9 ± 10.8 and BMI of 22.8±2.4 kg/m 2 .…”

Section: Resultsmentioning

confidence: 70%

“…There were also significant negative correlations between ghrelin and insulin at V1 and V2 (r ¼ À0.28, P ¼ 0.038 and r ¼ À0.31, P ¼ 0.022 respectively) and between ghrelin and HOMA-IR at V1 and V2 (r ¼ À0.27, P ¼ 0.052 and r ¼ À0.28, P ¼ 0.041, respectively). Carabin et al (2009) previously showed that 3 weeks of PGX supplementation is well tolerated by healthy subjects. In this study, we report that PGX is able to increase levels of fasting PYY compared with control product and this is statistically significant in participants with a BMIo23 kg/m 2 .…”

Section: Resultsmentioning

confidence: 98%

“…The randomized, double-blind, placebo-controlled trial evaluating PGX comprised a 2-week enrollment period followed by 3 weeks of PGX or placebo supplementation (Carabin et al, 2009). Participants were healthy, nonsmoking, males and females, between the ages of 18 and 55 years with a body mass index (BMI) between 18.5 and 28.4 kg/m 2 .…”

Section: Subjectsmentioning

confidence: 99%

“…The previous clinical study by Carabin et al (2009) evaluated tolerance to PGX for 21 days to a maximum dose of 10 g per day in healthy, normal weight male and female participants and concluded it was well tolerated with minimal adverse effects similar to those commonly observed with other dietary fibers. The objective of this study was to examine the levels of the gut satiety hormones, GLP-1, PYY and total ghrelin in these participants.…”

Section: Introductionmentioning

confidence: 96%

“…A proprietary process causes strong interactions to form between konjac (glucomannan), sodium alginate and xanthan gum to produce a resultant polysaccharide complex with a level of viscosity that is higher than any currently known individual polysaccharide. The final product is a novel, soluble, highly viscous polysaccharide (functional fiber) that has been shown to be well tolerated by rodents (Matulka et al, 2009) and man (Carabin et al, 2009). Genotoxicity studies of PGX have shown no mutagenic effects using bacterial reverse mutation and mouse micronucleus assays .…”

Section: Introductionmentioning

confidence: 99%

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Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Reimer

Pelletier²,

Carabin³

et al. 2010

Eur J Clin Nutr

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Background/Objectives: A variety of dietary fibers have been shown to alter satiety hormone gene expression and secretion. The objective of this study was to examine plasma satiety hormone concentrations in healthy subjects consuming either PolyGlycopleX (PGX) or control (skim milk powder) for 21 days. Subjects/Methods: A randomized, double-blind, placebo-controlled clinical study was conducted in 54 healthy male and female adults. Participants consumed 5 g per day of PGX or control for 1 week followed by 2 additional weeks of 10 g per day of assigned product (n ¼ 27 per group). Primary outcomes measured at three visits (V1, V2 and V3) were plasma active glucagon-like peptide-1 (GLP-1) total ghrelin, peptide YY (PYY) and insulin.Results: There was a significant effect of visit for fasting PYY with control participants experiencing decreased PYY levels over time while PGX prevented this decline. When stratified by body mass index (BMI), PGX increased fasting PYY levels from week 1 to week 3 compared with control in participants with BMI o23 kg/m 2 . There was a significant effect of visit for fasting ghrelin with levels decreasing in both PGX and control groups over time. No differences were detected in fasting GLP-1 levels. Although there was a 14% reduction in fasting insulin between V1 and V3 with PGX this was not significantly different from control. Conclusions: PGX is a highly viscous, functional fiber that modifies satiety hormone secretion in healthy adults. Its' potential to act similarly in overweight adults warrants investigation.

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Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 98%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Reimer

Pelletier²,

Carabin³

et al. 2010

Eur J Clin Nutr

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Changes in Visceral Adiposity and Serum Cholesterol with a Novel Viscous Polysaccharide in Japanese Adults with Abdominal Obesity

Reimer

Yamaguchi

Eller

et al. 2013

Obesity

Self Cite

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Objective: Evidence supports the role of dietary fiber in improving metabolic health. PolyGlycopleX V R (PGX V R ), a viscous functional polysaccharide improves lipidemia and glycemia in healthy adults. Our objective was to examine the effects of PGX V R on risk factors associated with the metabolic syndrome in Japanese adults with abdominal obesity. Design and Methods: Sixty four subjects assigned to 14 weeks of 15 g day À1 of PGX V R or placebo were assessed in a randomized, double-blind, placebo-controlled, parallel group trial. At week 0 and 14, primary outcome measures were serum lipids, abdominal adiposity, glucose tolerance and blood pressure. Results: Total and LDL cholesterol were reduced at week 14 with PGX V R but not placebo (P < 0.05). The reduction in waist circumference at week 14 was greater with PGX V R versus placebo (P < 0.05). In females, abdominal visceral fat was decreased to a greater extent with PGX V R versus placebo (P < 0.05). While glucose tolerance worsened with placebo over time, PGX V R reduced glucose total area under the curve from week 0 to 6 (P ¼ 0.039). Serum concentrations of resistin and IL6 increased slightly in placebo and decreased slightly with PGX V R . Conclusions: PGX V R is a functional fiber that shows promise in reducing risk factors related to the metabolic syndrome in Japanese adults with abdominal obesity.

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Development of probiotic yogurt: effect of strain combination on nutritional, rheological, organoleptic and probiotic properties

et al. 2020

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Supplementation of the diet with the functional fiber PolyGlycoplex®is well tolerated by healthy subjects in a clinical trial

Cited by 40 publications

References 29 publications

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Changes in Visceral Adiposity and Serum Cholesterol with a Novel Viscous Polysaccharide in Japanese Adults with Abdominal Obesity

Development of probiotic yogurt: effect of strain combination on nutritional, rheological, organoleptic and probiotic properties

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