Supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevents neonatal vitamin K deficiency

Cornelissen, M.; Steegers‐Theunissen, R.P.M.; Kollée, L.A.A.; Eskes, T.K.A.B.; Motohara, Kunihiko; Monnens, L.A.H.

doi:10.1016/s0002-9378(12)90839-x

Cited by 87 publications

(39 citation statements)

References 16 publications

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“…Their use can result in hemorrhagic disease of the newborn leading to intraparenchymal and intracerebral hemorrhage [21] could be the probable hypothesis for the haemorrhagic spots found on surfaces of the liver . …”

Section: Discussionmentioning

confidence: 99%

Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice

Singh¹,

Pandey²,

Dwivedi³

et al. 2017

IOSR JDMS

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Section: Discussionmentioning

confidence: 99%

Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice

Singh¹,

Pandey²,

Dwivedi³

et al. 2017

IOSR JDMS

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“…Recent reports sug gest that these babies may have an increased risk of develop mental delay or specific learning disabilities. [53][54][55] Most of the studies are retrospective in design and do not control for all other variables. When 249 mother-child pairs were evaluated with a series of neuropsychological tests (children were 6-16 years old), those exposed to VPA had a significantly lower ver bal IQ when compared with those with exposure to other AEDs or those not exposed to any AED.…”

Section: Malformationsmentioning

confidence: 99%

“…Administration of vitamin K 1 to the mother can help prevent hemorrhagic disease of the newborn. [55] It is generally recommended that pregnant WWE on enzyme-in ducing AEDs should be prescribed vitamin K 1 (10 mg/day) during the last month of pregnancy. These neonates should receive the customary dose of injection vitamin K 1 mg on day 1.…”

Section: Counseling the Family When An Abnormality Is Detectedmentioning

confidence: 99%

Management of Epilepsy and Pregnancy

Thomas

2013

Epilepsy in Women

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“…It is not clear whether PIVKA production is caused by vitamin K deficiency only or by liver immaturity? Nevertheless, administration of vitamin K is recommended in the prophylactic treatment of perinatal bleeding in women undergoing antiepileptic therapy [9].…”

Section: Are There Fetal Forms Of the Coagulation Factors?mentioning

confidence: 99%

Procoagulants and anticoagulants in fetal blood. A literature survey.

Uszyński

Uszyński²,

Szymański³

2010

Folia Histochem Cytobiol.

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Abstract:In intrauterine life, hemostasis is maintained by the same components as in extrauterine life (blood platelets, coagulation and fibrinolysis systems, involvement of the vascular wall); in the fetus, however, these components show significant differences of a quantitative/qualitative nature. In the present study, we surveyed the literature on the coagulation system in the fetus. We focused on the velocity of development of the coagulation system, being reflected in the increased concentration of all procoagulants and anticoagulants (a rise from approximately 20% in the middle of pregnancy to about 60% or more in the period of labor; exceptions: factors V,VIII and XIII which in the labor period reach the adult level) and screening test results (prothrombin time, aPTT -activated prothrombin time, and thrombin time). Reference values were given for the 19-38 weeks of pregnancy and the labor term. Biochemical features of fetal fibrinogen and PIVKA factors were also discussed. The role of activated protein C (APC) in the maintenance of balance between procoagulants and anticoagulants was postulated as well as the role of APC in the formation of thrombin activatable fibrinolysis inhibitor (TAFI).

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Supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevents neonatal vitamin K deficiency

Cited by 87 publications

References 16 publications

Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice

Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice

Management of Epilepsy and Pregnancy

Procoagulants and anticoagulants in fetal blood. A literature survey.

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