Supplementation with Calcium and Short-Chain Fructo-Oligosaccharides Affects Markers of Bone Turnover but Not Bone Mineral Density in Postmenopausal Women

Slevin, Mary; Allsopp, Philip J.; Magee, Pamela; Bonham, Maxine P.; Naughton, Violetta R.; Strain, JJ; Duffy, Maresa; Wallace, Julie; Sorley, Emeir M. Mc

doi:10.3945/jn.113.188144

Cited by 69 publications

(60 citation statements)

References 41 publications

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“…Similarly, 4-weeks of FOS or DFAIII decreased resorption markers in gastrectomized rats (25). Consistent with the latter rodent studies, a randomized intervention study in post-menopausal women (average age 61) demonstrated that 24 months of short-chained FOS treatment reduced serum and urine bone turnover markers (42). …”

Section: Introductionmentioning

confidence: 60%

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Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

McCabe

Britton

Parameswaran

2015

Curr Osteoporos Rep

189

127

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Recent advances in our understanding of how the intestinal microbiome contributes to health and disease have generated great interest in developing strategies for modulating the abundance of microbes and/or their activity to improve overall human health and prevent pathologies such as osteoporosis. Bone is an organ that the gut has long been known to regulate through absorption of calcium, the key bone mineral. However, it is clear that modulation of the gut and its microbiome can affect bone density and strength in a variety of animal models (zebra fish, rodents, chicken) and humans. This is demonstrated in studies ablating the microbiome through antibiotic treatment or using germ-free mouse conditions as well as in studies modulating the microbiome activity and composition through prebiotic and/or probiotic treatment. This review will discuss recent developments in this new and exciting area.

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Section: Introductionmentioning

confidence: 60%

“…As expected, short studies do not show changes in bone density, but a one year FOS treatment study was long enough to detect an increase in whole body bone mineral density in adolescent girls (30). Similarly, one year of FOS treatment reduced bone loss in post-menopausal women (42). …”

Section: Introductionmentioning

confidence: 99%

Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

McCabe

Britton

Parameswaran

2015

Curr Osteoporos Rep

189

127

View full text Add to dashboard Cite

show abstract

“…The only cross-sectional observational study (21) , to our knowledge, reported that dietary fiber was positively related to forearm BMD in children but not in adolescents. However, results from clinical trials in postmenopausal women are inconsistent: Although a positive association has been shown between fiber intake and calcium absorption (22–25) , this does not translate to change in BMD (26,27) . Different directions of bone turnover markers were also reported (24,25,27) .…”

Section: Introductionmentioning

confidence: 99%

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study

Felson

Kiel

et al. 2017

Journal of Bone and Mineral Research

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Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between genders. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts and legumes) and bone loss at the femoral neck, trochanter and lumbar spine (L2–4) in older men and women. In the Framingham Offspring Study, at baseline (1996–2001), diet was assessed using the Willett food frequency questionnaire and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Follow-up BMD was measured in 2001–2005 and 2005–2008 among 792 men (mean age, 58.1yr; BMI, 28.6kg/m2) and 1,065 women (57.3yr; 27.2kg/m2). We used sex-specific generalized estimating equations in multivariable regressions to estimate the difference (β) of annualized BMD change in percent (%ΔBMD) at each skeletal site per 5 g/d increase in dietary fiber. We further estimated the adjusted mean for bone loss (annualized %ΔBMD) among participants in each higher quartile (Q2, Q3 or Q4) compared with those in the lowest quartile (Q1) of fiber intake. Higher dietary total fiber (β=0.06, p=0.003) and fruit fiber (β=0.04, p=0.008) was protective against bone loss at the femoral neck in men but not in women. When examined in quartiles, men in Q2–Q4 of total fiber had significantly less bone loss at the femoral neck versus those in Q1 (all p<0.04). Fiber from vegetables appeared to be protective against spine bone loss in women but not men. There were no associations with cereal fiber or nut and legume fiber and bone loss in men or women. Our findings suggest that higher dietary fiber may modestly reduce bone loss in men at the hip.

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“…The prebiotic is fermented in the gut, causing a drop in the pH of the lumen to such an extent that previously insoluble calcium phosphate will dissolve. This plays a beneficial role in bone mineral density 50 . The fermentation of FOS releases short-chain fatty acids and lactic acid, which cause the drop in pH.…”

Section: Health-focused Researchmentioning

confidence: 99%

Recent advances in microbial fermentation for dairy and health

et al. 2017

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Microbial fermentation has been used historically for the preservation of foods, the health benefits of which have since come to light. Early dairy fermentations depended on the spontaneous activity of the indigenous microbiota of the milk. Modern fermentations rely on defined starter cultures with desirable characteristics to ensure consistency and commercial viability. The selection of defined starters depends on specific phenotypes that benefit the product by guaranteeing shelf life and ensuring safety, texture, and flavour. Lactic acid bacteria can produce a number of bioactive metabolites during fermentation, such as bacteriocins, biogenic amines, exopolysaccharides, and proteolytically released peptides, among others. Prebiotics are added to food fermentations to improve the performance of probiotics. It has also been found that prebiotics fermented in the gut can have benefits that go beyond helping probiotic growth. Studies are now looking at how the fermentation of prebiotics such as fructo-oligosaccharides can help in the prevention of diseases such as osteoporosis, obesity, and colorectal cancer. The potential to prevent or even treat disease through the fermentation of food is a medically and commercially attractive goal and is showing increasing promise. However, the stringent regulation of probiotics is beginning to detrimentally affect the field and limit their application.

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Supplementation with Calcium and Short-Chain Fructo-Oligosaccharides Affects Markers of Bone Turnover but Not Bone Mineral Density in Postmenopausal Women

Cited by 69 publications

References 41 publications

Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study

Recent advances in microbial fermentation for dairy and health

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