Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows

Singh, Shiva P.; Häußler, Susanne; Heinz, Johanna F.L.; Saremi, B.; Mielenz, B.; Rehage, J.; Dänicke, Sven; Mielenz, M.; Sauerwein, H.

doi:10.1016/j.ygcen.2013.12.008

Cited by 29 publications

(29 citation statements)

References 61 publications

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“…In agreement with our findings, Singh et al. () observed elevated insulin concentrations in CLA‐supplemented cows, whereas glucose concentrations were less affected. A deeper investigation of glucose metabolism of CLA‐supplemented transition dairy cows with respect to the dynamics and turnover characteristics is necessary.…”

Section: Discussionsupporting

confidence: 93%

Hyperglycaemia in transition dairy cows: Effects of lactational stage and conjugated linoleic acid supplementation on glucose metabolism and turnover

Grossen-Rösti

Kessler

Tröscher

et al. 2017

Animal Physiology Nutrition

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Supplementing conjugated linoleic acid (CLA) is supposed to spare glucose due to the milk fat-depressing effect of the trans-10, cis-12 CLA isomer, and allows repartitioning nutrients despite an energy deficiency in early lactation. However, there is still a lack of knowledge in terms of the dynamic pattern of the glucose turnover in transition dairy cows. We hypothesized that dairy cows supplemented with CLA have an altered rate of glucose turnover and insulin sensitivity during early lactation. We conducted three consecutive hyperglycaemic clamps (HGC) in weeks -2, +2 and +4 relative to parturition in Holstein cows supplemented daily either with 70 g of lipid-encapsulated CLA (6.8 g trans-10, cis-12 and 6.6 g of the cis-9, trans-11 CLA isomer; CLA; n = 11) or with 56 g of control fat (CON; n = 11). From week -3 up to week +4 relative to parturition, milk yield and dry matter intake (DMI) were recorded daily, while body weight (BW) and milk composition were obtained once weekly. Blood samples were taken once weekly and every 30 min during the HGC. Plasma was analysed for concentrations of glucose, fatty acids (FFA), beta-hydroxybutyrate (BHB), insulin, triglycerides and cholesterol. The CLA supplementation did not affect performance and metabolic parameters except for BHB and cholesterol. Furthermore, insulin concentrations and insulin sensitivity were affected by treatment. During the HGC in early lactation, insulin response was lower and decrease in FFA and BHB greater compared with the HGC in week -2 although glucose target concentration achieved during the steady-state period was similar for all three HGC. Our findings in terms of insulin and cholesterol suggest that body reserves are preserved through CLA feeding without restraining animal's performance. Furthermore, CLA effects on cholesterol and triglyceride concentrations indicated beneficial effects on hepatic lipid export contributing to an improved efficiency of prevailing metabolites in circulation.

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Section: Discussionsupporting

confidence: 93%

Hyperglycaemia in transition dairy cows: Effects of lactational stage and conjugated linoleic acid supplementation on glucose metabolism and turnover

Grossen-Rösti

Kessler

Tröscher

et al. 2017

Animal Physiology Nutrition

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“…The presence of adiponectin has been documented for human milk (Martin et al, 2006;Bronskỳ et al, 2012). The concentrations of adiponectin in mature human milk (around 20 ng/mL; Bronskỳ et al, 2012) are far below the ones we recently reported for cow milk (610 ng/mL; Singh et al, 2014b), albeit the blood concentrations are comparable in the 1-to 2-digit μg/mL range in both species (Højlund et al, 2006;Singh et al, 2014a). In view of adiponectin's metabolic functions and of the expression of adiponectin receptor 1 in the small intestine of neonatal mice (Zhou et al, 2005), milk adiponectin may play an important role in infant development, both locally and systemically and may also exert a trajectory effect during later ages (Woo et al, 2012).…”

Section: Introductioncontrasting

confidence: 62%

The rapid increase of circulating adiponectin in neonatal calves depends on colostrum intake

Kesser

Hill

Heinz

et al. 2015

Journal of Dairy Science

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Adiponectin, an adipokine, regulates metabolism and insulin sensitivity. Considering that the transplacental transfer of maternal proteins of high molecular weight is hindered in ruminants, this study tested the hypothesis that the blood concentration of adiponectin in neonatal calves largely reflects their endogenous synthesis whereby the intake of colostrum might modify the circulating concentrations. We thus characterized the adiponectin concentrations in neonatal and young calves that were fed either colostrum or formula. Three trials were performed: in trial 1, 20 calves were all fed colostrum for 3 d, and then formula until weaning. Blood samples were collected on d 0 (before colostrum feeding), and on d 1, 3, 11, 22, 34, 43, 52, 70, 90, and 108 postnatum. In trial 2, 14 calves were studied for the first 4 d of life. They were fed colostrum (n=7) or formula (n=7), and blood samples were taken right after birth and before each morning feeding on d 2, 3, and 4. In trial 3, calves born preterm (n=7) or at term received colostrum only at 24 h postnatum. Blood was sampled at birth, and before and 2 h after feeding. Additionally, allantoic fluid and blood from 4 Holstein cows undergoing cesarean section were sampled. Adiponectin was quantified by ELISA. In trial 1, the serum adiponectin concentrations recorded on d 3 were 4.7-fold higher than before colostrum intake. The distribution of the molecular weight forms of adiponectin differed before and after colostrum consumption. In trial 2, the colostrum group had consistently greater plasma adiponectin concentrations than the formula group after the first meal. In trial 3, the preterm calves tended to have lower concentrations of plasma adiponectin than the term calves at birth and before and 2 h after feeding. Furthermore, the adiponectin concentrations were substantially lower in allantoic fluid than in the sera from neonatal calves and from cows at parturition. Our results show that calves are born with very low blood concentrations of adiponectin and placental transfer of adiponectin to the bovine fetus is unlikely. In conclusion, colostrum intake is essential for the postnatal increase of circulating adiponectin in newborn calves.

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“…Our results are limited to bulls because the age range of the heifers here was 15 to 28 months. However, when comparing cows up to four lactations from previous studies, the AdipoQ serum concentrations were greater in multiparous than primiparous lactating cows from Day-21 prepartum until Day 252 during lactation [33]. One possible explanation for the increase of AdipoQ serum concentrations with age in bulls may be changing sex hormone concentrations over the life span.…”

Section: Age-dependent Differences In Adipoq Concentrationsmentioning

confidence: 81%

Characterization of adiponectin concentrations and molecular weight forms in serum, seminal plasma, and ovarian follicular fluid from cattle

Heinz

Singh

Janowitz³

et al. 2015

Theriogenology

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Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows

Cited by 29 publications

References 61 publications

Hyperglycaemia in transition dairy cows: Effects of lactational stage and conjugated linoleic acid supplementation on glucose metabolism and turnover

Hyperglycaemia in transition dairy cows: Effects of lactational stage and conjugated linoleic acid supplementation on glucose metabolism and turnover

The rapid increase of circulating adiponectin in neonatal calves depends on colostrum intake

Characterization of adiponectin concentrations and molecular weight forms in serum, seminal plasma, and ovarian follicular fluid from cattle

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