Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model

Rusbana, Tubagus Bahtiar; Agista, Afifah Zahra; Saputra, Wahyu Dwi; Ohsaki, Yusuke; Watanabe, Kouichi; Ardiansyah, Ardy; Budijanto, Slamet; Koseki, Takuya; Aso, Hisashi; Komai, Michio; Shirakawa, Hitoshi

doi:10.3390/nu12082409

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…Diabetic skeletal muscle atrophy, defined by decreased skeletal, and muscular strength, and mass, is a common complication of diabetes called diabetic myopathy [1]. Diabetic myopathy contributes to the development of complications and other comorbidities of diabetes [4] and is considered a significant clinical challenge associated with a reduced quality of life [5].…”

Section: Introductionmentioning

confidence: 99%

Molecular and cellular effects of gold nanoparticles treatment in experimental diabetic myopathy

Al-Shwaheen

Aljabali

Alomari

et al. 2022

Heliyon

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Section: Introductionmentioning

confidence: 99%

Molecular and cellular effects of gold nanoparticles treatment in experimental diabetic myopathy

Al-Shwaheen

Aljabali

Alomari

et al. 2022

Heliyon

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“…Previous studies showed that 5% of FRB supplementation could attenuate metabolic syndrome [ 25 ] and obesity [ 35 ]. Muscle atrophy [ 26 ] and intestinal inflammatory disorders [ 28 ] were also prevented after 10% of RB fermented by A. kawachii and Lactobacillus sp. In the present study, rats in the HF+1% FRB and 5% FRB groups showed significantly lower hepatic IL-1β levels, a decreasing trend of final BWs, plasma leptin levels, and hepatic TNF-α levels compared to the HF group.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, RB has gradually been developed into a low-cost and functional food ingredient. The potential protective effects of FRB against metabolic disorders were investigated in several studies, including METS, hypertension [ 25 ], diabetes [ 26 ], inflammatory bowel disease (IBD) [ 27 , 28 ], and tumor progression [ 29 ], which validated the functional properties of FRB in improving lipid metabolism impairment, regulating glucose levels [ 25 ], suppressing oxidative stress [ 28 ], attenuating inflammatory responses [ 26 , 28 ], and affecting the gut microbiota [ 27 ]. These effects are also involved in regulating NAFLD development.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding

Chen

Chiu

et al. 2022

Plants

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The purpose of this study was to investigate the protective effects of the water extract of fermented rice bran (FRB) on liver damage and intestinal injury in old rats fed a high-fat (HF) diet. Rice bran (RB) was fermented with Aspergillus kawachii, and FRB was produced based on a previous study. Male Sprague Dawley rats at 36 weeks of age were allowed free access to a standard rodent diet and water for 8 weeks of acclimation then randomly divided into four groups (six rats/group), including a normal control (NC) group (normal diet), HF group (HF diet; 60% of total calories from fat), HF + 1% FRB group (HF diet + 1% FRB w/w), and HF + 5% FRB group (HF diet + 5% FRB w/w). It was found that the antioxidant ability of FRB was significantly increased when compared to RB. After 8 weeks of feeding, the HF group exhibited liver damage including an increased non-alcoholic fatty liver disease score (hepatic steatosis and inflammation) and higher interleukin (IL)-1β levels, while these were attenuated in the FRB-treated groups. Elevated plasma leptin levels were also found in the HF group, but the level was down-regulated by FRB treatment. An altered gut microbiotic composition was observed in the HF group, while beneficial bacteria including of the Lactobacillaceae and Lachnospiraceae had increased after FRB supplementation. In conclusion, it was found that FRB had higher anti-oxidative ability and showed the potential for preventing liver damage induced by a HF diet, which might be achieved through regulating imbalanced adipokines and maintaining a healthier microbiotic composition.

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“…The change in muscle tissues was observed under a microscope (original magnification 200×). The size of fibers was measured in the image using the ImageJ software () and presented the mean cross-sectional area of the muscle fibers …”

Section: Methodsmentioning

confidence: 99%

Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation

et al. 2021

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Type 2 diabetes is the most common type of diabetes and causes a decline in muscle quality. In this study, we investigated the effects of the root extract of Morinda officinalis (MORE) on skeletal muscle damage in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetes and the expression of myogenic and biogenesis regulatory proteins in C2C12 myoblast differentiation. An in vivo model comprised C57BL/6N mice fed HFD for 8 weeks, followed by a single injection of STZ at 120 mg/kg. MORE was administered at 100 and 200 mg/kg once daily (p.o.) for 4 weeks. The changes in body weight, calorie intake, and serum levels of glucose, insulin, total cholesterol (TCHO), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) were investigated in diabetic mice. The histological changes in the gastrocnemius muscle were observed by H&E staining, and then the myofiber size was measured. The expression of the myogenic (MHC, myogenin, and MyoD) and biogenesis (PGC-1α, SIRT1, NRF1, and TFAM) regulatory proteins was examined in the muscle tissues and differentiated C2C12 myoblasts by Western blot, respectively. The administration of MORE at 200 mg/kg in mice with HFD/STZ-induced diabetes significantly reduced weight gains, calorie intake, insulin resistance, and serum levels of glucose, TCHO, LDL-C, AST, and ALT. MORE administration at 100 and 200 mg/kg significantly increased serum insulin and HDL-C levels in diabetic mice. In addition, MORE significantly increased the expression of MHC, myogenin, MyoD, PGC-1α, SIRT1, NRF1, and TFAM in muscle tissues as well as increased the myofiber size in diabetic mice. In C2C12 myoblast differentiation, MORE treatment at 0.5, 1, and 2 mg/mL significantly increased the expression of myogenic and biogenesis regulatory proteins in a dose-dependent manner. MORE improves diabetes symptoms in mice with HFD/STZ-induced diabetes by improving muscle function. This suggests that MORE could be used to prevent or treat diabetes along with muscle disorders.

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Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model

Cited by 15 publications

References 47 publications

Molecular and cellular effects of gold nanoparticles treatment in experimental diabetic myopathy

Molecular and cellular effects of gold nanoparticles treatment in experimental diabetic myopathy

Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding

Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation

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