Supplementation with fruit and vegetable extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population

Smith, Micah J.; Inserra, Paula; Watson, Ronald R.; Wise, John A.; O’Neill, Kim L.

doi:10.1016/s0271-5317(99)00107-4

Cited by 34 publications

(21 citation statements)

References 25 publications

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“…Of these, eight (10 reports) had a parallel design [15,17,21,22,26,[29][30][31][32][33], and the remainder were randomized crossover studies. Thirteen trials contained only healthy participants, one (two reports) included healthy elderly patients [13,14], one study used overweight but otherwise healthy subjects [18], one included prehypertensive and hypertensive patients [27], one included healthy nonsmokers and light smokers [28], and one trial (two reports) used a combination of healthy and human immunodeficiency virus (HIV)-positive participants [23,24]. In all of the trials, subjects were instructed to follow their habitual ad libitum diets.…”

Section: Study Descriptionmentioning

confidence: 99%

“…The first was a FV or FVB (FV concentrate including berry concentrate) capsule (Juice Plusþ; NSA, Collierville, TN), which was used in 17 trials (20 reports) [12][13][14][15][16][17][18][19][20][21][22][25][26][27][28][29][30][31][32][33]. These capsules were derived through a proprietary method and consisted of blended FV juice powder concentrate ( Table 2).…”

Section: Study Descriptionmentioning

confidence: 99%

“…Therefore, strengthening the free radical defense system through dietary antioxidants, such as carotenoids and vitamins C and E, may be of importance. Eleven trials (13 reports) [12][13][14][16][17][18][19]21,22,[25][26][27]31] published between 1996 and 2010 examined the bioavailability of antioxidants administered in the form of FV capsules ( Table 4).…”

Section: Serum Antioxidant Concentrationsmentioning

confidence: 99%

“…The study of Smith et al, which also reported no improvements in vitamin E levels [14], included a subgroup (n ¼ 20) from the study by Inserra et al (n ¼ 53) [13]. The lack of effect may, therefore, be a result of insufficient statistical power to detect a change.…”

Section: Journal Of the American College Of Nutrition 287mentioning

confidence: 99%

“…Eleven trials (13 reports) [12,14,16,17,19,21,22,25,26,[28][29][30]33] examined the effect of FV capsules on various markers of oxidative stress related to protein, lipid, or DNA oxidation ( Table 5).…”

Section: Oxidative Stressmentioning

confidence: 99%

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Health Effects of Mixed Fruit and Vegetable Concentrates: A Systematic Review of the Clinical Interventions

Esfahani

Wong²,

Truan³

et al. 2011

Journal of the American College of Nutrition

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Diets rich in fruits and vegetables (FV) have been associated with a reduced risk of chronic disease, including cardiovascular disease. Unfortunately, public health campaigns to increase FV intake have had limited success. A number of mixed concentrated FV products have been studied, which may help certain individuals improve nutrient status. However, the possible health benefits of FV supplements have not been systematically reviewed. We, therefore, undertook a systematic search of MEDLINE and EMBASE to identify clinical interventions that examined the effect of commercially available concentrated mixed FV supplements on cardiovascular disease risk factors. Twenty-two reports, which used commercially available products, were identified. None of the studies reported any serious adverse effects. Overall, daily consumption of FV supplements significantly increased serum concentrations of the major antioxidant provitamins and vitamins found in plant foods (β-carotene, vitamins C and E) and folate. Functional changes, such as reduced serum homocysteine and markers of protein, lipid, and DNA oxidation, were also reported; in addition, the health advantages on markers of inflammation, immunity, and endothelial function are promising. Limitations of the available studies were related to the diversity of studies conducted with respect to design and study population and the variability in the measured outcomes and assays utilized. While mixed FV supplements may serve as an efficacious complement for individuals who have difficulty achieving their daily FV intake requirement, further research on additional retail preparations is warranted. Key teaching points: Mixed fruit and vegetable supplements produced from plant foods may serve as an efficacious complement to the habitual diet in individuals who have suboptimal intake or variety of nutrient-dense fruits and vegetables. Current research indicates that fruit and vegetable concentrates significantly increase serum levels of antioxidant provitamins and vitamins (β-carotene, vitamins C and E) and folate and reduce homocysteine and markers of oxidative stress. Mechanistic studies and larger, randomized, placebo-controlled double-blind trials in both healthy and high-risk populations are necessary to better understand the health effects of these supplements.

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Section: Study Descriptionmentioning

confidence: 99%

Section: Study Descriptionmentioning

confidence: 99%

Section: Serum Antioxidant Concentrationsmentioning

confidence: 99%

Section: Journal Of the American College Of Nutrition 287mentioning

confidence: 99%

Section: Oxidative Stressmentioning

confidence: 99%

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Health Effects of Mixed Fruit and Vegetable Concentrates: A Systematic Review of the Clinical Interventions

Esfahani

Wong²,

Truan³

et al. 2011

Journal of the American College of Nutrition

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Effects of a traditional fermented grape‐based drink ‘hardaliye’ on antioxidant status of healthy adults: a randomized controlled clinical trial

et al. 2013

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Ameliorating reactive oxygen species-induced in vitro lipid peroxidation in brain, liver, mitochondria and DNA damage by Zingiber officinale Roscoe

Ajith

2010

Indian J Clin Biochem

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Iron is an essential nutrient for a number of cellular activities. However, excess cellular iron can be toxic by producing reactive oxygen species (ROS) such as superoxide anion (O(2) (-)) and hydroxyl radical (HO(·)) that damage proteins, lipids and DNA. Mutagenic and genotoxic end products of lipid peroxidation can induce the decline of mitochondrial respiration and are associated with various human ailments including aging, neurodegenerative disorders, cancer etc. Zingiber officinale Roscoe (ginger) is a widely used spice around the world. The protective effect of aqueous ethanol extract of Z. officinale against ROS-induced in vitro lipid peroxidation and DNA damage was evaluated in this study. The lipid peroxidation was induced by hydroxyl radical generated from Fenton's reaction in rat liver and brain homogenates and mitochondrial fraction (isolated from rat liver). The DNA protection was evaluated using H(2)O(2)-induced changes in pBR-322 plasmid and Fenton reaction-induced DNA fragmentation in rat liver. The results indicated that Z. officinale significantly (P<0.001) protected the lipid peroxidation in all the tissue homogenate/mitochondria. The extract at 2 and 0.5 mg/ml could protect 92 % of the lipid peroxidation in brain homogenate and liver mitochondria respectively. The percent inhibition of lipid peroxidation at 1mg/ml of Z. officinale in the liver homogenate was 94 %. However, the extract could partially alleviate the DNA damage. The protective mechanism can be correlated to the radical scavenging property of Z. officinale. The results of the study suggest the possible nutraceutical role of Z. officinale against the oxidative stress induced human ailments.

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Supplementation with fruit and vegetable extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population

Cited by 34 publications

References 25 publications

Health Effects of Mixed Fruit and Vegetable Concentrates: A Systematic Review of the Clinical Interventions

Health Effects of Mixed Fruit and Vegetable Concentrates: A Systematic Review of the Clinical Interventions

Effects of a traditional fermented grape‐based drink ‘hardaliye’ on antioxidant status of healthy adults: a randomized controlled clinical trial

Ameliorating reactive oxygen species-induced in vitro lipid peroxidation in brain, liver, mitochondria and DNA damage by Zingiber officinale Roscoe

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