Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Kim, M.; Lee, Y. J.; Song, H-T; Shim, Jae-Jung; Chang, Dong Hoon; Yu, Won Kyu; Lee, S.-H.; Lee, Joong Ho

doi:10.1111/jhn.12447

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…As chronic inflammation in CF patients could lower IGF-1 concentration, NO production could be influenced as well as the possibility that respiratory impairment might rise as IGF-1 levels decrease [ 98 ]. In 56 community-dwelling elderly, a two-week supplementation of energy and protein resulted in elevated IGF-1 concentration and the lowering of inflammation markers interleukin 6 and tumor necrosis-factor α [ 99 ]. In pediatric CF patients, growth hormone treatment without a prior growth hormone deficit lead to the improvement of growth, nutritional status, protein retention and IGF-1 levels [ 100 , 101 ].…”

Section: Discussionmentioning

confidence: 99%

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

Brinkmann

Hanusch

Ballmann

et al. 2020

JCM

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Cystic fibrosis (CF; OMIM 219700) is a rare genetic disorder caused by a chloride channel defect, resulting in lung disease, pancreas insufficiency and liver impairment. Altered L-arginine (Arg)/nitric oxide (NO) metabolism has been observed in CF patients’ lungs and in connection with malnutrition. The aim of the present study was to investigate markers of the Arg/NO pathway in the plasma and urine of CF patients and to identify possible risk factors, especially associated with malnutrition. We measured the major NO metabolites nitrite and nitrate, Arg, a semi-essential amino acid and NO precursor, the NO synthesis inhibitor asymmetric dimethylarginine (ADMA) and its major urinary metabolite dimethylamine (DMA) in plasma and urine samples of 70 pediatric CF patients and 78 age-matched healthy controls. Biomarkers were determined by gas chromatography–mass spectrometry and high-performance liquid chromatography. We observed higher plasma Arg (90.3 vs. 75.6 µM, p < 0.0001), ADMA (0.62 vs. 0.57 µM, p = 0.03), Arg/ADMA ratio (148 vs. 135, p = 0.01), nitrite (2.07 vs. 1.95 µM, p = 0.03) and nitrate (43.3 vs. 33.1 µM, p < 0.001) concentrations, as well as higher urinary DMA (57.9 vs. 40.7 µM/mM creatinine, p < 0.001) and nitrate (159 vs. 115 µM/mM creatinine, p = 0.001) excretion rates in the CF patients compared to healthy controls. CF patients with pancreatic sufficiency showed plasma concentrations of the biomarkers comparable to those of healthy controls. Malnourished CF patients had lower Arg/ADMA ratios (p = 0.02), indicating a higher NO synthesis capacity in sufficiently nourished CF patients. We conclude that NO production, protein-arginine dimethylation, and ADMA metabolism is increased in pediatric CF patients. Pancreas and liver function influence Arg/NO metabolism. Good nutritional status is associated with higher NO synthesis capacity and lower protein-arginine dimethylation.

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Section: Discussionmentioning

confidence: 99%

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

Brinkmann

Hanusch

Ballmann

et al. 2020

JCM

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“…The blood samples were centrifuged to obtain plasma and serum samples, which were then stored at − 70 °C. The levels of serum-fasting glucose, insulin, triglycerides (TGs), total cholesterol, and high-density lipoprotein (HDL) cholesterol were measured [ 15 ]. The IR and low-density lipoprotein (LDL) cholesterol levels were calculated using the equations of homeostatic model assessment (HOMA) and the Friedewald formula, respectively: HOMA-IR = [fasting insulin (μIU/mL) × fasting glucose (mg/dL)]/405; Friedewald formula: LDL cholesterol = total cholesterol – [HDL cholesterol + (TG/5)].…”

Section: Methodsmentioning

confidence: 99%

Effect of weight loss on circulating fatty acid profiles in overweight subjects with high visceral fat area: a 12-week randomized controlled trial

Lee

Yoo

et al. 2018

Nutr J

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BackgroundSignificant associations between visceral fat and alterations in plasma fatty acids have been identified in overweight individuals. However, there are scant data regarding the relationships of the visceral fat area (VFA) with the plasma fatty acid profiles and desaturase activities following weight loss. We investigated the effect of weight loss with mild calorie restriction on the circulating fatty acid profiles and desaturase activities in nondiabetic overweight subjects with high VFA.MethodsEighty overweight subjects with high VFA (L4 VFA ≥100 cm2) were randomized into the 12-week mild-calorie-restriction (300 kcal/day) or control groups.ResultsComparison of the percent of body weight changes between groups revealed that the weight-loss group had greater reductions in body weight. The VFA decreased by 17.7 cm2 from baseline in the weight-loss group (P < 0.001). At follow-up, the weight-loss group showed greater reductions in serum triglycerides, insulin, and HOMA-IR than the control group. Significantly greater reductions in total saturated fatty acids, palmitic acid, stearic acid, total monounsaturated fatty acids, palmitoleic acid, oleic acid, eicosadienoic acid, and dihomo-γ-linolenic acid levels were detected in the weight-loss group compared with the control group after adjusting for baseline values. Following weight loss, C16 Δ9-desaturase activity was significantly decreased and Δ5-desaturase activity was significantly increased, and the changes were greater in the weight-loss group than in the control group.ConclusionsThe results suggest that mild weight loss improves abdominal obesity, overall fatty acid profiles, and desaturase activities; therefore, mild calorie restriction has potential health benefits related to obesity-related diseases in overweight subjects with high VFA.Trial registrationNCT02992639. Retrospectively registered 11 December 2016.

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Nutrition Assessment and Interventions for the Prevention and Treatment of Malnutrition in Older Adults: An Evidence Analysis Center Scoping Review

Moloney

Jarrett

2021

Journal of the Academy of Nutrition and Dietetics

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Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Cited by 5 publications

References 19 publications

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

Effect of weight loss on circulating fatty acid profiles in overweight subjects with high visceral fat area: a 12-week randomized controlled trial

Nutrition Assessment and Interventions for the Prevention and Treatment of Malnutrition in Older Adults: An Evidence Analysis Center Scoping Review

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