Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome

Gomes, Moisés Felipe Pereira; Moura, Elizabeth de Orleans Carvalho de; Cardoso, Naiara Magalhães; Silva, Graziele Aparecida da; Santos, Ana Carolina Cardoso dos; Souza, Fernanda Samantha de; Estadella, Débora; Lambertucci, Rafael Herling; Lago, João Henrique G.; Medeiros, Alessandra

doi:10.1038/s41598-023-28072-7

Cited by 3 publications

(2 citation statements)

References 69 publications

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Section: Resultsmentioning

confidence: 99%

“…Okra can function as a dietary therapy for hyperglycemia, especially in terms of maintaining a relatively ideal body weight (Erfani Majd et al, 2018;Gomes et al, 2023). Okra can be consumed fresh, processed by boiling, or fried, dried, but not made into flour (Adelakun & Oyelade, 2011;Gomes et al, 2023;Lea, 2013;Nnamezie et al, 2021;Ofori et al, 2020). This is based on the results of research by Astati and Kasmawati (2017) which showed that there was no effect of giving okra flour on body weight in diabetic Wistar rats between the control group and the treatment group.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Abelmoschus Esculentus Infused Water on Blood Glucose Levels of Rattus Norvegicus in Hyperglycemia Conditions

Zaenab

2024

J. Prisma. Sains

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Efforts to find alternative medicines or herbal-based interventions for diabetes sufferers are very necessary. The aimed of this study was to find out whether the use of okra fruit infusion (Abelmoschus esculentus) with different administration frequencies can reduce the blood sugar levels of hyperglycemic white rats (Rattus norvegicus), and to find out what frequency of giving okra fruit infusion can reduce blood sugar levels. white rat (Rattus norvegicus) tallest. This type of research is true experimental, consisting of 5 treatment groups, (P0-, P0+, P1, P2, and P3), namely negative control, positive control, giving 6 ml of okra fruit infusion water/day given once, giving infused water 6 ml of okra fruit/day was given 2 times a day and 6 ml of okra fruit infusion water was given 3 times a day. Each group consists of 5 repetitions. The research was carried out at the Chemistry Laboratory, Muhammadiyah University of Malang. The data collection method was by measuring the blood glucose levels of white mice that had been treated, then analyzing them using SPSS. Based on the results of data analysis and discussion, it can be concluded that there is an effect of the frequency of administration of okra fruit infusion on reducing blood sugar levels in white rats (hyperglycemia. Treatment P3 is a group of hyperglycemic rats that were given okra fruit infusion water at a dose of 6 ml/head/day, given once a day in the morning and P2, namely the group of hyperglycemic mice that were given okra fruit-infused water at a dose of 6 ml/head/day, given 2x a day in the morning and evening, is the best treatment because it has the same notation as P0 (negative control) or the group of mice that not given water infused with okra fruit and not given alloxan. Giving an infusion of okra fruit at a dose of 6 ml/head given once in the morning or twice (morning and evening) has an effect on reducing the blood sugar levels of hyperglycemic white mice. Okra can be consumed fresh, processed by boiling, or frying, dry, but not made into flour.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effects of Abelmoschus Esculentus Infused Water on Blood Glucose Levels of Rattus Norvegicus in Hyperglycemia Conditions

Zaenab

2024

J. Prisma. Sains

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Measurement of blood pressure in rats: Invasive or noninvasive methods?

Kapsdorferová,

Grešová,

Švorc

2024

Physiological Reports

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Experiments should always be based on control values. This assumption fully applies to cardiovascular parameters, such as heart rate (HR) and blood pressure (BP), which are highly sensitive to various external and internal stimuli and can already be significantly altered when an experiment begins. Therefore, it is necessary to determine which values are defined as a starting point (i.e., control and baseline) or compare them with valid reference values if the goal is to evaluate the changes after experimental intervention. A generally accepted principle is a reciprocal relationship between BP and HR, in which one parameter affects the other and vice versa. BP can be measured using two methods—noninvasively (tail‐cuff) and invasively (telemetry, direct measurements of BP after introducing the sensor directly into the artery), and HR directly or by extrapolation from BP recordings. This study does not aim to evaluate the results of individual studies, but to review whether there are differences in control (baseline) BP values in normotensive and hypertensive male rats using invasive versus noninvasive methods, and to investigate whether there is a causal relationship between BP and HR in in vivo experiments with male rats.

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The cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials

Bahari,

Shahraki Jazinaki,

Rahnama

et al. 2024

Front. Nutr.

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BackgroundThis systematic review and meta-analysis examine the effects of okra consumption on cardiometabolic risk factors in individuals with prediabetes and diabetes. Okra is a widely consumed vegetable with potential health benefits, and understanding its impact on metabolic parameters in these populations is important.MethodsA comprehensive search of the literature was conducted up to May 2024 in PubMed/Medline, Scopus, and Web of Science to find relevant randomized clinical trials (RCTs) by using following keyword: (“okra” OR “okras” OR “abelmoschus esculentus”) AND (“intervention” OR “controlled trial” OR “randomized” OR “randomized” OR “randomly” OR “clinical trial” OR “trial” OR “randomized controlled trial” OR “randomized clinical trial” OR “RCT” OR “blinded” OR “placebo” OR “Cross-Over” OR “parallel”). The selected trials were subjected to heterogeneity tests using the I2 statistic. Random effects models were examined based on the heterogeneity tests, and the pooled data were calculated as weighted mean differences (WMD) with a 95% confidence interval (CI). In this meta-analysis, all the analyses were performed by using the STATA version 17 software.ResultsOf the 1,339 papers, nine eligible RCTs were included in the present meta-analysis. Our findings indicated that okra consumption significantly reduced total cholesterol (TC) levels (WMD: −14.40 mg/dL; (95% CI: −20.94 to −7.86); p < 0.001), low-density lipoprotein (LDL) (WMD: −7.90 mg/dL; (95% CI: −13.30 to −2.48); p = 0.004), fasting blood glucose (FBG) (WMD: −39.58 mg/dL; (95% CI: −61.60 to −17.56); p < 0.001), and hemoglobin A1C (HbA1c) (WMD: −0.46 mg/dL; (95% CI: −0.79 to −0.13); p = 0.005). Overall effect size showed that okra intake failed to change triglycerides (TG), high-density lipoprotein (HDL), Insulin, homeostatic model assessment for insulin resistance (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight, and body Mass Index (BMI) significantly.ConclusionOkra decreased TC, LDL, FBG, and HbA1c levels in the intervention compared to the control group. A dose ≤3,000 mg/day caused a significant decrease in TG, TC, LDL, HbA1c, and a significant increase in HDL. More study is needed to determine the optimum dose and duration of intervention.

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Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome

Cited by 3 publications

References 69 publications

Effects of Abelmoschus Esculentus Infused Water on Blood Glucose Levels of Rattus Norvegicus in Hyperglycemia Conditions

Effects of Abelmoschus Esculentus Infused Water on Blood Glucose Levels of Rattus Norvegicus in Hyperglycemia Conditions

Measurement of blood pressure in rats: Invasive or noninvasive methods?

The cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials

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