Supplementation with omega-3 acids after myocardial infarction and modification of inflammatory markers in light of the patients’ diet: a preliminary study

Abstract

A b s t r a c tBackground: Neuroendocrine activation, activation of proinflammatory cytokines and platelets, and endothelial dysfunction play a significant role in the development of heart failure (HF). Aim:The aim of the work was to assess the effect of supplementation with EPA and DHA in a daily dose of 1 g on selected inflammatory markers and platelet activation in patients with HF after recent myocardial infarction in light of their diet. Methods:This preliminary study was a randomised, double-blind trial involving 30 patients with post-infarction HF. One group received a product containing 1 g of omega-3 acids, while the other received placebo, i.e. corn oil 1 g daily for 12 weeks. At baseline and at week 12, venous blood was obtained in the fasted state in order to determine the following parameters: NT-proBNP, fibrinogen, INR, creatinine clearance, serum lipid profile, hsCRP, troponin, glucose, transaminases, GGTP, MCP-1, pentraxin 3, and CD-40. To evaluate the patient's diet and dietary intake of omega-3 acids, a 24-h dietary interview and the Block's Food Frequency Questionnaire (FFQ) were applied.Results: Supplementation of omega-3 acids in a dose of 1 g per day had no effect on lipid or inflammatory parameters, with the exception of pentraxin 3. In both groups, after three months of supplementation, overall consumption of energy and saturated fatty acids was significantly higher (p < 0.05). Conclusions:Potential benefits associated with supplementation were nullified by a highly atherogenic diet. Apparently, supplementation of omega-3 acids without simultaneous dietary education and nutrition control does not bring the expected effect. Further research involving a larger group of patients is needed to better understand the relationship between patient's diet and the effectiveness of omega-3 supplementation.

Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux

“…EPA has been widely tested for its benefits as a dietary supplement or as neoadjuvant therapy in cancer because of its anti-inflammatory qualities and safe toxicity profile 21–23 . However, it has never been considered a mainstream approach in cancer treatment.…”

Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease

“…Long-chain polyunsaturated fatty acids (PUFAs) and their derivatives can modulate many metabolic and inflammatory pathways in diabetic and nondiabetic subjects [ 15 – 19 ]. Epidemiological evidence has indicated that populations with high fish consumption had less risk of diabetes and ASCVD [ 20 ].…”

Intestinal microbiota in the pathogenesis of chronic heart failure

“…The importance of dietary fiber deficiency in patients with CHF and the anti-inflammatory properties of prebiotic doses of lactulose have been observed. 46,47 One of the promising research directions is the probiotics influence on the metabolic pathways through which the gut microbes can effect on the host organism. For example, the TMAO production decrease can be achieved by blocking the enzyme choline-TMA-lyase, which converts choline to TMA.…”