Supplementation with Phaseolus vulgaris Leaves Improves Metabolic Alterations Induced by High-Fat/Fructose Diet in Rats Under Time-Restricted Feeding

Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease

“…Bean leaves are a source of bioactive compounds like iron, protein, insoluble fiber, and polyphenols. Bioactive compounds of plant-based foods have been shown to play a role in the prevention of metabolic disorders related to high-fat/high-fructose diets [ 7 , 8 ]. The 10% of bean leaves supplementation that has shown a protective effect against lipotoxicity in fatty liver disease (12.6 g/kg body weight), extrapolated to humans the dose should be 2 g/kg of body weight [ 42 ].…”

“…In a previous study, where bean leaves supplementation with 7-h daytime RFP was evaluated, fasting glucose levels and insulin resistance (HOMA-IR) were lower after 8 weeks of treatment [ 8 ]. Dietary fiber and phenolic compounds present in bean leaves had shown an increase in SCFA production on cecal content [ 7 ].…”

“…Even when previous studies with bean leaves supplementation in high-fat/high-fructose diets had not shown decreases in circulating lipid levels [ 7 , 8 , 54 ], bean leaves supplementation with RFP downregulated Scd1 (stearyl-coenzyme A desaturase1) expression in liver [ 8 ], leading to triglycerides exportation, keeping high levels of VLDL-c and triglycerides in circulation [ 54 ]. As with other plant-based diet interventions, bean leaf intake should be evaluated together with physical activity and changes in lifestyle [ 55 ].…”

“…Plant extracts, probiotics, and prebiotics had been useful in NAFLD treatment by reducing inflammation and increasing the antioxidant defense system, particularly GSH levels [ 68 ]; and bean leaves had shown an important content of polyphenols and dietary fiber besides preventing obesity-related comorbidities [ 6 , 7 , 8 ]. This is the first study that evaluates the effect of bean leaves on NAFLD.…”

“…In this regard, the effect of bean leaves supplementation in the high-fat/high-fructose feeding model was evaluated. After 8 weeks, under a 7-h daytime-restricted-feeding protocol (RFP), 10% of bean leaves supplementation improved insulin sensitivity, and diminished hepatic fat accumulation and hyperlipidemia [ 8 ]. Additionally, ad libitum bean leaves supplementation (10%) for 6 weeks without RPF prevented obesity and impairments in glucose metabolism, possibly related to an increase of 54% in SCFA (short-chain fatty acids) production [ 7 ].…”