Supplementation with Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults with Abdominal Obesity: A Randomized, Placebo-Controlled Crossover Trial

Abstract

Acute supplementation with Res/Cur has no impact on the postprandial inflammation response to a high-fat meal in abdominally obese older adults. Further studies are warranted to examine how resveratrol and curcumin may alter the vascular response to a high-fat meal. This trial was registered at clinicaltrials.gov as NCT01964846.

Effects of Acute Dietary Polyphenols and Post-Meal Physical Activity on Postprandial Metabolism in Adults with Features of the Metabolic Syndrome

“…In contrast to the 60 g grape powder supplementation by Bardagjy et al [53], resveratrol and curcumin supplementation by Vors et al caused a 4643% reduction in 6-h sVCAM-1 iAUC compared to the control phase (p = 0.01). The 6-h IL-6, interleukin 8, MCP-1, C-reactive protein (CRP), sICAM-1, or soluble endothelial selectin (sE-selectin) iAUC did not differ (p > 0.05) [54].…”

“…Resveratrol and curcumin are flavonoids, a class of bioactive dietary molecules shown to benefit metabolic processes [76][77][78]. However, the supplementation of two capsules containing 200 mg resveratrol and 100 mg curcumin did not affect 6-h glucose or insulin in a sample of older adults [54]. A majority of these participants were overweight according to BMI (≥25.0 and <30.0 kg/m 2 ) and obese according to waist circumference but were normoglycemic.…”

“…In another clinical trial, Edirisinghe et al reported that 300 mg grape seed extract reduced 6-h glucose area under the curve (AUC) by 3.5% (p < 0.05) but did not affect 6-h insulin, TG, or total cholesterol (TC) AUC (p > 0.05) compared to the control phase [58]. Vors et al administered two capsules (total of 200 mg resveratrol (found in grapes) and 100 mg curcumin (found in turmeric)) to adults and did not find significant differences in 6-h glucose, insulin, or TG iAUC compared to the control phase (p > 0.05) [54]. Mean ± standard deviation (SD); impaired fasting glucose; EVOO: extra virgin olive oil; kcal: kilocalories; CHO: carbohydrate; PRO: protein; NR: not reported; ApoB48: apolipoprotein B48; PBO: placebo treatment; LPS: lipopolysaccharides; h: hour; OxLDL: oxidized low-density lipoprotein cholesterol; sNox2-dp: soluble Nox2-derived peptide; United States of America; MetS: metabolic syndrome; GP: whole grape powder; NS: non-significant difference between treatments; h: hour; iAUC: incremental area under the curve; TG: triglycerides; ET-1: endothelin-1; PBO: placebo treatment; IL-6: interleukin-6; MCP-1: monocyte chemoattractant protein-1; OxLDL: oxidized low-density lipoprotein cholesterol; PAI-1: plasminogen activator inhibitor-1; RBP4: retinol-binding protein 4; sICAM-1: soluble intercellular adhesion molecule-1; sVCAM-1: soluble vascular cell adhesion molecule-1; TNF: tumor necrosis factor; Res: resveratrol; Cur: curcumin; g: grams; IL-8: interleukin-8; CRP: C-reactive protein; sE-selectin: soluble endothelial selectin; mL: milliliters; BTPP: black tea polymerized polyphenols; BB: black beans; AF; added fiber; NF: no fiber; IFG: impaired fasting glucose; FDS: freeze-dried strawberries; I:G ratio: insulin-to-glucose ratio; ORAC: oxygen radical absorbance capacity; FM: fiber-matched; AM: antioxidant-matched; GSE: grape seed extract; AUC: area under the curve; BC: blackcurrant; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; IL-1β: interleukin-1β; PON: paraoxonase; hs-CRP: high-sensitivity C-reactive protein.…”

“…The distribution of the features of MetS among participants in the clinical trials was as follows: eleven clinical trials (twelve reports) included participants who met the MetS criterion for abdominal obesity (body mass index (BMI) ≥ 30.0 kilograms [kg]/m 2 , waist circumference > 40 in/102 centimeters (cm) for males and >35 in/88 cm for females) [52][53][54][55][56][57][58][59][60][61][62][63]; twelve clinical trials (thirteen reports) included participants who either met the MetS criterion for fasting dysglycemia or had IGT (blood glucose ≥ 140 mg/dL 2 h after oral glucose tolerance test (OGTT)) [52,[55][56][57][58][59][60][61][62][64][65][66][67]; five clinical trials (six reports) included participants who met the MetS criterion for fasting dyslipidemia [58][59][60]63,64]; and five clinical trials (six reports) included participants who met the MetS criterion for elevated blood pressure [53,55,57,58,60,61].…”

“…Nine clinical trials evaluated the effects of supplementing a dietary challenge with dietary polyphenols from oils, fruits, teas, and legumes on postprandial metabolism in adults with features of MetS ( Table 1). The dietary polyphenols were obtained from extra virgin olive oil [52], grapes [53,58], resveratrol and curcumin powder [54], strawberries [56,68,69], blackcurrant [59], black tea [64], and black beans (one clinical trial with two reports) [55,57]. In seven of the clinical trials, the dietary polyphenols were consumed with a dietary challenge [52][53][54][55][56][57][58]68,69].…”