Supplementation with vitamin D and insulin homeostasis in healthy overweight and obese adults: A randomized clinical trial

Ebadi, Seyed Alireza; Sharifi, Laleh; Rashidi, Elaheh; Khalili, Shayesteh; Sadeghi, Sajjad; Afzali, Nikta; Shiri, Sakineh Moghadam

doi:10.1016/j.orcp.2021.03.004

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…In the glycemia aspects, 5 trails showed that there was no statistically significant difference in HOMA-IR or any the other outcomes about FPG, FI or QUICKI (Wongwiwatthananukit et al, 2013;Raja-Khan et al, 2014;Salekzamani et al, 2016;Corcoy et al, 2020;Cojic et al, 2021). However, 2 trails reported a greater decrease in FPG, FI and HOMA-IR in the VDS group compared with the placebo group (Maktabi et al, 2017;Ebadi et al, 2021). Regarding biomarkers of inflammation and oxidative stress, Imanparast, F. et al reported a greater decrease in MDA and hs-CRP after the treatment of VDS (Imanparast et al, 2020), which was not found in the study conducted by Cojic et al (Cojic et al, 2021).…”

Section: Results Of the Included Rctsmentioning

confidence: 99%

“…There were 32 full text articles left, from which we excluded 19 trials based on 1) date expressed as median (Interquartile range, IQR) ( n = 4), 2) studies with a follow up less than 4 weeks or longer than 28 weeks ( n = 3), 3) not on VDS ( n = 3),4) not on adults ( n = 3), 5) subjects are healthy people or suffering from other diseases ( n = 5), 6) full text not retrieved ( n = 1). Ultimately, a total of 13 RCT articles ( Wongwiwatthananukit et al, 2013 ; Raja-Khan et al, 2014 ; Mahmood et al, 2016 ; Salekzamani et al, 2016 ; Maktabi et al, 2017 ; Farag et al, 2019 ; Makariou et al, 2019 ; Shidfar et al, 2019 ; Corcoy et al, 2020 ; Imanparast et al, 2020 ; Cojic et al, 2021 ; Ebadi et al, 2021 ; Pragya et al, 2021 ) were included in the final systematic review and meta-analysis, for a total of 1,076 study subjects.…”

Section: Resultsmentioning

confidence: 99%

“…Blinding of participants was not clear in 4 trails ( Farag et al, 2019 ; Corcoy et al, 2020 ; Imanparast et al, 2020 ; Cojic et al, 2021 ), since they did not mention the randomization method. All trials had adequate blinding of outcome assessment, except 4 trails ( Mahmood et al, 2016 ; Makariou et al, 2019 ; Corcoy et al, 2020 ; Ebadi et al, 2021 ) were unclear. Only 2 trials reported incomplete outcome date ( Shidfar et al, 2019 ; Imanparast et al, 2020 ), the rest of studies were in low risk of attrition bias.…”

Section: Resultsmentioning

confidence: 99%

“…All the included RCTs reported significant increase in serum 25(OH)D levels in the intervention groups at endline. For anthropometric parameters and blood pressure, BMI was analyzed in 9 trails ( Raja-Khan et al, 2014 ; Mahmood et al, 2016 ; Salekzamani et al, 2016 ; Makariou et al, 2019 ; Shidfar et al, 2019 ; Imanparast et al, 2020 ; Cojic et al, 2021 ; Ebadi et al, 2021 ; Pragya et al, 2021 ). Eight of them showed no difference in BMI after the intervention compared to baseline values in the experimental group.…”

Section: Results Of the Included Rctsmentioning

confidence: 99%

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The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Zhang

et al. 2022

Front. Pharmacol.

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Background: Studies have shown the association of vitamin D status with the development of metabolic syndrome (MetS), which has attracted an extensive research interest with inconsistent results. Therefore, we hypothesized that vitamin D supplementation (VDS) will benefit adults with MetS.Aims: To test our hypothesis, we performed a meta-analysis to evaluate the effect of VDS on MetS in adults using relevant biomarkers such as anthropometric parameters, blood pressure, blood lipid profile, glycemia, oxidative stress and vitamin D toxicity (VDT).Methods: Randomized controlled trials published in PubMed, Web of Science, embase and the Cochrane Library between 2012 and 2022 on the effect of VDS on MetS in adults were searched. The language was limited to English. A meta-analysis performed using RevMan 5.4 and Stata 14.0 software, sensitivity analysis, and evaluation of the risk of bias and general quality of the resulting evidence were conducted.Results: Eventually, 13 articles were included in this meta-analysis. Overall, VDS significantly increased the endline serum 25-hydroxyvitamin D levels as compared to the control [MD:17.41, 95% CI (14.09, 20.73), p < 0.00001]. VDS did not affect waist circumference, body mass index, body fat percentage and VDT biomarkers, but decreased waist-to-hip ratio and blood pressure (p < 0.01). VDS significantly decreased fasting plasma glucose (FPG) [MD: 3.78; 95% CI (−6.52, −1.03), p = 0.007], but did not affect the levels of blood high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Pooled estimate of nine papers indicated a significant reduction of fasting insulin (FI) (p = 0.006), and homeostasis model assessment of insulin resistance (p = 0.0001). The quantitative insulin check index levels were moderately increased (p = 0.007) without any impact on the glycosylated hemoglobin type A1C (HbA1c). For the oxidative stress parameters, VDS significantly lowered the levels of malondialdehyde and hypersensitive C-reactive protein (p < 0.05).Conclusion: Results of this meta-analysis demonstrate that VDS only reduces insulin resistance and hypertension but not the blood lipid profile and HbA1c. It appears that the evidence for the benefit of VDS in adults with MetS is inconclusive. Further clinical studies are still needed.

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Section: Results Of the Included Rctsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Results Of the Included Rctsmentioning

confidence: 99%

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The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Zhang

et al. 2022

Front. Pharmacol.

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“…Chronic inflammatory reaction increases IR, disrupts the function of pancreatic β cells and insulin secretion. Vitamin D deficiency can also worsen the function of β cells in the pancreas [ 57 , 58 , 59 , 60 ].…”

Section: Pregnancy As a Window For The Development Of Metabolic Diseasesmentioning

confidence: 99%

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

Obuchowska

GORCZYCA

Standyło

et al. 2022

IJMS

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Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a “window” to the mother’s future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother’s future.

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The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials

Yu,

Song,

et al. 2025

Prostaglandins & Other Lipid Mediators

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Supplementation with vitamin D and insulin homeostasis in healthy overweight and obese adults: A randomized clinical trial

Cited by 7 publications

References 20 publications

The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials

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