Supplementation With Vitamins C and E Improves Arterial Stiffness and Endothelial Function in Essential Hypertensive Patients

Plantinga, Yvonne; Ghiadoni, Lorenzo; Magagna, Armando; Giannarelli, Chiara; Franzoni, Ferdinando; Taddei, Stefano; Salvetti, Antonio

doi:10.1016/j.amjhyper.2006.09.021

Cited by 198 publications

(144 citation statements)

References 36 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…PWV was calculated as the ratio of the surface distance between the two recording sites and wave-transit time. Variation coefficients for repeated measurement of AIx and PWV in our laboratory were 14% and 13%, respectively [22].…”

Section: Methodsmentioning

confidence: 99%

Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes

et al. 2011

View full text Add to dashboard Cite

Aim/hypothesis Renal resistive index is a useful measure for quantifying alterations in renal blood flow. In the present study we evaluated resistive index at baseline and after vasodilation induced by nitroglycerine in normoalbuminuric patients with type 2 diabetes or essential hypertension, relating the values to indices of systemic vascular dysfunction. Methods Newly diagnosed treatment-naïve type 2 diabetic (n=32) and hypertensive patients (n=49) were compared with 27 age-and sex-matched healthy controls. Renal resistive index was obtained by duplex ultrasound at baseline and after 25 μg sublingual nitroglycerine. Endothelium-dependent (flow-mediated dilation) and -independent (response to nitroglycerine) vasodilation in the brachial artery was assessed by computerised edge detection system. Carotid-femoral pulse-wave velocity and augmentation index were assessed by applanation tonometry. Nitrotyrosine levels, an index of oxidative stress, were also measured. Results Resistive index was higher in diabetic than in hypertensive patients and controls (p < 0.001), while changes in resistive index induced by nitroglycerine were lower in hypertensive patients compared with controls (p< 0.01), and were further reduced in type 2 diabetic patients. Hypertensive and diabetic patients showed significantly increased arterial stiffness, nitrotyrosine levels and reduced endothelial function than controls (p<0.05). Changes in resistive index induced by nitroglycerine were independently related to serum glucose, reactive hyperaemia and aortic pulse-wave velocity in the overall population. Conclusions/interpretation These results support the dynamic evaluation of renal resistive index as an early detector of renal vascular alterations in the presence of type 2 diabetes and hypertension, even before the onset of microalbuminuria.

show abstract

Section: Methodsmentioning

confidence: 99%

Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes

et al. 2011

View full text Add to dashboard Cite

show abstract

“…This was thought to reflect the decreased PFLA and wall thickness in the distal thoracic aorta. Plantinga et al 33 showed that short-term supplementation of the diet with antioxidative vitamins C and E in patients with essential hypertension ameliorated endothelial function and lowered PWV. However, it is difficult to illustrate that the decrease in E p is only due to the antiatherogenic effect of serotonin derivatives, because there are some paradoxical observations in which a smaller E p was shown in the aortic wall with early atherosclerotic lesions when compared with the lesion-free normal wall.…”

Section: Inhibitory Effect Of Cs and Fs On Atherosclerosismentioning

confidence: 99%

“…31,38,39 Oxidative stress reduces the bioavailability of nitric oxide, which could lead to suppressed endothelium-derived vasodilation. 38,39 It has been reported that supplementation of antioxidative vitamins improved the endothelium-derived vasodilating function in essential hypertensive 33 and hypercholesterolemic 40 patients. Piga et al 41 recently demonstrated a protective effect of CS and FS against high glucose-induced oxidative damage in cultured human aortic endothelial cells.…”

Section: Inhibitory Effect Of Cs and Fs On Atherosclerosismentioning

confidence: 99%

Safflower seed polyphenols (N-(p-coumaroyl)serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits

et al. 2009

View full text Add to dashboard Cite

Pulse wave velocity (PWV) has been used clinically as a direct measure of arterial stiffness. We investigated the inhibitory effects of defatted safflower seed extract (SSE) and serotonin derivatives (N-(p-coumaroyl)serotonin, N-feruloylserotonin; CS+FS), which are the active components in SSE, on hypercholesterolemia and atherosclerosis, using PWV in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. SSE and CS+FS were supplemented with a commercial diet containing 0.5% cholesterol for 8 weeks in male KHC rabbits, aged 2 months. Pulse waves were recorded at different aortic positions using two catheters with micromanometers under pentobarbital anesthesia. The atherosclerotic lesioned area in the aorta was significantly reduced in the SSE and CS+FS groups, without significant changes in serum cholesterol and triglyceride levels among the three groups after supplementation. Local PWV (LPWV) in the middle thoracic and distal abdominal aortas was significantly smaller in the SSE and CS+FS groups than in the control group. PWV in the entire aorta was also significantly lower in the SSE and CS+FS groups, compared with that in the control group. Pressure-strain elastic modulus, an index of wall distensibility, was significantly lower in the middle thoracic and middle abdominal aortas in the SSE and CS+FS groups than in the control group. Wall thickness was also significantly smaller in the middle thoracic aorta in the SSE and CS+FS groups compared with that in the control group. Serotonin derivatives inhibited the progress of atherosclerosis and ameliorated wall distensibility, which contributed, in part, to the lowering of LPWV. Serotonin derivatives may be beneficial in improving vascular distensibility and in reducing cardiovascular risk.

show abstract

“…En un estudio prospectivo, 3258 varones de 60-79 años (sin diagnóstico de infarto de miocardio, ictus o diabetes), se observó que los niveles plasmáticos de vitamina C se relacionaron inversamente con los niveles de PCR-us y del tPA (116). Otro estudio, aleatorizado, doble ciego y controlado con placebo, se demostró que el consumo de vitamina C y E favorece la vasodilatación dependiente del endotelio en pacientes hipertensos esenciales no tratados (117). En la tabla 2 se resume el diseño y resultados de varios estudios en que se analizó la actividad de vitamina C y E en la función endotelial.…”

Section: Acción De áCidos Grasos Insaturadosunclassified

El Consumo De Frutas Y Hortalizas Ayuda a Prevenir El Daño Endotelial

Palomo

Moore‐Carrasco

et al. 2011

Rev. chil. nutr.

View full text Add to dashboard Cite

INTRODUCCIÓNLa células endoteliales, entre otras funciones, regulan el tono y permeabilidad vascular, adhesión leucocitaria y la hemostasia (1). Dentro de los mecanismos que regulan las funciones del endotelio, la producción de óxido nítrico (NO) es de central importancia. ABSTRACT The endothelium helps to maintain the normal structure and homeostasis of the vasculature. However, chronic exposure to cardiovascular (CV) risk factors causes endothelial dysfunction, a phenomenon that is characterized by inflammation, reduced bioavailability of nitric oxide (NO) and a prothrombotic state. Epidemiological studies have shown that regular consumption of fruits and vegetables reduces CV risk, which has caused interest in knowing the bioactive compounds and the mechanisms involved. Among the components that protect the endothelium are antioxidants (vitamin C, vitamin E and polyphenols) and polyunsaturated fatty acids. Vitamin C and E promote vasodilatation protecting NO by blocking the reactive oxygen species (ROS). Polyphenols improve endothelial function primarily by increasing levels of NO, and inhibition of angiogenesis and platelet activation. Diets rich in polyunsaturated fatty acids have shown beneficial effects by reducing the gene expression of cyclooxygenase-2 and the expression of cell adhesion molecules. This review mainly highlights the current understanding of endothelial dysfunction and the protective effect of endothelial cells by bioactive components of fruits and vegetables.

show abstract

Supplementation With Vitamins C and E Improves Arterial Stiffness and Endothelial Function in Essential Hypertensive Patients

Abstract: Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients. This effect is associated with changes in plasma markers of oxidative stress.

Cited by 198 publications

References 36 publications

Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes

Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes

Safflower seed polyphenols (N-(p-coumaroyl)serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits

El Consumo De Frutas Y Hortalizas Ayuda a Prevenir El Daño Endotelial

Contact Info

Product

Resources

About