Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Stewart-Knox, Barbara J.; Rae, Gordon; Simpson, E.; McConville, Christopher F; O’Connor, Jacqueline M.; Polito, Angela; Andriollo-Sanchez, M; Coudray, Charles; Strain, JJ

doi:10.1017/s1368980010002764

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…We used self-report and well-established clinical hormone assessment to determine menopausal status. The use of well-established and validated repeated measures of mood is also a strong support for the study 20 and has been validated in previous dietary intervention trials on healthy older adults 39,47 .…”

Section: Discussionmentioning

confidence: 94%

“…A total of 101 postmenopausal women completed the study. As the original power calculation was based on cognition, a retrospective one was carried out to confirm the sample size required for mood, based on a small effect size of .2, found in previous study on mood and dietary intervention 39 , with a power of 0.8 and a 0.05 level of significance, 66 participants were required. An overview of the age range across the groups and educational level in each group is given in Table 1.…”

Section: Sample Descriptionmentioning

confidence: 99%

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The effect of a randomized 12-week soy drink intervention on everyday mood in postmenopausal women

et al. 2019

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Objective: Dietary soy may improve menopausal symptoms, and subsequently mediate mood. This novel study examines various does of dietary soy drink on everyday mood stability and variability in postmenopausal women. Methods: Community dwelling women (n=101), within 7 years post menopause consumed daily either a low (10mg, n=35), medium (35mg, n=37) or high (60mg, n=29) dose of isoflavones, for twelve weeks. Menopausal symptoms and repeated measures of everyday Mood (Positive (PA) and Negative (NA) affect) (assessed at four time points per day for four consecutive days, using PANAS) were completed at baseline and follow up. Results: The dietary soy intervention had no effect on everyday mood stability (for PA (F(2,70) = .95, p = .390) and NA (F(2,70) = 0.72, p = .489) or variability (for PA (F(2,70) = .21, p = .807) and for NA (F(2,70) = .15, p=.864) or on menopausal symptoms (for vasomotor (F (2,89) = 2.83, p = .064), psychological (F (2,88) = 0.63, p = .535), somatic (F (2,89) = 0.32, p =.729) and total menopausal symptoms (F (2,86) = 0.79, p = .458)). There were between group differences with the medium dose reporting higher PA (low, mean: 24.2, SD: 6 and medium, mean: 29.7, SD: 6) and the low dose reporting higher NA (P = 0. 048) (Low, mean: 11.6, SD: 2 and high, mean: 10.6, SD: 1) in mood scores. Psychological (baseline M = 18 and follow up M = 16.5) and vasomotor (baseline M = 4.2 and follow up M = 3.6) scores declined from baseline to follow up for the overall sample. Conclusions: Soy isoflavones had no effect on mood at any of the doses tested. Future research should focus on the menopausal transition from peri to post menopause as there may be a window of vulnerability, with fluctuating hormones and increased symptoms which may affect mood.

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Section: Discussionmentioning

confidence: 94%

Section: Sample Descriptionmentioning

confidence: 99%

The effect of a randomized 12-week soy drink intervention on everyday mood in postmenopausal women

et al. 2019

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“…Zinc was measured via auto-analysis. After these steps, zinc supplements containing 30 mg of zinc (Nature Made nutritional supplements) (23) were administered to older adults in the intervention group for 10 weeks (24).…”

Section: Methodsmentioning

confidence: 99%

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

Afzali¹,

Mohandes²,

Goli³

et al. 2022

Acta fac medic Naissensis

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Introduction/Aim: The use of macronutrient and micronutrient foods is associated with the duration of sleep. This study aimed to determine the effect of zinc supplements on the sleep quality of older adults. Methods: The current parallel randomized clinical trial study was performed using a convenience sampling method. One hundred and fifty older adults who met the inclusion criteria were assigned to intervention and control group. The participants in the intervention group received a daily dose of 30 mg zinc supplementation pill for 70 days and the control group did not receive any supplement. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). Serum zinc level in both groups was measured through the auto-analysis method. The questionnaire was completed and the serum level of zinc was measured twice, before the intervention and 70 days after the intervention. Results: Both groups were homogeneous in terms of demographic variables, sleep quality, and serum zinc level before the intervention. Of all, 73.3% of older adults in the intervention group and 74.7% of older adults in the control group had poor sleep quality. Sleep quality in the intervention group, as compared with the control group, significantly improved after the intervention. Furthermore, serum zinc levels in older adults in the intervention group, as compared with the control group, significantly increased after the intervention. Conclusion: Based on the results of this study, it is recommended to utilize zinc supplementation as a new therapeutic approach for improving sleep quality in older adults.

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“…Five milliliters of blood were taken from each participant for measuring serum zinc level at baseline. Zinc supplements containing 30 mg zinc 25 were administered daily for 10 weeks to subjects in the intervention group. 26 Prior to the administration of a full dose of zinc supplement, in order to prevent possible side effects of the zinc, seven pills (equal to a total dose of 210 mg) were administered to the elderly in the intervention group.…”

Section: Interventionmentioning

confidence: 99%

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

Afzali

Goli

Moravveji

et al. 2021

Health Science Reports

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Background and Aims: Fatigue is one of the most common complaints of the elderly.This study was conducted to assess the effect of zinc supplements on fatigue among the elderly.Methods: This randomized clinical trial was conducted on 150 elderly aged ≥60 years who were recruited from the health centers (Kashan, Iran) with a convenience sampling method. Participants were allocated to intervention and control groups by block randomization. Participants in the intervention group received a daily dose of 30 mg of zinc supplement for 70 days; meanwhile, in the control group, no intervention was performed. The level of fatigue was measured by the multidimensional fatigue inventory before and after the intervention. Both groups were homogeneous in terms of demographic variables, fatigue, and serum zinc level before the intervention. The significance level was considered as 0.05 in all tests.Results: Zinc supplementation significantly reduced fatigue (mean difference: À10.41 vs 1.37, P < .001) and increased serum zinc level (mean difference: 14.22, vs À0.57, P < .001) compared to the control group. Conclusion:Consumption of zinc supplements for the elderly is recommended to overcome fatigue.

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Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Cited by 7 publications

References 55 publications

The effect of a randomized 12-week soy drink intervention on everyday mood in postmenopausal women

The effect of a randomized 12-week soy drink intervention on everyday mood in postmenopausal women

Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

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