Supplementing diet with Manitoba lingonberry juice reduces kidney ischemia‐reperfusion injury

Isaak, Cara K.; Wang, Pengqi; Prashar, Suvira; Karmin, O; Brown, Daniel C.; Debnath, Samir C.; Siow, Yaw L.

doi:10.1002/jsfa.8200

Cited by 13 publications

(10 citation statements)

References 53 publications

(61 reference statements)

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“…Lingonberry (Vaccinium vitis-idaea L.) is an evergreen dwarf shrub rich in anthocyanins, which has anti-inflammatory, anti-diabetic, and renal protection properties [64,65]. In another study, mice were fed with a high-fat diet (HFD) to induce chronic kidney injury for investigating the effects of lingonberry on CKD.…”

Section: Lingonberrymentioning

confidence: 99%

The Therapeutic Strategies for Uremic Toxins Control in Chronic Kidney Disease

Wei

et al. 2021

Toxins

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Uremic toxins (UTs) are mainly produced by protein metabolized by the intestinal microbiota and converted in the liver or by mitochondria or other enzymes. The accumulation of UTs can damage the intestinal barrier integrity and cause vascular damage and progressive kidney damage. Together, these factors lead to metabolic imbalances, which in turn increase oxidative stress and inflammation and then produce uremia that affects many organs and causes diseases including renal fibrosis, vascular disease, and renal osteodystrophy. This article is based on the theory of the intestinal–renal axis, from bench to bedside, and it discusses nonextracorporeal therapies for UTs, which are classified into three categories: medication, diet and supplement therapy, and complementary and alternative medicine (CAM) and other therapies. The effects of medications such as AST-120 and meclofenamate are described. Diet and supplement therapies include plant-based diet, very low-protein diet, probiotics, prebiotics, synbiotics, and nutraceuticals. The research status of Chinese herbal medicine is discussed for CAM and other therapies. This review can provide some treatment recommendations for the reduction of UTs in patients with chronic kidney disease.

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Section: Lingonberrymentioning

confidence: 99%

The Therapeutic Strategies for Uremic Toxins Control in Chronic Kidney Disease

Wei

et al. 2021

Toxins

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“…Lingonberry ( Vaccinium vitis‐idaea L.) is a perennial, evergreen dwarf shrub native to northern latitudes and is well known for its high content of anthocyanins and antioxidants compared with other commonly consumed berries (Bakowska‐Barczak et al ., ; Isaak et al ., ). It has been traditionally used in diets not only because it confers the appealing colour to the food, but also because it has been considered as a ‘good for health’ berry rich in vitamins C, A, E and polyphenols (Mane et al ., ; Bujor et al .,; Finnish Food Composition Database).…”

Section: Introductionmentioning

confidence: 97%

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Zhang

Zhou

Huangfu

et al. 2018

Int J of Food Sci Tech

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This study is aimed to evaluate the hypocholesterolaemic effect of anthocyanin extracts of lingonberry (LAE) in vitro and vivo studies. In vitro, LAE can effectively inhibit the micellisation of cholesterol with significant dose-effect relationship. In animal experiments, after 10-weeks of LAE administration, lower values of body mass, daily food intake, liver weight, visceral adipose content, TC level, LDL-C level, fasting blood glucose level and higher HDL-C level in serum, cholesterol content and total bile acid content in faeces are observed in HCD-induced hypercholesterolaemic mice compared with model group. These observations suggest that LAE could promote the metabolism of serum cholesterol in HCD-induced hypercholesterolaemic mice primarily via faecal excretion of cholesterol. Furthermore, LAE may reduce the inflammatory cell infiltration and attenuate steatosis and hepatocellular fat deposit in the liver. Our results indicate that LAE is a potential dietary supplement in cholesterol-lowering or for hypercholesterolaemic treatment. These findings may provide important basis for further optimisation of dietary anthocyanins utilisation.

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“…Certain dietary restrictions are recommended to control the intake of protein, sugar, salt, and fiber content (18). In our previous study, we reported that supplementation of diet with lingonberry juice could protect rats against ischemia-reperfusion-induced acute kidney injury (19). Lingonberry (Vaccinium vitis-idaea L.) is an evergreen dwarf shrub native to North America and Eurasia throughout the Northern Hemisphere (20).…”

Section: Introductionmentioning

confidence: 99%

“…Among these, C-3-Glu is known to improve the redox status, energy, and glucose metabolism in rat kidneys (24). Furthermore, recent studies have revealed that lingonberry exhibits antidiabetic and renal protective properties (19,25). However, its role in CKD has not been identified.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Inflammatory Cytokine Expression Prevents High-Fat Diet-Induced Kidney Injury: Role of Lingonberry Supplementation

et al. 2020

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Chronic low-grade inflammation is a major stimulus for progression of chronic kidney disease (CKD) in individuals consuming high-fat diet. Currently, there are limited treatment options for CKD other than controlling the progression rate and its associated complications. Lingonberry (Vaccinium vitis-idaea L.) is rich in anthocyanins with demonstrated anti-inflammatory effect. In the current study, we investigated the potential renal protective effect of lingonberry and its anthocyanin (cyanidin-3-glucoside) in high-fat diet fed obese mice and in human proximal tubular cells. Prolonged consumption of high-fat diets is strongly associated with obesity, abnormal lipid and glucose metabolism. Mice (C57BL/6J) fed a high-fat diet (62% kcal fat) for 12 weeks developed renal injury as indicated by an elevation of blood urea nitrogen (BUN) level as well as an increase in renal kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and renin expression. Those mice displayed an activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and increased expression of inflammatory cytokines-monocyte chemoattractant-1 (MCP-1), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) in the kidneys. Mice fed a high-fat diet also had a significant elevation of inflammatory cytokine levels in the plasma. Dietary supplementation of lingonberry for 12 weeks not only attenuated high-fat diet-induced renal inflammatory response but also reduced kidney injury. Such a treatment improved plasma lipid and glucose profiles, reduced plasma inflammatory cytokine levels but did not affect body weight gain induced by high-fat diet feeding. Lingonberry extract or its active component cyanidin-3-glucoside effectively inhibited palmitic acid-induced NF-κB activation and inflammatory cytokine expression in proximal tubular cells. These results suggest that lingonberry supplementation can reduce inflammatory response and prevent chronic kidney injury. Such a renal protective effect by lingonberry and its active component may be mediated, in part, through NF-κB signaling pathway.

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Supplementing diet with Manitoba lingonberry juice reduces kidney ischemia‐reperfusion injury

Cited by 13 publications

References 53 publications

The Therapeutic Strategies for Uremic Toxins Control in Chronic Kidney Disease

The Therapeutic Strategies for Uremic Toxins Control in Chronic Kidney Disease

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Inhibition of Inflammatory Cytokine Expression Prevents High-Fat Diet-Induced Kidney Injury: Role of Lingonberry Supplementation

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