“…Considering the advantages and disadvantages of these two techniques, some researchers have adopted hybrid approaches incorporating both mathematical optimization and simulation techniques (Acar, 2007;Butler, Karwan, & Sweigart, 1992;Dijk & Sluis, 2006;Lee et al, 2006;Lin et al, 2000;Moore, Warmke, & Gorban, 1991;Muriel, Anand, & Yongmei, 2006;Qi & Bard, 2006;Smith et al, 2007;Tang & Liu, 2007). A few researchers have used these two techniques iteratively, by returning values from simulation for re-optimization to solve specific problems, exchanging problem-specific parameters between the two techniques (Byrne & Hossain, 2005;Carlson, Hershey, & Kropp, 1979;De Angelis, Felici, & Impelluso, 2003;Karabakal, Gunal, & Ritchie, 2000;Ko, Ko, & Kim, 2006;Lee, Kim, & Moon, 2002;Leung & Cheung, 2000;Leung, Maheshwari, & Miller, 1993;Nolan & Sovereign, 1972). This paper introduces a novel solution methodology that integrates optimization and simulation and is easily adaptable to various combinatorial problems such as those of facility location, facility layout, and scheduling.…”