Shipbuilding materials are characterized by diverse kinds, large quantities and wide distribution of suppliers, which make the supply network complicated. Complex networks have led to increasing uncertainties that may cause disruptions in the supply chain. Flexibility is an effective measure to cope with uncertainty, thus this paper aims to integrate flexibility into the supply chain of shipbuilding materials and explore supply, logistics, organization and quality flexibility by focusing on the requirements of shipbuilding enterprises. This paper combines Quality Function Deployment (QFD), fuzzy theory and Decision Making Trial and Evaluation Laboratory (DEMATEL) methods to guide practical design. After determining five customer requirements (CRs) and 24 design requirements (DRs), QFD links CRs and DRs to determine the most important feasible DRs for improvement of supply chain flexibility. Research results reveal that the most important design requirements can be summarized into four aspects, namely domestic procurement, supply chain member cooperation, supplier supervision, and emergency response construction. Moreover, it is found that long-term strategic partnerships with suppliers and strategic logistics outsourcing are effective strategies. This paper provides insight into implications for strategic decisions of shipbuilding enterprises.