This study first provides a comparative analysis of the impact of supply chain management (SCM) and information systems (IS) practices on operational performance of small and medium-sized enterprises (SMEs) operating in two neighboring emerging country markets of Turkey and Bulgaria. Then, we investigate moderating effects of both SCM-IS linked enablers and inhibitors on the links between SCM and IS practices and operational performance of SMEs. To this end, we first empirically identify the underlying dimensions of SCM and IS practices, and SCM-IS related enabling and inhibiting factors. Second, a series of regression analyses is undertaken to estimate the impact of the study's constructs on operational performance of SMEs. The results are discussed comparatively within the contexts of both Turkish and Bulgarian SMEs and beyond. The study makes a significant contribution to the extant literature through obtaining and analyzing cross-national survey data of SCM and IS practices in emerging country markets.