Supported Ionic Liquid Phase (SILP) Allylic Alkylation of Amines in Continuous Flow

Abstract

We present the use of Pd‐complex‐containing supported ionic liquid phases (SILPs) as a novel approach for continuous‐flow allylic alkylation of N‐nucleophiles. This immobilization strategy gave simple access to air‐tolerating catalyst frameworks, providing rapid and convenient access to various achiral and chiral N‐allylation products. Under optimized conditions, the flow‐reaction could be maintained for 3.5 hours with constant product output; meanwhile, only a marginal 0.7 wt % of ionic liquid leaching and no detectable palladium‐complex leaching could be observed.