A facile and highly efficient protocol for the one‐pot, four‐component synthesis of polysubstituted 2‐aminopyrroles by using glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile has been developed. Meglumine used as an inexpensive, biodegradable and reusable catalyst. Simplicity, green solvent, easy work‐up process, cost effective and reusability of the promoter are the main advantages of reported methodology.