Supporting innovation against the threat of antibiotic resistance: Exploring the impact of public incentives on firm performance and entrepreneurial orientation

Ciabuschi, Francesco; Baraldi, Enrico; Lindahl, Olof; Callegari, Simone

doi:10.1016/j.jbusres.2019.12.021

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Of the 42 articles included for analysis, 21 compared two or more incentive models to determine which one(s) were superior to the others. 18 , 19 , 23 , 28 , 29 , 31 , 34 , 37–50 Thirty-eight articles recommended a particular push incentive, pull incentive, or a push-pull hybrid model. 1 , 17 , 18 , 20–23 , 25 , 28 , 29 , 31 , 32 , 35–60 In terms of the four that did not make a recommendation, two of the studies simply reviewed different incentives and outlined possible benefits and disadvantages of each without offering a final recommendation, 19 , 34 one focused on analyzing the disadvantages associated with exclusivity extension pull strategies, 61 and the last paper did not support any push or pull financial incentives.…”

Section: Resultsmentioning

confidence: 99%

“…The incentive strategy that was the most recommended among the included articles was a mix/hybrid model, suggested by 15 articles. 18 , 20–23 , 29 , 31 , 32 , 36 , 37 , 42 , 46 , 51 , 52 , 57 However, there was no consensus among authors on what a hybrid model should or could look like. The specific push and pull components varied from one article to the next, with many of the articles not specifying which particular push or pull incentives they would suggest for the model ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…42 Interestingly, five of the 15 articles suggesting a mix/hybrid model included an MER as one of the components for their suggested model. 31 , 37 , 42 , 46 , 51 , 52 …”

Section: Resultsmentioning

confidence: 99%

“…Other components of recommended mix/hybrid models consisted of research grants, 21 , 23 , 31 , 42 , 46 , 52 advance market commitments, 23 , 42 , 46 tax credits, 51 conservation-based market exclusivity, 42 and open-source drug development. 32 , 57 Three articles did not elaborate on the characteristics of their proposed mix/hybrid models, focusing instead on advocating for the strengths of concurrently implementing multiple mechanisms as opposed to just one on a general level.…”

Section: Resultsmentioning

confidence: 99%

“…Financial incentives that motivate investment in antibiotics by drug companies can be classified into either push or pull mechanisms, whereby push mechanisms focus on decreasing antibiotic development costs and pull mechanisms aim to increase or ensure adequate market revenue for newly approved antibiotics (further discussed in the results section). 18 , 19 , 29 , 31 , 32 …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Encouraging the Development of New Antibiotics: Are Financial Incentives the Right Way Forward? A Systematic Review and Case Study

Dutescu¹,

Hillier²

2021

IDR

109

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Antibiotic resistance is an urgent public health threat that has received substantial attention from the world’s leading health agencies and national governmental bodies alike. However, despite increasing rates of antibiotic resistance, pharmaceutical companies are reluctant to develop new antibiotics due to scientific, regulatory, and financial barriers. Nonetheless, only a handful of countries have addressed this by implementing or proposing financial incentive models to promote antibiotic innovation. This study is comprised of a systematic review that aimed to understand which antibiotic incentive strategies are most recommended within the literature and subsequently analyzed these incentives to determine which are most likely to sustainably revitalize the antibiotic pipeline. Through a case study of Canada, we apply our incentive analysis to the Canadian landscape to provide decision-makers with a possible path forward. Based on our findings, we propose that Canada support the ongoing efforts of other countries by implementing a fully delinked subscription-based market entry reward. This paper seeks to spark action in Canada by shifting the national paradigm to one where antibiotic research and development is prioritized as a key element to addressing antibiotic resistance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…42 Interestingly, five of the 15 articles suggesting a mix/hybrid model included an MER as one of the components for their suggested model. 31 , 37 , 42 , 46 , 51 , 52 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Encouraging the Development of New Antibiotics: Are Financial Incentives the Right Way Forward? A Systematic Review and Case Study

Dutescu¹,

Hillier²

2021

IDR

109

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Institutions, innovation and performance in Guangdong firms: The role of entrepreneurial orientation and environmental turbulence

Petti,

Compagnucci,

Tang

2023

Int Entrep Manag J

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Impact of government support policies on entrepreneurial orientation and SME performance

Prasannath,

Adhikari,

Gronum

et al. 2024

Int Entrep Manag J

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Small and medium enterprises (SMEs) are often resource-constrained and motivated by necessity or opportunity. They play an essential role in national economies due to their contributions to employment, human capital development, knowledge spillovers, and social mobility in maintaining diverse entrepreneurial ecosystems. Government support policies (GSP), both financial and nonfinancial, can directly impact SME performance or indirectly by developing an entrepreneurial orientation (EO). Few studies have investigated the important question of how GSP simultaneously may impact both the EO and the performance of an SME. Thus, this paper aims to identify the current understanding of how different forms of GSPs relate to and impact the EO and the performance of SMEs. A systematic literature review was conducted using the PRISMA methodology to synthesize this understanding, resulting in 65 relevant articles from the ABI/INFORM, ScienceDirect, Scopus and Web of Science databases. The relationships between the constructs were analyzed using thematic and semantic analyses, employing computer-assisted data analysis software (NVivo 12 and Leximancer 4.5). This resulted in the categorization of GSPs as direct and indirect support policies, with financial and nonfinancial-subcategories, and depicted their pathways of influence on SMEs’ EO and performance. The study found that GSPs have four different pathways by which they can impact performance. Both direct and indirect policies have moderating effects that can magnify the impact of EO on performance. The review established that the direct effect of GSP on EO varies by sector, SME growth-intention, and type of GSP. Based on the findings, we recommend policymakers develop support policies tailored to SMEs’ specific sector and its intentions to enhance performance.

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Supporting innovation against the threat of antibiotic resistance: Exploring the impact of public incentives on firm performance and entrepreneurial orientation

Cited by 16 publications

References 24 publications

Encouraging the Development of New Antibiotics: Are Financial Incentives the Right Way Forward? A Systematic Review and Case Study

Encouraging the Development of New Antibiotics: Are Financial Incentives the Right Way Forward? A Systematic Review and Case Study

Institutions, innovation and performance in Guangdong firms: The role of entrepreneurial orientation and environmental turbulence

Impact of government support policies on entrepreneurial orientation and SME performance

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