The purpose of this study was to examine attitudes toward the voluntary practice of eugenics among people with high-risk inheritable diseases and genetic disorders. Participants consisted of 426 students attending two large public universities in the south and southwestern regions of the United States. The study used the modified scale of attitudes toward mental retardation and eugenics, the risk-taking questionnaire, and the dimensions of religious ideology importance scale. A general linear model was tested to answer the research question. The results showed that the model was significant (p < 0.001; adjusted r2 of 0.078). Significant main effects were found in race [F (4,378) = 2.538, p = 0.04, η² = 0.026], risk avoidance [F (1,378) = 12.536, p < 0.001, η² = 0.032] and importance of religion [F (1,378) = 5.530, p = 0.019, η² = 0.014]. Cultural, ethnic, and religious variables influenced people's views toward disability. One's perception of both disability and its impact on quality of life will influence his or her feelings about eugenics and babies with congenital conditions.