2024
DOI: 10.1002/advs.202412514
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Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Mi Zhou,
Pengju Yu,
Chengcheng Hu
et al.

Abstract: Antifungal resistance, particularly the rise of multidrug‐resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug‐resistance gene, msp‐8, encoding a helicase, through experimental evolution with Neurospora crassa as a model. Deletion of msp‐8 conferred multidrug resistance in N. crassa, Aspergillus fumigatus, and Fusarium verticillioides. However, the transcript levels of genes encoding known drug targets or efflux pumps remain unaltered with msp‐8 de… Show more

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