Suppressed T Cell-Mediated Immunity in Patients with COVID-19: A Clinical Retrospective Study in Wuhan, China

Xu, Bo; Fan, Cun-yu; Wang, Anlu; Zou, Yilong; Yu, Yihan; He, Cong; Xia, Wenguang; Zhang, Jixian; Miao, Qi

doi:10.2139/ssrn.3558005

Cited by 6 publications

(4 citation statements)

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“…The 45 studies included 16,561 patients from 17 countries from December 29, 2019, to July 30, 2020. There were 16 studies from Europe (n ¼ 13,485), [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] 15 studies from China (n ¼ 1,385), [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] 11 studies from North America (n ¼ 1,469), [52][53][54][55][56][57][58][59][60][61][62] and three studies from Middle East (n ¼ 222). [63][64][65] There were 18 case series, 22,24,25,29,…”

Section: Resultsmentioning

confidence: 99%

Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU

Tan

Song

Deane

et al. 2021

Chest

159

118

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Background The COVID-19 pandemic has placed unprecedented burden on the delivery of intensive care services worldwide. Research question What is the global point estimate of mortality and risk factors for patients admitted to intensive care units (ICUs) with severe COVID-19? Methods In this systematic review and meta-analysis Medline, Embase and the Cochrane library were searched up to 1 August 2020. Pooled prevalence of participant characteristics, clinical features and outcome data were calculated using random effects models. Subgroup analyses were based on geographical distribution, study type, quality assessment, sample size, end date and patient disposition Results Forty-five studies with 16561 patients from 17 countries across four continents were included. Patients with COVID-19 admitted to ICU had a mean age of 62·6 years (95%CI 60.4-64·7). Common comorbidities included hypertension (49·5% (44·9-54·0)) and diabetes (26·6% (22·7-30·8)). Over three-quarters developed Acute Respiratory Distress Syndrome (76·1% (65·7-85·2)). Invasive mechanical ventilation was required in 67.7% (59.1-75.7), vasopressor support in 65·9% (52.4-78.4), renal replacement therapy in 16·9% (12.1-22·2) and extracorporeal membrane oxygenation in 6·4% (4·1-9.1). The duration of ICU and hospital admission was 10·8 days (9·3-18·4) and 19·1 days (16·3-21·9) respectively with in-hospital mortality of 28·1% (23·4-33·0, I 2 96%). No significant subgroup effect was observed. Interpretation Critically ill patients with COVID-19 who are admitted to ICU require substantial organ support and prolonged ICU and hospital level care. The pooled estimate of global mortality for severe COVID-19 is <1/3.

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Section: Resultsmentioning

confidence: 99%

Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU

Tan

Song

Deane

et al. 2021

Chest

159

118

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“…Patients with COVID-19 present with a severe reduction in serum T cells, CD4+, CD8+ T cells, and B-cells, particularly those who need an intensive care unit. previous studies found that J o u r n a l P r e -p r o o f the total T cells, CD4+ T cells, or CD8+ T cells are less than 800, 400, or 300/μL, respectively, and these are inversely correlated with the patient's survival rate (Diao et al, 2020;Xu et al, 2020). As a compensatory mechanism, the body increases serum CRP, IL-6, IL-10, TNF-α, and immunoglobins (IgA, IgM, and IgG) to counteract COVID-19 (Chao et al, 2020;Xu et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

“…previous studies found that J o u r n a l P r e -p r o o f the total T cells, CD4+ T cells, or CD8+ T cells are less than 800, 400, or 300/μL, respectively, and these are inversely correlated with the patient's survival rate (Diao et al, 2020;Xu et al, 2020). As a compensatory mechanism, the body increases serum CRP, IL-6, IL-10, TNF-α, and immunoglobins (IgA, IgM, and IgG) to counteract COVID-19 (Chao et al, 2020;Xu et al, 2020). IgA plays a critical role in humoral immunity and it is the most critical immunoglobulin to fight viruses in the respiratory and digestive systems at the point of virus entrance.…”

Section: Introductionmentioning

confidence: 98%

The effect of aerobic exercise on immune biomarkers and symptoms severity and progression in patients with COVID-19: A randomized control trial

Mohamed

Alawna

2021

Journal of Bodywork and Movement Therapies

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The severity of the disease is influenced by factors such as older age, obesity and metabolic syndrome (8,9). Acute infection with SARS-CoV-2 is associated with lymphopenia in approximately 80% of patients (6,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Furthermore, lymphopenia with the suppression of B, helper (CD4+) and cytotoxic (CD8+) T cell function, is an indicator of a poor clinical outcome (10-15, 17-19, 21-27).…”

Section: Introductionmentioning

confidence: 99%

Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System

et al. 2020

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COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outcome. As CD4+ T cells play a critical role in orchestrating responses against viral infections, important lessons can be drawn by comparing T cell response in COVID-19 and in HIV infection and by studying HIV-infected patients who became infected by SARS-CoV-2. We critically reviewed host characteristics and hyper-inflammatory response in these two viral infections to have a better insight on the large difference in clinical outcome in persons being infected by SARS-CoV-2. The better understanding of mechanism of T cell dysfunction will contribute to the development of targeted therapy against severe COVID-19 and will help to rationally design vaccine involving T cell response for the long-term control of viral infection.

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Suppressed T Cell-Mediated Immunity in Patients with COVID-19: A Clinical Retrospective Study in Wuhan, China

Cited by 6 publications

References 0 publications

Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU

Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU

The effect of aerobic exercise on immune biomarkers and symptoms severity and progression in patients with COVID-19: A randomized control trial

Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System

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