2010
DOI: 10.1371/journal.pone.0012940
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Suppressing an Anti-Inflammatory Cytokine Reveals a Strong Age-Dependent Survival Cost in Mice

Abstract: BackgroundThe central paradigm of ecological immunology postulates that selection acts on immunity as to minimize its cost/benefit ratio. Costs of immunity may arise because the energetic requirements of the immune response divert resources that are no longer available for other vital functions. In addition to these resource-based costs, mis-directed or over-reacting immune responses can be particularly harmful for the host. In spite of the potential importance of immunopathology, most studies dealing with the… Show more

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Cited by 16 publications
(16 citation statements)
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References 33 publications
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“…Alternatively, the transient nature of the exaggerated neuroinflammatory rise in tumor-bearing rats may be a consequence of disease-burdened metabolic constraints. Inflammation, and in particular, excessive inflammation, requires significant energetic resources (Belloni et al, 2010), which may be unsustainable in rats that are simultaneously supporting the growth of a tumor.…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, the transient nature of the exaggerated neuroinflammatory rise in tumor-bearing rats may be a consequence of disease-burdened metabolic constraints. Inflammation, and in particular, excessive inflammation, requires significant energetic resources (Belloni et al, 2010), which may be unsustainable in rats that are simultaneously supporting the growth of a tumor.…”
Section: Discussionmentioning
confidence: 99%
“…As the majority of cancer patients are elderly, these results imply that systemically blocking the IL-10 receptor should be evaluated carefully. 38…”
Section: Balancing Induction and Suppression Of Tumor Immunitymentioning
confidence: 99%
“…IL‐10 inhibition caused high mortality in older animals, whereas no mortality was observed in young animals. As the majority of cancer patients are elderly, these results imply that systemically blocking the IL‐10 receptor should be evaluated carefully 38…”
Section: Balancing Induction and Suppression Of Tumor Immunitymentioning
confidence: 99%
“…Immunologists using animal models are often less focused on side effects than on efficacy. However, more researchers are starting to become aware that in order for preclinical animal models to be more representative to the human situation, lower doses of immune stimulating agents should be used, and toxic side effects in animal models should be meticulously analyzed 38, 41, 42…”
Section: Local Immune Therapy: Targeting the Tumor Microenvironment Amentioning
confidence: 99%