Suppressing the morning rise in cortisol impairs free recall

Rimmele, Ulrike; Meier, Flurina; Lange, Tanja; Born, Jan

doi:10.1101/lm.1728510

Cited by 62 publications

(50 citation statements)

References 49 publications

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“…Such memory and cognitive impairments are rescued by the regeneration of CORT rhythm by the combination of implant of the CORT pellet and oral CORT treatment, only during the awake phase. Even in humans, the retrieval of emotional and neutral texts is impaired by the suppression of the morning rise in cortisol (Rimmele et al 2010). The current results are useful to explain the mechanisms of these diurnal changes of memory performance.…”

Section: Concentration-dependent Functions Of Non-stress Level Of Cormentioning

confidence: 94%

Hippocampal spine changes across the sleep–wake cycle: corticosterone and kinases

Ikeda¹,

Hojo²,

Komatsuzaki³

et al. 2015

Journal of Endocrinology

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The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive to CORT, since glucocorticoid receptors are highly expressed. In rat hippocampus fixed in a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased upon waking (within 3 h), as compared with the spine density in the sleep state. Particularly, the large-head spines increased. The observed change in the spine density may be due to the change in the hippocampal CORT level, since the CORT level at awake state (w30 nM) in cerebrospinal fluid was higher than that at sleep state (w3 nM), as observed from our earlier study. In adrenalectomized (ADX) rats, such a wake-induced increase of the spine density disappeared. S.c. administration of CORT into ADX rats rescued the decreased spine density. By using isolated hippocampal slices, we found that the application of 30 nM CORT increased the spine density within 1 h and that the spine increase was mediated via PKA, PKC, ERK MAPK, and LIMK signaling pathways. These findings suggest that the moderately rapid increase of the spine density on waking might mainly be caused by the CORT-driven kinase networks.

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Section: Concentration-dependent Functions Of Non-stress Level Of Cormentioning

confidence: 94%

Hippocampal spine changes across the sleep–wake cycle: corticosterone and kinases

Ikeda¹,

Hojo²,

Komatsuzaki³

et al. 2015

Journal of Endocrinology

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“…As a key dynamic measure, the CAR too has been linked to cognitive performance. Pharmacological suppression of the CAR, for example, has been shown to impair free recall in comparison to placebo control (Rimmele et al, 2010). In addition the CAR has been shown to be attenuated in patients with memory disorders related to hippocampal damage (Buchanan et al, 2004;Wolf et al, 2005).…”

Section: Introductionmentioning

confidence: 98%

The diurnal cortisol cycle and cognitive performance in the healthy old

Evans

Fredhoi

Loveday

et al. 2011

International Journal of Psychophysiology

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“…In research on low-income children in Head Start, those with higher cortisol reactivity had better cognition and behavior outcomes than children without a cortisol response (Blair et al, 2005). When the CAR is synthetically suppressed in adults, recall of text and pictures learned 3 days earlier is reduced (Rimmele, Meier, Lange, & Born, 2010).…”

Section: Individual Differences and Coping With Intrinsic Stressmentioning

confidence: 99%

Stress, Sleep, and Performance on Standardized Tests: Understudied Pathways to the Achievement Gap

Heissel¹,

Levy

Adam³

2017

AERA Open

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Children from low-socioeconomic status (SES) and racial-/ethnic-minority groups score lower on average on standardized academic tests relative to high-SES and White families, respectively (Bradbury, Corak, Waldfogel, & Washbrook, 2015;Reardon, 2011). Many factors contribute to the achievement gap, including class size, teacher characteristics, parent participation, and hunger and nutrition (Barton & Coley, 2009). Although acknowledging these factors, the present paper focuses on an understudied component of the achievement gap: how biological stress responses associated with stress exposure affect performance on standardized tests. Stress exposures come from school, home, and neighborhood factors and can affect the functioning of multiple stresssensitive biological systems. We focus here on two such systems: the hypothalamic-pituitary-adrenal (HPA) axis and sleep. As we show, stress-related alterations in these systems can affect students' learning and test-taking experience. We argue that achievement gaps are at least partly driven by differential stress exposure and biological stress responses between groups. The Stress Disparity ModelHere we provide a brief overview of a theoretical model of how stress exposure and resulting biological stress responses might affect academic achievement as measured by standardized tests. We call this model the stress disparity model. Figure 1 displays the pathways of this model; Figure 2 focuses on the outcomes measured as an achievement gap. We present evidence for this model throughout the paper.We begin by noting that low-SES and racial-/ethnicminority children are more likely to be exposed to stressful life events relative to higher-income or White students (Pathway A; Hatch & Dohrenwend, 2007;Repetti, Taylor, & Seeman, 2002

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Suppressing the morning rise in cortisol impairs free recall

Cited by 62 publications

References 49 publications

Hippocampal spine changes across the sleep–wake cycle: corticosterone and kinases

Hippocampal spine changes across the sleep–wake cycle: corticosterone and kinases

The diurnal cortisol cycle and cognitive performance in the healthy old

Stress, Sleep, and Performance on Standardized Tests: Understudied Pathways to the Achievement Gap

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