Suppression by ?9-tetrahydrocannabinol of induction of hepatic tyrosine aminotransferase and tryptophan oxygenase*1, *2

Friedman, Marvin A.; Wrenn, Jacqueline M.

doi:10.1016/0041-008x(77)90035-7

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Cited by 11 publications

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2‐Chlorethanol [MAK Value Documentation in German language, 1983]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 9. Lieferung, Ausgabe 1983 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde Zur Frage einer mutagenen und cancerogenen Wirkung Begründung des MAK‐Wertes

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2‐Chlorethanol [MAK Value Documentation in German language, 1983]

2012

The MAK‐Collection for Occupational Health and Safety

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Toxicokinetics of chloroethanol in the rat after single oral administration

Grunow

Altmann

1982

Arch Toxicol

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The excretion and tissue distribution of 14C-labelled chloroethanol were studied in rats following single oral administration of 5 and 50 mg/kg body weight. At both dose levels, the radioactivity was rapidly eliminated, mainly in the urine. On the first day after application of 5 mg/kg body weight, 77.2% of the dose were found in the urine, 1.7% in the faeces, and 1.0% as carbon dioxide in the expired air. Only 2.8% were excreted by these routes during the following 3 days. The residual radioactivity remaining in the tissues after 4 days was almost equally distributed and amounted to about 0.4% of the dose in the liver and 3% in the whole organism. At the higher dose level, excretion rates and tissue concentrations were similar. Examination of the urine by anion exchange chromatography on DEAE-Sephadex revealed two metabolites which were identified by GC/MS analysis as thiodiacetic acid and thionyldiacetic acid. These metabolites represented almost the whole urinary radioactivity. They were excreted in approximately equal amounts at the low dose whereas the thiodiacetic acid predominated with about 70% of the urinary radioactivity at the high dose. Unchanged chloroethanol, chloroacetic acid, S-carboxymethylcysteine and sulphonyldiacetic acid were not found in the urine.

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