Suppression by ellagic acid of carbon tetrachlorideor 60Co-irradiation-induced lipid peroxidation in rats.

Protective Effect of Chlorogenic Acid on Lipid Peroxidation Induced in the Liver of Rats by Carbon Tetrachloride or 60Co-Irradiation.

“…Ellagic acid or Toc also suppressed significantly the level at their doses of 20 ,u mol/kg body weight/ day or 100 p mol/kg body weight/day, respectively. These results are also in good agreement with those reported in our previous papers [13,14]. We found that a 20-times larger amount, 400 ,u mol/kg body weight/day, of chlorogenic acid was necessary to decrease the lipid peroxide level of the liver to a similar extent as observed with ellagic acid (20 ,u mol/kg body weight/day).…”

“…These values are in good agreement with normal values obtained in our previous studies [13,14] . When CC14 was given, the lipid peroxide level of the liver measured 24 h after the administration was increased to 652±0.63 .nmol/mg protein (Table 1).…”

“…Recently we found, using rats, that ellagic acid, a component of Eucalyptus maculata, and curcumin, a component of Curcuma longa, are also useful [13,14]. Chlorogenic acid, similar to curcumin, possesses two phenolic hydroxyl groups in its molecular structure (see Fig.…”

Suppressive Effect of Astaxanthin on Lipid Peroxidation Induced in Rats.

“…Astaxanthin decreased significantly the lipid peroxide levels of the liver of rats administered CC14 at a dose of 51umol/kg body weight/day and decreased it even further at a dose of 20 p mol/kg body weight/day. Ellagic acid and Toc decreased significantly the levels at their doses of 20 and 2001u mol/kg body weight/day, respectively, and these results were in good agreement with the values reported previously [9][10][11]. The suppressive effects of astaxanthin, ellagic acid, and Toc on the leakage of GOT and GPT were in parallel with their effects on the liver lipid peroxide level.…”

“…Therefore, we have regarded suitable antioxidants as prophylactics for these diseases, and have been examining their effects by in vivo experiments. As a result, we have found some antioxidants to be promising [6][7][8][9][10][11]. Since astaxanthin is expected to be antioxidant from its molecular structure (see Fig.…”