Suppression by Fucoidan of Liver Fibrogenesis<i>via</i>the TGF-β/Smad Pathway in Protecting against Oxidative Stress

Hong, Sang–Won; Jung, Kyung Hee; Lee, Hee-Seung; Zheng, Hongmei; Choi, Myung‐Joo; Lee, Chongmu; Hong, Sung Kyung

doi:10.1271/bbb.100599

Cited by 45 publications

(34 citation statements)

References 50 publications

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“…As seen from the data, porphyran had a similar or better effect than the drug Zhibituo. Other studies have also provided additional evidence on the liverprotective function of polysaccharides extracted from seaweed (Hayashi et al 2008;Saito et al 2006;Hong et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet

et al. 2015

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Porphyran is a sulfated polysaccharide extracted from Pyropia, a genus of marine red algae. In this study, the biological activity of porphyran from Pyropia yezoensis as an oral hypolipidemic agent in Institute of Cancer Research (ICR) mice was investigated. Porphyran lowered serum triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio 28 days after administration. Porphyran at a dose of 200 mg kg −1 d −1 can decrease the percentage of body weight gain (BWG) and serum lipid profiles of mice significantly, similar to Zhibituo (a hypolipidemic drug approved by the China Food and Drug Administration in 2009). The mice that have taken porphyran showed an obvious increase in the fecal TC and TG compared with the blank control group. The liver weight, lipid composition (TG and TC), liver damage index (serum alanine aminotransferase, ALT; aspartate aminotransaminase, AST; and alkaline phosphatase, ALP), and hepatocyte morphology results in mice on a high-fat diet imply that dietary administration of porphyran can alleviate liver damage induced by the diet. Therefore, porphyran may be useful as a functional food additive, hypolipidemic, and liver-protective agent.

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Section: Discussionmentioning

confidence: 99%

Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet

et al. 2015

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“…Pre-treating rats with fucoidan preparations caused suppression of lactate dehydrogenase and malondialdehyde levels, but caused normalization of superoxide dismutase, catalase, and glutathione peroxidase levels, decreasing necrosis and cirrhosis incidences in the liver of CCL 4 -treated rats [107]. Similarly, fibrosis and acetaminophen-induced liver injury were significantly suppressed by oral fucoidan intake [110,111]. Luo et al investigated the effects of fucoidan on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models of parkinsonism in C57/BL mice.…”

Section: In Vivo Antioxidant and Prooxidant Effects Of Fucoidanmentioning

confidence: 99%

Fucoidan as a Marine Anticancer Agent in Preclinical Development

2014

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Fucoidan is a fucose-containing sulfated polysaccharide derived from brown seaweeds, crude extracts of which are commercially available as nutritional supplements. Recent studies have demonstrated antiproliferative, antiangiogenic, and anticancer properties of fucoidan in vitro. Accordingly, the anticancer effects of fucoidan have been shown to vary depending on its structure, while it can target multiple receptors or signaling molecules in various cell types, including tumor cells and immune cells. Low toxicity and the in vitro effects of fucoidan mentioned above make it a suitable agent for cancer prevention or treatment. However, preclinical development of natural marine products requires in vivo examination of purified compounds in animal tumor models. This review discusses the effects of systemic and local administration of fucoidan on tumor growth, angiogenesis, and immune reaction and whether in vivo and in vitro results are likely applicable to the development of fucoidan as a marine anticancer drug.

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“…The mechanisms appeared to regulate the cholinergic system (increasing the activity of choline acetyl transferase), reduce the oxidative stress (reduced malondialdehyde content in hippocampal tissue of brain) and inhibit the cell apoptosis (increase of Bcl-2/Bax ratio and a decrease of caspase-3 activity). Hong et al (2011) investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats. When administered (100 mg/kg, 3 times per week), fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 [TGF-β (1)]/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9).…”

Section: Therapeutic Potential Of Sulfated Polysaccharidesmentioning

confidence: 99%

Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings

Patel

2012

3 Biotech

155

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Seaweeds, being prolific sources of bioactive components have garnered unprecedented interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. Especially, the sulfated polysaccharides, viz . fucans, carrageenans and ulvans have exhibited strong antioxidant, antitumor, immunostimulatory, anti-inflammatory, pulmonary fibrosis anticoagulant/antithrombotic, lipid lowering, antiviral, antibacterial, antiprotozoan, hyperplasia prevention, gastrointestinal, regenerative and nano medicine applications. Considering the immense biomedical prospects of sulfated polysaccharides, the profound and emerging functional properties published in recent times will be discussed here with experimental evidences. The limitations of the seaweed-derived sulfated polysaccharides in healthcare will be summarized. Strategies to maximize extraction and bioavailability will be pondered.

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Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

Cited by 45 publications

References 50 publications

Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet

Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet

Fucoidan as a Marine Anticancer Agent in Preclinical Development

Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings

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