Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein

Lee, Sun Hwa; Kim, Dae Won; Eom, Seon Ae; Jun, Se‐Young; Park, Meeyoung; Kim, Duk‐Soo; Kwon, Hee Jung; Kwon, Hyeok Yil; Han, Kyu Hyung; Park, Jinseu; Hwang, Hyun Sook; Eum, Won Sik; Choi, Soo Young

doi:10.5483/bmbrep.2012.45.6.036

Cited by 33 publications

(17 citation statements)

References 31 publications

(31 reference statements)

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“…TPA-induced inflammation is also associated with elevation in cytokine such as TNF-a, IL-1b and IL-6 levels in the affected skin tissues 31 . In the present study, topical application of TPA induced a marked increase in ear thickness and weight which was associated with elevated tissue levels of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis

Sharma¹,

Mohapatra²,

Argade

et al. 2014

Immunopharmacology and Immunotoxicology

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Section: Discussionmentioning

confidence: 99%

Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis

Sharma¹,

Mohapatra²,

Argade

et al. 2014

Immunopharmacology and Immunotoxicology

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“…The RNA (2 μg) was reverse transcribed into cDNA with 10,000 U of reverse transcriptase and 0.5 μg/μL oligo-(dT)15 primer (Promega, Madison, WI, USA). PCR amplification of cDNA was performed using specific primers, as described previously (30). The following forward and reverse primers (5'-＞3') were used: ICAM-1 forward, GGT GAC GCT GAA TGG GGT TCC; ICAM-1 reverse, GTC CTC ATG GTG GGG CTA TGA CTC; HO-1 forward, GCG CAG CAT GCC CCA GGA TTT G; and HO-1 reverse, AGC TGG ATG TTG AGC AGG A; beta-actin forward, GCG GGA AAT CGT GCG TGA CAT T; and beta-actin reverse, GAT GGA GTT GAA GGT AGT TTC GTG.…”

Section: Methodsmentioning

confidence: 99%

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells

Youn

Kwon²,

Ju³

et al. 2013

BMB Reports

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Adhesion molecules such as ICAM-1 are important in the infiltration of leukocytes into the site of inflammation. In this study, we investigated the inhibitory effects of curcumin on ICAM-1 expression and monocyte adhesiveness as well as its underlying action mechanism in the TNF-α-stimulated keratinocytes. Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT. In addition, curcumin induced Nrf2 activation in dose- and time-dependent manners in the HaCaT cells. Curcumin suppressed TNF-α- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF-α-induced ICAM-1 expression and adhesion of monocytes to keratinocytes. These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-α-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes. [BMB Reports 2013;46(8): 410-415]

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“…Also, mitogen-activated protein kinase (MAPK) signal pathways play an important role in the inflammatory response (8,9,30). Previously we showed that transduced PEP-1-FK506BP and PTD-fusion proteins inhibit the production of COX-2 and inflammatory cytokines, as well as the activation of NF-κB and MAPKs in LPS-stimulated macrophage cells, and in TPA-treated inflammation animal models (19,20,24,31). Furthermore, Kubo et al .…”

Section: Resultsmentioning

confidence: 99%

Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model

Kim¹,

Lee²,

Ku³

et al. 2013

BMB Reports

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FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h. In addition, we demonstrated that topical application of PEP-1-FK506BP was transduced into mouse cornea and conjunctiva by immunohistochemistry. Furthermore, topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. These results suggest PEP-1-FK506BP as a potential therapeutic agent for dry eye diseases. [BMB Reports 2013; 46(2): 124-129]

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Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein

Cited by 33 publications

References 31 publications

Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis

Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells

Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model

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