Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides

Schafer, Jamie L.; Ries, Moritz; Guha, Natasha; Connole, Michelle; Colantonio, Arnaud D.; Wiertz, Emmanuel J. H. J.; Wilson, Nancy A.; Kaur, Amitinder; Evans, David T.

doi:10.1371/journal.ppat.1005145

Cited by 13 publications

(21 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is interpreted as a strategy to avoid immune recognition and underscores the importance of NK cells in the defence of HIV‐1 . An influence of MHC class I‐bound peptides on binding avidity of KIR3D proteins was also demonstrated in rhesus and pig‐tailed macaques . Hence, there is accumulating evidence that the repertoire of presented peptides is an important factor in the KIR‐mediated control of NK cell activity and that viruses might exploit this.…”

Section: The Kir and Mhc Class I Gene Families Of Macaquesmentioning

confidence: 90%

Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques – implications for highly complex MHC‐dependent regulation of natural killer cells

Walter

Petersen

2016

Immunology

View full text Add to dashboard Cite

The killer immunoglobulin-like receptors (KIR) as well as their MHC class I ligands display enormous genetic diversity and polymorphism in macaque species. Signals resulting from interaction between KIR or CD94/NKG2 receptors and their cognate MHC class I proteins essentially regulate the activity of natural killer (NK) cells. Macaque and human KIR share many features, such as clonal expression patterns, gene copy number variations, specificity for particular MHC class I allotypes, or epistasis between KIR and MHC class I genes that influence susceptibility and resistance to immunodeficiency virus infection. In this review article we also annotated publicly available rhesus macaque BAC clone sequences and provide the first description of the CD94-NKG2 genomic region. Besides the presence of genes that are orthologous to human NKG2A and NKG2F, this region contains three NKG2C paralogues. Hence, the genome of rhesus macaques contains moderately expanded and diversified NKG2 genes in addition to highly diversified KIR genes. The presence of two diversified NK cell receptor families in one species has not been described before and is expected to require a complex MHC-dependent regulation of NK cells.

show abstract

Section: The Kir and Mhc Class I Gene Families Of Macaquesmentioning

confidence: 90%

Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques – implications for highly complex MHC‐dependent regulation of natural killer cells

Walter

Petersen

2016

Immunology

View full text Add to dashboard Cite

show abstract

“…Hence, these results did not reveal an advantage to SIV replication in Mamu-A1*002 + animals as a result of the presentation of inhibitory peptides to KIR3DL05 + NK cells, as in vitro assays with sorted primary NK cells might suggest [16]. However, these findings do not necessarily preclude a contribution of peptides to the evasion of NK cell responses.…”

Section: Discussionmentioning

confidence: 76%

“…These comparisons therefore did not reveal an advantage to SIV replication in Mamu-A1*002 + macaques as a consequence of the presentation of inhibitory peptides to KIR3DL05 + NK cells, as suggested by cell culture experiments with sorted KIR3DL05 + NK cells [16]. …”

Section: Resultsmentioning

confidence: 95%

“…HLA-C molecules can likewise be classified as C1 or C2 allotypes on the basis of polymorphisms at positions 77 and 80, which are recognized respectively by KIR2DL2 and KIR2DL3 or KIR2DL1 depending on the amino acid residues at these positions [10,11]. Consistent with crystal structures showing that KIRs contact HLA class I surfaces over C-terminal peptide residues [12–14], peptides bound by MHC class I ligands can also influence these interactions [15,16]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques

et al. 2017

Self Cite

View full text Add to dashboard Cite

Natural killer cells provide an important early defense against viral pathogens and are regulated in part by interactions between highly polymorphic killer-cell immunoglobulin-like receptors (KIRs) on NK cells and their MHC class I ligands on target cells. We previously identified MHC class I ligands for two rhesus macaque KIRs: KIR3DL01 recognizes Mamu-Bw4 molecules and KIR3DL05 recognizes Mamu-A1*002. To determine how these interactions influence NK cell responses, we infected KIR3DL01+ and KIR3DL05+ macaques with and without defined ligands for these receptors with SIVmac239, and monitored NK cell responses in peripheral blood and lymphoid tissues. NK cell responses in blood were broadly stimulated, as indicated by rapid increases in the CD16+ population during acute infection and sustained increases in the CD16+ and CD16-CD56- populations during chronic infection. Markers of proliferation (Ki-67), activation (CD69 & HLA-DR) and antiviral activity (CD107a & TNFα) were also widely expressed, but began to diverge during chronic infection, as reflected by sustained CD107a and TNFα upregulation by KIR3DL01+, but not by KIR3DL05+ NK cells. Significant increases in the frequency of KIR3DL01+ (but not KIR3DL05+) NK cells were also observed in tissues, particularly in the gut-associated lymphoid tissues, where this receptor was preferentially upregulated on CD56+ and CD16-CD56- subsets. These results reveal broad NK cell activation and dynamic changes in the phenotypic properties of NK cells in response to SIV infection, including the enrichment of KIR3DL01+ NK cells in tissues that support high levels of virus replication.

show abstract

“…In this respect, non‐human primates may be a more suitable alternative model to evaluate the role of inhibitory receptors on neutrophil functions in vivo. Indeed, the characterization of KIR in macaques has improved the understanding of human NK cell immune responses mediated through this family of inhibitory receptors . Non‐human primates are also highly relevant models for several human infectious diseases because of their close phylogenetic relationship with humans.…”

Section: Inhibitory Receptors Expressed On Neutrophils In Humans and mentioning

confidence: 99%

Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

Favier

2016

Immunological Reviews

View full text Add to dashboard Cite

Neutrophils are the most abundant subset of leukocytes and play a crucial role in the immune responses against the daily pathogen attacks faced by the host. Neutrophils exhibit several functions for fighting microbes, including the release of granules containing highly toxic molecules, the production of reactive oxygen species and inflammatory cytokines as well as NETosis. Therefore, immune responses mediated by neutrophils must be tightly regulated to protect the host from pathogen assaults without inducing detrimental inflammation and tissue damage. There is now compelling evidence showing that neutrophils express various inhibitory receptors that specifically control their functions. Some of these inhibitory receptors are contained in the membrane of granules and rapidly move to the cell surface upon neutrophil stimulation. This fast upregulation of inhibitory receptors is an efficient way to rapidly enhance inhibitory signals and increase the neutrophil activation threshold. However, because of their ability to attenuate the immune responses of neutrophils, the inhibitory receptors are attractive target for pathogens. This review discusses these various aspects with a particular emphasis on the regulation of neutrophil behavior through immunoreceptor tyrosine-based inhibition motif (ITIM)-bearing inhibitory receptors belonging to LILR and SIGLEC multi-gene families in humans and animal models.

show abstract

Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides

Cited by 13 publications

References 53 publications

Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques – implications for highly complex MHC‐dependent regulation of natural killer cells

Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques – implications for highly complex MHC‐dependent regulation of natural killer cells

KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques

Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

Contact Info

Product

Resources

About