Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Kang, Suk-Yun; Roh, Dae Hyun; Kim, Hyun Woo; Han, Ho Jae; Beitz, Alvin J.; Lee, Jang Hern

doi:10.1002/j.1532-2149.2013.00410.x

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…Although the experiment was not carried out, we speculate that β-amyloid located at the supraspinal level may further enhance the descending pain inhibitory system, which could lead to decreased p-CREB and p-ERK expression in the spinal cord. Our group and others have previously reported that the adrenal gland is closely involved with regulation of nociception and antinociception (Sim et al, 2013;Kang et al, 2014). An earlier study demonstrated that both CREB and ERK proteins are involved the regulation of adrenal steroidogenesis (Chen et al, 2005).…”

Section: Discussionmentioning

confidence: 88%

The modulatory role of β-amyloid in the regulation of nociception in mice

Feng¹,

Lee²,

Sim³

et al. 2020

Acta Neurobiologiae Experimentalis

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β-amyloid is an important factor in the pathophysiology of Alzheimer's disease.This study investigates β-amyloid's role in the regulation of nociception in mice. Pretreated once, 2 weeks prior to testing with β-amyloid, male ICR mice were examined on various nociceptive tests. Pretreatment with β-amyloid reversed the nociceptive effects induced by intraperitoneally administered acetic acid (writhing response) and intraplantar injection of 5% formalin into the hind paw. β-amyloid pretreatment also elevated the threshold for nociception in the mechanical von Frey test. Additionally, p-CREB and p-ERK levels in the spinal cord and the adrenal gland increased after formalin injection. Pretreatment with β-amyloid attenuated formalin-induced overexpression of p-CREB and p-ERK in the spinal cord and the adrenal gland. Our results suggest that chemical and mechanical nociception appear to be altered in β-amyloid-treated animals. Furthermore, the reduction of nociception by β-amyloid in the formalin pain model appears to be mediated, at least in part, by the suppression of p-CREB and p-ERK level in the spinal cord and the adrenal gland.

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Section: Discussionmentioning

confidence: 88%

The modulatory role of β-amyloid in the regulation of nociception in mice

Feng¹,

Lee²,

Sim³

et al. 2020

Acta Neurobiologiae Experimentalis

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“…There have been previous reports that PNMT inhibition produces antinociception. So, DCMB (2,3-dichloro-α-methylbenzylamine), a PNMT inhibitor, potentiates analgesia produced by corticosterone and bee venom administration in the formalin model of inflammatory pain [50,51]. Interestingly, adrenalectomy mimicked the effect of PNMT inhibition, and systemic administration of A blocked the adrenalectomy-mediated enhancement of antinociception.…”

Section: Discussionmentioning

confidence: 99%

The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain

Arribas-Blázquez

Olivos-Oré

Barahona

et al. 2020

IJMS

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We have investigated whether the stress response mediated by the adrenal medulla in rats subjected to chronic constriction injury of the sciatic nerve (CCI) modulates their nocifensive behavior. Treatment with SK29661 (300 mg/kg; intraperitoneal (I.P.)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw. The effect was fast and reversible and was associated with a decrease in the A to NA ratio (A/NA) in the adrenal gland and circulating blood, an A/NA that was elevated by CCI. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (SKF29661) did not affect exocytosis evoked by Ca2+ entry as well as major ionic conductances (voltage-gated Na+, Ca2+, and K+ channels, nicotinic acetylcholine receptors) involved in stimulus-secretion coupling in chromaffin cells, suggesting that it acted by changing the relative content of the two adrenal catecholamines. Denervation of the adrenal medulla by surgical splanchnectomy attenuated mechanical allodynia in neuropathic animals, hence confirming the involvement of the adrenal medulla in the pathophysiology of the CCI model. Inhibition of PNMT appears to be an effective and probably safe way to modulate adrenal medulla activity and, in turn, to alleviate pain secondary to the injury of a peripheral nerve.

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Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization

Lai

Lin

Hsieh

2019

Evidence-Based Complementary and Alternative Medicine

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Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.

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Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Abstract: These results demonstrate that suppression of epinephrine, derived from adrenal gland, enhances the antinociceptive effect of exogenous corticosterone treatment in an inflammatory pain model.

Cited by 4 publications

References 48 publications

The modulatory role of β-amyloid in the regulation of nociception in mice

The modulatory role of β-amyloid in the regulation of nociception in mice

The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain

Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization

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