Suppression of age-related changes in mouse hippocampal CA3 nerve cells by a free radical scavenger

Asanuma, Akimune; Yamauchi, Yoichi; Koga, Teruji; Katayama, Isao

doi:10.1016/0047-6374(95)01613-5

Cited by 5 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, we demonstrated that dilazep treatment indeed attenuated glomerular sclerosis, suggesting that the vascular protection was observed throughout the systemic circulation. In addition, it has been well documented that dilazep, a nucleoside transporter inhibitor, behaves as an anti-platelet aggregatory drug and an oxygen-radical scavenger, and prevents the appearance of neurological symptoms and brain damage induced by ischemia and reperfusion (5)(6)(7)(8)(9)(10)(11). Unfortunately, we were unable to provide evidence that the scavenging effects of dilazep participated in the preservation of cognition.…”

Section: Discussioncontrasting

confidence: 42%

“…Several long-term clinical trials have revealed that blood pressure control leads to prevention inhibition of platelet aggregation (5,6). In addition, this drug uniquely behaves in vitro as an oxygen-radical scavenger (7). Such multifactorial actions are believed to attenuate mesangial cell proliferation or glomerular injury in immunoglobulin A (IgA) nephropathy (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

View full text Add to dashboard Cite

Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5 g/ml in drinking water) or high-dose dilazep (12.5 g/ml).

show abstract

Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Using an image analyzer (Sumika, Hyogo, Japan), the TrkB-mRNA-positive cells that stained red in the regions of each hemisphere in the hippocampal CA1, CA3, and CA4, amygdaloid body, perirhinal cortex, and the ventromedial nucleus of the thalamus were counted. The landmarks used to identify each site have been previously described (Asanuma et al, 1995). A functional neural basis for the association of higher-order sensory inputs has been identified in the perirhinal cortex; the process of transferring sensory information to the entorhinal-hippocampal circuit is affected by incoming information from the amygdala (Kajiwara et al, 2003).…”

mentioning

confidence: 99%

Effect of tooth loss on spatial memory and trkB‐mRNA levels in rats

et al. 2008

View full text Add to dashboard Cite

The mechanism by which tooth loss accelerates spatial memory impairment is unknown. The purpose of this study was to test the hypothesis that tooth loss affects trkB-mRNA levels and leads to an accelerated decrease in the hippocampal cell density in rats. A radial maze was used to evaluate the spatial memory of male Wistar rats that were categorized based on the number of extracted molar teeth. Number of hippocampal pyramidal cells and the trkB-mRNA expressions in the amygdala, perirhinal cortex, thalamus, and the hippocampal CA1, CA3, and CA4 areas, were evaluated using molecular biological techniques. Seven weeks after tooth extraction, maze performance was significantly lower in each tooth loss group than in the control group, and the number of extracted teeth was inversely proportional to the induction of the trkB-mRNA and the hippocampal cell density. The average weight of rats increased by controlled feeding throughout the experiment without showing a significant difference between the control and experimental groups. The results indicated that, in rats, the spatial memory-linked trkB-mRNA was reduced in association with the tooth loss; this supports the hypothesis and suggests that teeth have a role in the prevention of spatial memory impairment.

show abstract

Effects of the loss and reconstruction of molar occlusal support on memory retrieval and hippocampal neuron density in rats

Kurozumi

Hara

Sakamoto

et al. 2019

Journal of Prosthodontic Research

View full text Add to dashboard Cite

Suppression of age-related changes in mouse hippocampal CA3 nerve cells by a free radical scavenger

Cited by 5 publications

References 35 publications

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Effect of tooth loss on spatial memory and trkB‐mRNA levels in rats

Effects of the loss and reconstruction of molar occlusal support on memory retrieval and hippocampal neuron density in rats

Contact Info

Product

Resources

About