Suppression of allergic reaction by <b>λ</b>‐carrageenan: Toll‐like receptor 4/MyD88‐dependent and ‐independent modulation of immunity

Tsuji, Ryohei; Hoshino, Katsuaki; Noro, Yukihiko; Tsuji, Noriko M.; Kurokawa, Toshiro; Masuda, Takeyuki; Akira, Shizuo; Nowak, Bernadeta

doi:10.1046/j.1365-2222.2003.01575.x

Cited by 96 publications

(76 citation statements)

References 40 publications

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“…Moreover, several studies have shown the effect of carrageenan induced inflammation on inflammatory marker release. Intrapleural administration of carrageenan into the pleural space prompts non-specific inflammatory reactions, which in turn stimulate the activation of innate immunity and peripheral release of TNF-a (Tsuji et al, 2003). In agreement with our results, de Oliveira et al…”

Section: Effect Of Inflammation On Inflammatory Markers Tumor Necrosisupporting

confidence: 93%

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Hassan

Matloub

Aboutabl

et al. 2015

Pharmaceutical Biology

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Context: Cajanus cajan L. (Fabaceae), a food crop, is widely used in traditional medicine. Objectives: The phytochemical composition of C. cajan seeds and evaluation of the antiinflammatory, immunomodulatory, antinociceptive, and antioxidant activities were studied. Materials and methods: Unsaponifiable matter and fatty acids were analyzed by GC and GC/MS. The n-butanol fraction was chromatographed on polyamide column. The anti-inflammatory activity of hexane extract (200 and 400 mg/kg, p.o.) was evaluated using the carrageenan-induced rat paw edema at 1, 2, and 3 h. The serum tumor necrosis factor-a, interleukin-6, and immunoglobulin G levels were detected by ELISA. The hexane extract antinociceptive activity was determined by adopting the writhing test in mice. DPPH radical scavenging, total reduction capability, and inhibition of lipid peroxidation of butanol fraction were evaluated. Results and conclusion: Twenty-one unsaponifiable compounds (mainly phytol, 2,6-di-(t-butyl)-4-hydroxy-4-methyl-2,5-cyclohexadiene-1-one, b-sitosterol, stigmasterol, and campesterol), as well as 12 fatty acids (primarily 9,12-octadecadienoic and palmitic acids) were identified in hexane extract of C. cajan seeds. n-BuOH fraction contains quercetin-3-O-b-D-glucopyranoside, orientin, vitexin, quercetin, luteolin, apigenin, and isorhamnetin. For the first time, quercetin-3-O-b-D-glucopyranoside is isolated from C. cajan plant. The hexane extract (200 and 400 mg/kg) inhibited carrageenaninduced inflammation by 85 and 95%, respectively, 3 h post-carrageenan challenge. This was accompanied by an 11 and 20%, 8 and 13%, respectively, decrease of TNF-a and IL-6, as well as significant decrease in IgG serum levels. Moreover, hexane extract (200 and 400 mg/kg) decreased the number of writhings by 61 and 83%, respectively. The butanol fraction showed DPPH radical scavenging (inhibitory concentration (IC 50 ) value: 9.07 mg/ml). ARTICLE HISTORY

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Section: Effect Of Inflammation On Inflammatory Markers Tumor Necrosisupporting

confidence: 93%

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Hassan

Matloub

Aboutabl

et al. 2015

Pharmaceutical Biology

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“…The generation and expansion of T regulatory cells have been shown to depend on bacterial antigens and DNA (28,40). In line with these findings, several studies have highlighted the effects of bacterial components, through TLR2 and TLR4 signaling, on OT and the allergic response in animal models (2,44,46). Interestingly, in a recent study with humans (45), TLR-mediated inhibition of allergic inflammation by lipopolysaccharide was observed only in atopic children and not in adults.…”

Section: Discussionmentioning

confidence: 82%

Antibiotic Administration Early in Life Impairs Specific Humoral Responses to an Oral Antigen and Increases Intestinal Mast Cell Numbers and Mediator Concentrations

Nutten

Schumann

Donnicola

et al. 2007

Clin Vaccine Immunol

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In this study, we assessed the effect of administering the antibiotic amoxicillin to rat pups on the immune response to orally fed ovalbumin (OVA). We first established that amoxicillin administration durably altered the gut microbiota of these animals. In parallel, we observed that the induction of the specific humoral response to ovalbumin was impaired when it occurred during antibiotic administration to the rat pups. We also examined the consequences of those observations on further allergic reactions. Amoxicillin administration had no significant impact on subsequent sensitization to OVA, as nonexacerbated systemic allergic responses were induced in antibiotic-treated animals. However, increased rat mast cell protease II levels and higher mast cell numbers were detected in their small intestines, independently of the antigen administration. Globally, our data suggest that antibiotic administration early in life negatively affects the specific immune response to a luminal antigen when it is first introduced during antibiotic administration. The increased mast cell numbers and mediator concentrations in the intestinal mucosae of the antibiotic-treated animals may testify to the early stages of an altered immune system homeostasis.

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“…TLR2 was found to be a receptor for peptidoglycan and lipoprotein by dimerizing with TLR6, whereas TLR4 was reported as a lipopolysaccharide and lipoteichoic acid receptor (19,32). Lipoteichoic acids are found in most grampositive bacteria (including lactobacilli), and the induction of oral tolerance to ovalbumin has recently been reported through the stimulation of Th1 cells via TLR4 signaling (33). Hence, L. paracasei could induce and maintain oral tolerance to BLG through the recognition of TLR4 by its lipoteichoic acids, but this hypothesis remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Bacteria on Induction and Maintenance of Oral Tolerance to β-Lactoglobulin in Gnotobiotic Mice

Prioult

Fliss

Pecquet

2003

Clin Vaccine Immunol

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In this study, the effect of Lactobacillus paracasei (NCC 2461), Lactobacillus johnsonii (NCC 533) and Bifidobacterium lactis Bb12 (NCC 362) on the induction and maintenance of oral tolerance to bovine ␤-lactoglobulin (BLG) was investigated in mice. Germfree mice were monocolonized with one of the three strains before oral administration of whey protein to induce tolerance. Mice were then injected with BLG and sacrificed 28 or 50 days after whey protein feeding for humoral and cellular response measurement. Conventional and germfree mice were used as controls. Both humoral and cellular responses were better suppressed in conventional mice than in germfree and monoassociated mice throughout the experiment and better suppressed in L. paracasei-associated mice than in mice colonized with B. lactis or L. johnsonii. The latter two mono-associations suppressed humoral responses only partially and cellular responses not at all. This study provides evidence that probiotics modulate the oral tolerance response to BLG in mice. The mono-colonization effect is strain-dependant, the best result having been obtained with L. paracasei.The oral administration of a dietary antigen results in a mucosal and systemic antigen-specific immunological unresponsiveness called oral tolerance. The establishment of oral tolerance prevents digestive immunoglobulin E (IgE)-mediated hypersensitivity reactions to food antigens and depends on several factors, such as the age of the host, the nature and doses of the antigen, the frequency of feeding, and the protein content of the diet (3,11,21,27).Among the environmental factors, the composition of the intestinal microbiota seems to play an important role in the modulation of oral tolerance. It has been shown that oral administration of various antigens induces tolerance in conventional mice but not in germfree mice (18,31,35). In addition, the oral tolerance response in germfree mice can be restored either by administration of lipopolysaccharide from gram-negative bacteria (35) or by monocolonization of the gut with Bifidobacterium infantis (18,31) or Escherichia coli (18) but not with Clostridium perfringens or Staphylococcus aureus (18). Contrasting results show that germfree mice can be made tolerant to ovalbumin but that the tolerance is maintained for a shorter time than in conventional mice (20, 21), for example 2 to 3 months of systemic IgG suppression after a single feeding (30) compared to 21 days in germfree mice (21). These results show that the intestinal microbiota play a major role in the induction and long-term persistence of oral tolerance, but further experiments are needed to identify which bacteria are the most effective.

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Suppression of allergic reaction by λ‐carrageenan: Toll‐like receptor 4/MyD88‐dependent and ‐independent modulation of immunity

Abstract: lambda-Carrageenan was suggested to be a useful dietary supplement to ameliorate allergic reactions while maintaining oral tolerance-dependent intestinal homeostasis.

Cited by 96 publications

References 40 publications

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Antibiotic Administration Early in Life Impairs Specific Humoral Responses to an Oral Antigen and Increases Intestinal Mast Cell Numbers and Mediator Concentrations

Effect of Probiotic Bacteria on Induction and Maintenance of Oral Tolerance to β-Lactoglobulin in Gnotobiotic Mice

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