Suppression of Alveolar Bone Resorption by Etidronate Treatment for Periodontal Disease: 4- to 5-Year Follow-up of Four Patients

Takaishi, Yoshitomo; Ikeo, Takashi; Miki, Takami; Nishizawà, Yoshiki; Morii, Hirotoshi

doi:10.1177/147323000303100614

Cited by 15 publications

(17 citation statements)

References 12 publications

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“…30–35 There have been conflicting findings, with some studies showing improved clinical outcomes with bisphosphonate therapy 33–35 and others showing no additional benefit. 30,31 However, clinical trials evaluating bisphosphonate therapy to improve surgical outcomes are lacking.…”

Section: Discussionmentioning

confidence: 99%

Teriparatide and Osseous Regeneration in the Oral Cavity

Bashutski¹,

Eber²,

Kinney³

et al. 2010

N Engl J Med

239

174

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BACKGROUND Intermittent administration of teriparatide, a drug composed of the first 34 amino acids of parathyroid hormone, has anabolic effects on bone. Although teriparatide has been evaluated for the treatment of osteoporosis and for the healing of fractures, clinical trials evaluating it for the treatment of osseous conditions of the oral cavity in humans are lacking. METHODS A total of 40 patients with severe, chronic periodontitis underwent periodontal surgery and received daily injections of teriparatide (20 μg) or placebo, along with oral calcium (1000 mg) and vitamin D (800 IU) supplementation, for 6 weeks. The patients were followed for 1 year. The primary outcome was a radiographic linear measurement of alveolar bone level. Secondary outcomes included clinical variables, bone turnover markers in serum and oral fluid, systemic bone mineral density, and quality of life. RESULTS Radiographic linear resolution of osseous defects was significantly greater after teriparatide therapy than after placebo beginning at 6 months, with a mean linear gain in bone at 1 year of 29% as compared with 3% (P<0.001). Clinical improvement was greater in patients taking teriparatide than in those taking placebo, with a reduction in periodontal probing depth of 33% versus 20% (2.42 mm vs. 1.32 mm) and a gain in clinical attachment level of 22% versus 7% (1.58 mm vs. 0.42 mm) in target lesions at 1 year (P = 0.02 for both comparisons). No serious adverse events were reported; however, the number of patients in the study was small. No significant differences were noted with respect to the other variables that were assessed. CONCLUSIONS Teriparatide, as compared with placebo, was associated with improved clinical outcomes, greater resolution of alveolar bone defects, and accelerated osseous wound healing in the oral cavity. Teriparatide may offer therapeutic potential for localized bone defects in the jaw. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT00277706.)

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Section: Discussionmentioning

confidence: 99%

Teriparatide and Osseous Regeneration in the Oral Cavity

Bashutski¹,

Eber²,

Kinney³

et al. 2010

N Engl J Med

239

174

View full text Add to dashboard Cite

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“…Dental X-ray films were taken and alveolar bone density at the root of the first mandibular premolar measured, as described elsewhere [9], using an originally designed image editing software (No. PCT/jp2004/010815).…”

Section: Methodsmentioning

confidence: 99%

“…The dental X-ray film after exposure is then taken into a laptop computer using a scanner. Data and histogram of the al-BMD were recorded on the screen in a few minutes using a software (Bone RightⓇ, Dentalgraphic⋅Com Company) [9, 10]. This technique may also be applied similarly to any tooth in a panorama film covering the whole series of the teeth in an individual.…”

Section: Methodsmentioning

confidence: 99%

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A pilot case–control study on the alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw

et al. 2009

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SummaryAlveolar bone mineral density (BMD) measured by radiography standardized by aluminum step wedge pasted on the film and digitized by a computer system was significantly higher around osteonecrosis lesions than in control cases in a pilot case–control study. High alveolar bone density appears useful as a local risk factor for bisphosphonate-related osteonecrosis of the jaw (BRONJ).IntroductionIn an attempt to find a reliable test method predicting the occurrence of BRONJ in addition to various risk factors suggested, an increase of alveolar bone density near the necrotic lesions was found by computerized radiogrammetry using dental films pasted with an aluminum step wedge (Bone RightⓇ, Dentalgraphic⋅Com Company, Himeji) in six cases of BRONJ.MethodsThe bone mineral density surrounding the osteonecrosis lesions showed distinctly higher density in BRONJ cases compared with age-matched controls. In one subject on bisphosphonate treatment in whom two extractions were simultaneously carried out, BRONJ occurred only at the location with extremely high alveolar bone density, but not at the other site with normal density.ConclusionThis method may be useful in detecting a rise of alveolar BMD frequently occurring near the necrotic lesion in subjects with impending risk for BRONJ.

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“…A precise and accurate computed radiogrammetry method has been developed to measure dental alveolar bone (Bone Right ® , Dental Graphic Ltd, Himeji, Japan) that overcomes the difficulties associated with other methods [28–30]. This technique has been used extensively since 2003, procuring accurate measurements of al-BMD by pasting dental X-ray films with an aluminum wedge.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Alveolar Bone Mineral Density as a Predictor of Lumbar Fracture Probability

et al. 2013

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IntroductionOsteoporosis and tooth loss have been linked with advancing age, but no clear relationship between these conditions has been proven. Several studies of bone mineral density measurements of the jaw and spine have shown similarities in their rate of age-related deterioration. Thus, measurements of jawbone density may predict lumbar vertebral bone density. Using jawbone density as a proxy marker would circumvent the need for lumbar bone measurements and facilitate prediction of osteoporotic spinal fracture susceptibility at dental clinics. We aimed to characterize the correlation between bone density in the jaw and spine and the incidence of osteoporotic spinal fractures.MethodsWe used computerized radiogrammetry to measure alveolar bone mineral density (al-BMD) and dual-energy X-ray absorptiometry to measure lumbar bone mineral density (L-BMD). L-BMD and al-BMD in 30 female patients (average age: 59 ± 5 years) were correlated with various patient attributes. Statistical analysis included area under the curve (AUC) and probability of asymptomatic significance (PAS) in a receiver operating characteristic curve. The predictive strength of L-BMD T-scores (L-BMD[T]) and al-BMD measurements for fracture occurrence was then compared using multivariate analysis with category weight scoring.ResultsL-BMD and al-BMD were significantly correlated with age, years since menopause, and alveolar bone thickness. Both were also negatively correlated with fracture incidence. Category weight scores were −0.275 for a L-BMD(T) <80%; +0.183 for a L-BMD(T) ≥80%; −0.860 for al-BMD <84.9 (brightness); and +0.860 for al-BMD ≥84.9. AUC and PAS analyses suggested that al-BMD had a higher association with fracture occurrence than L-BMD.ConclusionsOur results suggest the possible association between al-BMD and vertebral fracture risk. Assessment of alveolar bone density may be useful in patients receiving routine dental exams to monitor the clinical picture and the potential course of osteoporosis in patients who may be at a higher risk of developing osteoporosis.

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Suppression of Alveolar Bone Resorption by Etidronate Treatment for Periodontal Disease: 4- to 5-Year Follow-up of Four Patients

Cited by 15 publications

References 12 publications

Teriparatide and Osseous Regeneration in the Oral Cavity

Teriparatide and Osseous Regeneration in the Oral Cavity

A pilot case–control study on the alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw

Assessment of Alveolar Bone Mineral Density as a Predictor of Lumbar Fracture Probability

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