Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture

Boudreau, Mary D.; Baker, David G.; Taylor, Hermon; Barker, Steven A.; Means, Jay C.

doi:10.1080/019262301316905291

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…Clinicopathologic changes induced by 2-AA were generally similar to those noted previously by this research group when rats were chronically fed 2-AA for 30 days (3). In the present study, serum glucose, ALT, and bilirubin levels were not affected by IP 2-AA administration at the dosages examined.…”

Section: Resultssupporting

confidence: 90%

Hepatic Toxicity and Recovery of Fischer 344 Rats Following Exposure to 2-Aminoanthracene by Intraperitoneal Injection

Baker

Taylor²,

Lee³

et al. 2001

Toxicol Pathol

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Humans may be exposed to 2-aminoanthracen e (2-AA), a substituted polycyclic aromatic hydrocarbon , and a recognized mutagen and carcinogen , through oral and respiratory routes from contact with a variety of environmenta l sources. For the present study, we sought to evaluate hepatic damage and recovery in Fischer 344 rats following multiple IP injections of 5 mg of 2-AA. Rats were injected weekly for up to 5 weeks. Subgroups were then allowed to recover for 1, 5, or 9 weeks, and biochemical and pathologic changes were evaluated. We observed that weight gains were reduced relative to controls for all groups receiving 2 injections. Serum enzyme levels indicative of liver damage were evident and included alterations in serum aspartate aminotransferase, alkaline phosphatase, total protein, albumin, and globulin. These alterations usually returned to normal by 5 weeks following cessation of 2-AA administration. In contrast, histologic liver changes, including hepatocyt e hypertroph y, biliary hyperplasia with oval cell proliferation, altered foci, nodular hyperplasia, and one hepatocellular adenoma became more severe with time. This experiment demonstrates patterns of hepatic damage and recovery in rats exposed to 2-AA.

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Section: Resultssupporting

confidence: 90%

Hepatic Toxicity and Recovery of Fischer 344 Rats Following Exposure to 2-Aminoanthracene by Intraperitoneal Injection

Baker

Taylor²,

Lee³

et al. 2001

Toxicol Pathol

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Dietary Exposure to 2-Aminoanthracene Induces Morphological and Immunocytochemical Changes in Pancreatic Tissues of Fisher-344 Rats

Boudreau¹,

Taylor²,

Baker³

et al. 2006

Toxicological Sciences

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Toxic chemicals ingested as the result of environmental exposures or other risk factors such as cigarette smoking may increase the risk of developing cancer and other diseases such as diabetes. 2-Aminoanthracene (2-AA) was investigated to determine toxic effects of chronic dietary exposure upon major organ systems including the pancreas. Fisher-344 rats were fed 2-AA (50-100 mg/kg of diet) and euthanized at 14, 30, 63, and 80 days. Growth, tissue histological, immunocytochemical, and clinical pathological end points were examined at each time point. Significantly elevated plasma glucose and glycated hemoglobins and reduced serum protein levels were recognized after 80 days of feeding (100 mg/kg of diet 2-AA group). Similar results were observed in rats exposed to 75 mg/kg of diet but appeared to be absent in the 50-mg/kg group. An unexpected pattern of responses suggestive of diabetic sequelae was observed in a glucose tolerance test conducted during the seventh week. After 63 and 80 days, large cytoplasmic vacuoles in islet cells were observed by light microscopy. In addition, the immunocytochemical study demonstrated beta cell insulin insufficiency at 63 and 80 days. No inflammatory infiltration of the islets was observed. These findings suggest that depletion of secretory granules occurred in the beta cells. Necrotic changes occurred in the acinar cells of the pancreas with increasing duration and dose of 2-AA. The cytological, immunocytochemical, and histological results demonstrate that chronic dietary exposure to 2-amino anthracene alters the endocrine and exocrine pancreas cellular morphology and induces diabetic-like symptoms in the Fisher-344 rat.

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Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture

Cited by 2 publications

References 59 publications

Hepatic Toxicity and Recovery of Fischer 344 Rats Following Exposure to 2-Aminoanthracene by Intraperitoneal Injection

Hepatic Toxicity and Recovery of Fischer 344 Rats Following Exposure to 2-Aminoanthracene by Intraperitoneal Injection

Dietary Exposure to 2-Aminoanthracene Induces Morphological and Immunocytochemical Changes in Pancreatic Tissues of Fisher-344 Rats

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