1998
DOI: 10.1038/sj.onc.1201843
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Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells

Abstract: The Activator Protein-1 (AP-1) complex is a dimeric transcription factor composed of fos and jun proteins that regulates cellular growth and di erentiation. We previously demonstrated a reduction in basal AP-1 transcriptional activity associated with the malignant transformation of human bronchial epithelial (HBE) cells that was, in part, a consequence of decreased c-fos expression. In this study, we investigated the mechanisms underlying the reduction in c-fos expression associated with the malignant transfor… Show more

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Cited by 20 publications
(16 citation statements)
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References 30 publications
(46 reference statements)
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“…5). This is consistent with the recently described suppression of c-fos transcription with the malignant transformation of human bronchial epithelial cells (52). In human bronchial epithelial cells, the suppression of c-fos transcription occurs through a CRE site located in a promoter of the gene.…”
Section: Discussionsupporting
confidence: 92%
“…5). This is consistent with the recently described suppression of c-fos transcription with the malignant transformation of human bronchial epithelial cells (52). In human bronchial epithelial cells, the suppression of c-fos transcription occurs through a CRE site located in a promoter of the gene.…”
Section: Discussionsupporting
confidence: 92%
“…This implies that an alteration of the AP-1 composition might contribute to the dysregulation of dierentiation-speci®c gene expression in malignant BE cells. Consistent with this, a reduction in the basal level AP-1 transcriptional activity, in part due to a decrease in c-fos expression, was demonstrated in malignant BE cells (Lee et al, 1998). Thus, dierential expression and/or activation of AP-1 family members might contribute to epithelial cell carcinogenesis.…”
Section: Discussionsupporting
confidence: 67%
“…MAPK activation had been previously studied in lung tumor cells in vitro (41)(42)(43)(44)(45)(46), but only basal ERK activation was analyzed in detail in a large panel of lung cancer cell lines (47). Thus far, simultaneous evaluation of ERK, JNK, and p38 activation has not been performed in lung cancer either in a relevant number of cell lines or in clinical specimens.…”
Section: Discussionmentioning
confidence: 99%