Suppression of experimental colitis in mice by CD11c+ dendritic cells

Qualls, Joseph E.; Tuna, Halide; Kaplan, Alan M.; Cohen, Donald A.

doi:10.1002/ibd.20733

Cited by 57 publications

(50 citation statements)

References 88 publications

(118 reference statements)

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“…Enhanced DC efferocytosis, due to the lack of CD300f, induced DCs to overproduce TNF-α, which stimulated the production of additional proinflammatory cytokines, particularly IFN-γ, by lamina propria T cells. Accumulation of activated DCs has been observed at the inflamed sites in colons of human IBD patients and mice with experimentally induced colitis (40), with no clear indication as to their role in the disease pathogenesis (30,41). Our data indicate that dysregulation of DC efferocytosis may contribute to chronic gut inflammation.…”

Section: Cd300fmentioning

confidence: 70%

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Lee¹,

Tian²,

Bouladoux³

et al. 2017

Journal of Clinical Investigation

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Section: Cd300fmentioning

confidence: 70%

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Lee¹,

Tian²,

Bouladoux³

et al. 2017

Journal of Clinical Investigation

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“…At present study, MPO levels which reflect the degree of neutrophils influx into tissues (26), of buccal mucosa on D7 and D30 were compared for confirming the different influx of neutrophils. It was found that MPO level of X-D7 group was significantly higher than that of on D30 and this higher MPO level could be attenuated by the treatment of immunosuppressant FK506.…”

Section: Discussionmentioning

confidence: 80%

Neutrophils infiltration is early event of an oral mucosal xenotransplantation model

Wang

Tao²,

Xiang³

et al. 2011

Med Oral

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Introduction: As important effector cells of the innate immune system, neutrophils are involved in rejection of solid organ and/or tissue transplants. But their role in rejection of oral mucosa transplantation (OMT) remains unclear. The aim of this study is to observe the spatial-temporal change of neutrophils during acute rejection of OMT. Methods: In a rat model of oral mucosal xenotransplantation, myeloperoxidase (MPO), an indicator of influx of neutrophils was detected by technique of ELISA on day 7 and 30 (D7, D30) of posttransplantation. Results: On D7, MPO level (6.183±0.416, ×10 2 ng/mg) in the OMT group was significantly higher than in trauma (0.681±0.073, ×10 2 ng/mg) and normal controls (0.262±0.043, ×10 2 ng/mg) (P<0.001, respectively), and this level was found to correlate with the index of submandibular lymph nodes (ILN), an indicator of inflammation of rejection (r=0.909, P<0.05). Moreover, this level was decreased significantly under FK506 treatment (2.103±0.146, ×10 2 ng/mg, P= 0.005). On D30, MPO in the OMT group (1.063±0.096, ×10 2 ng/mg) was lower significantly than that on D7 (P<0.001), although this level was still higher that of normal controls on D30 (0.532±0.112, ×10 2 ng/ mg, P = 0.042). Conclusion: Neutrophils infiltration was an early event of OMT, which may play important roles on acute rejection of OMT.

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“…When mice are pretreated with immunostimulatory DNA sequences before DSS administration, the presence of DCs is protective, partly because of type I IFN release that regulates the recruitment of neutrophils and monocytes and their inflammatory activities in the inflamed colon (62). Conversely, if DCs are ablated before DSS treatment, colitis is exacerbated (63), which suggests that DCs play a protective role in the initial phases of colitis but play a pathogenic role at a later time in disease course. There might be several mechanisms by which resident DCs could protect the colon during the initiation of colitis, but their ability to induce Treg development may play a primary role.…”

Section: Dcs In Intestinal Diseasementioning

confidence: 99%

Dendritic cells in intestinal homeostasis and disease

Rescigno¹,

Sabatino²

2009

J. Clin. Invest.

292

233

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DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

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Suppression of experimental colitis in mice by CD11c+ dendritic cells

Abstract: This study demonstrates that resident DCs can suppress the severity of acute DSS colitis and that regulation of IL-6 production may contribute to DC-mediated control of intestinal inflammation.

Cited by 57 publications

References 88 publications

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Neutrophils infiltration is early event of an oral mucosal xenotransplantation model

Dendritic cells in intestinal homeostasis and disease

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