2022
DOI: 10.1016/j.exer.2022.109158
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Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells

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Cited by 7 publications
(2 citation statements)
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“…Moreover, the expression of EMT marker proteins, which was enhanced by dexa treatment, was reversed upon knocking down CSPG5 , indicating that CSPG5 is involved in the EMT of LEC. Similarly, a study that investigated CSPG5 and the prognosis of hepatocellular carcinoma indicated that CSPG5 is related to the transcription factors EZH2 and B-Myb [ 17 ], which reportedly play critical roles in EMT and cell cycle progression [ 18 , 19 , 20 , 21 ]. These transcription factors are known for their involvement in cell proliferation and differentiation, particularly in cancer cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, the expression of EMT marker proteins, which was enhanced by dexa treatment, was reversed upon knocking down CSPG5 , indicating that CSPG5 is involved in the EMT of LEC. Similarly, a study that investigated CSPG5 and the prognosis of hepatocellular carcinoma indicated that CSPG5 is related to the transcription factors EZH2 and B-Myb [ 17 ], which reportedly play critical roles in EMT and cell cycle progression [ 18 , 19 , 20 , 21 ]. These transcription factors are known for their involvement in cell proliferation and differentiation, particularly in cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…These transcription factors are known for their involvement in cell proliferation and differentiation, particularly in cancer cells. Reportedly, the mRNA levels of EZH2 increase during the posterior capsular opacification in LEC [ 19 , 20 ], and EZH2 regulates EGF-mediated EMT in human LEC [ 20 ]. Dexa further increased the upregulation and translocation of EZH2 and B-Myb into the nucleus of LEC.…”
Section: Discussionmentioning
confidence: 99%