Suppression of Gastrin Release and Gastric Secretion by Gastric Inhibitory Polypeptide (GIP) and Vasoactive Intestinal Polypeptide (VIP)

Villar, Hugo V.; Fender, H. Roberts; Rayford, Phillip L.; Bloom, Stephen R.; Ramus, N I; Thompson, James C.

doi:10.1097/00000658-197607000-00016

Cited by 58 publications

(26 citation statements)

References 16 publications

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“…Immediately after a meal, the pH was high (about 5) so that the enzymes secreted in large quantities could exert their coagulating activity. The pH thereafter decreased progressively towards values more favourable to the overall proteolytic activity of pepsin (Henschel, 1973 ;Roy and Stobo, 1975 Debas and Grossman, 1974 ;Desbuquois, 1978 ;Hacki, 1980 ;McLeay and Bell, 1981) ; others seem to have an inhibitory effect on the secretion of acid (secretin, somatostatin, vasoactive intestinal peptide and glucagon) and enzymes (somatostatin and VIP) (Villar, Fender and Rayford, 1976 ;Arnold and Lankish, 1980 ;Hacki, 1980 ;McLeay and Bell, 1981 The psychic stimuli associated with the morning meal (sight, hearing, smell, taste and ingestion) (Siebers, 1978), as well as the distension of the abomasum, act via the parasympathic nervous system or via histamin, leading to a rapid increase in the secretion of enzymes and electrolytes, if the preruminant calf behaves like a monogastric animal (Davenport, 1968) …”

Section: Methodsmentioning

confidence: 99%

Circadian changes in the abomasal secretions of the preruminant calf

Guilloteau¹,

Toullec²,

Beaufils³

et al. 1983

Reprod. Nutr. Dévelop.

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Summary. The purpose of this study was to investigate the circadian changes in the abomasal secretions (quantities of juice, enzymes and electrolytes) of the preruminant calf. The gastric juice was collected every hour from five calves fitted with an innervated abomasal pouch and given milk twice daily, with a 7-h interval between the morning and the evening meals.The amounts of gastric secretions produced were steady during 24 h, except for changes after the meals. The morning meal caused a considerable increase in secretions of electrolytes and enzymes. The values of CI-, H + , Na+ + and K + ions, chymosin and pepsin in the first postprandial hour were 3.8, 4.1, 3.5, 2.6, 2.4 and 2.1 times higher, respectively, than those of the 24th hour used as prefeeding levels. The influence of the evening meal on secretions of CI-and Na + ions and enzymes was less marked and also more delayed for all electrolytes. Variations in the amounts secreted per hour appeared to be greater for H + + ions than for enzymes, thus the ratios between maximal and minimal quantities observed during the 24-h cycle were 4.6 for H + ions and 2.8 for chymosin.Introduction.

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Section: Methodsmentioning

confidence: 99%

Circadian changes in the abomasal secretions of the preruminant calf

Guilloteau¹,

Toullec²,

Beaufils³

et al. 1983

Reprod. Nutr. Dévelop.

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“…Initially, it was considered an inhibitor of gastric acid secretion, 83,84 but later studies demonstrated glucose-dependent stimulation of insulin secretion by GIP, suggesting an incretin role. 85 In time, the term GIP became synonymous with glucose inhibitory polypeptide.…”

Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning

confidence: 99%

Bariatric surgery and bone disease: from clinical perspective to molecular insights

et al. 2012

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“…Targets for the hormone include fundic cells of the stomach, where GIP has been shown to inhibit acid secretion (49), and ␤-cells of the pancreatic islets, where GIP potentiates insulin release (15,39). Because of its insulin-releasing properties, GIP has been designated a physiological incretin, the proposed substance that mediates the enteroinsular axis and appears to play an important role in the maintenance of glucose homeostasis.…”

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confidence: 99%

Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene

Boylan

Jepeal

Wolfe

2006

American Journal of Physiology-Endocrinology and Metabolism

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-The physiological effects of glucose-dependent insulinotropic polypeptide (GIP) are mediated through specific receptors expressed on target cells. Because aberrant GIP receptor (GIPR) expression has been implicated in abnormal GIP responses associated with type 2 diabetes mellitus and food-induced Cushing's syndrome, we sought to identify factors that regulate the GIPR. We previously demonstrated that sequences between Ϫ1 and Ϫ100 of the GIPR gene were sufficient to direct transcription in a rat insulinoma cell line (RIN38). In the present study, we compared the 5Ј-flanking regions of the rat and human GIPR gene and demonstrated 88% identity within the first 92 bp. Subsequent serial deletion analyses showed that the region between Ϫ85 and Ϫ40 is essential for maximal promoter activity. Within this region, we identified three putative Sp1 binding motifs, located at positions Ϫ77, Ϫ60, and Ϫ50, that can specifically bind both Sp1 and Sp3. Whereas mutation of the Sp1 sites at Ϫ50 and Ϫ60 led to 36 and 40% reduction in promoter activity, respectively, mutation of the Sp1 motif at Ϫ70 did not affect promoter activity. Cotransfection of S2 Schneider cells with GIPR-luciferase chimeric constructs and either Sp1 or Sp3 expression vectors indicated that both Sp1 and the long form of Sp3 activate transcription through binding to the Sp1 sites located between Ϫ100 and Ϫ40. Lastly, chromatin immunoprecipitation analyses revealed that both Sp1 and Sp3 bind to the GIPR promoter region in RIN38 cells. These results indicate that cellspecific expression of GIPR is associated with the binding of the transcription factors Sp1 and Sp3 to the GIPR promoter. gastric inhibitory polypeptide; transcription factors; RIN38 cells; insulinoma; rat-2 cells; chromatin immunoprecipitation assay GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) is a member of the secretin

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Suppression of Gastrin Release and Gastric Secretion by Gastric Inhibitory Polypeptide (GIP) and Vasoactive Intestinal Polypeptide (VIP)

Cited by 58 publications

References 16 publications

Circadian changes in the abomasal secretions of the preruminant calf

Circadian changes in the abomasal secretions of the preruminant calf

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene

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