Suppression of ghost artifacts arising from long T<sub>1</sub> species in segmented inversion‐recovery imaging

Jenista, Elizabeth; Rehwald, Wolfgang G; Chaptini, Nayla; Kim, Han W.; Parker, Michele; Wendell, David C.; Chen, Enn-Ling; Kim, Raymond J.

doi:10.1002/mrm.26554

Cited by 8 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional LGE imaging requires repeated IR pulses with a relatively short recovery time. For tissues that do not take up contrast or have long T1 times, such as pericardial effusion, the time between IR pulses is insufficient to recover longitudinal magnetization; therefore, the oscillations occur between imaging segments [ 15 ]. In contrast, the MOLLI sequence, which is the original image of synthetic LGE, uses only two to three IR pulses and ensures sufficient T1 recovery time, resulting in less artifacts for tissues with long T1 time [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

Lee

Kim

et al. 2022

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

Backgrounds Synthetic late gadolinium enhancement (LGE) images are less sensitive to inversion time (TI) and robust to motion artifact, because it is generated retrospectively by post-contrast T1-mapping images. To explore the clinical applicability of synthetic LGE, we investigated the image quality and diagnostic accuracy of synthetic LGE images, in comparison to that of conventional LGE for various disease groups. Method and materials From July to November 2019, a total of 98 patients who underwent cardiovascular magnetic resonance imaging (CMR), including LGE and T1-mapping sequences, with suspicion of myocardial abnormality were retrospectively included. Synthetic magnitude inversion-recovery (IR) and phase-sensitive IR (PSIR) images were generated through calculations based on the post-contrast T1-mapping sequence. Three cardiothoracic radiologists independently analyzed the image quality of conventional and synthetic LGE images on an ordinal scale with per-segment basis and the image qualities were compared with chi-square test. The agreement of LGE detection was analyzed on per-patient and per-segment basis with Cohen’s kappa test. In addition, the LGE area and percentage were semi-quantitatively analyzed for LGE positive ischemic (n = 14) and hypertrophic cardiomyopathy (n = 13) subgroups by two cardiothoracic radiologists. The difference of quantified LGE area and percentage between conventional and synthetic LGE images were assessed with Mann–Whitney U-test and the inter-reader agreement was assessed with Bland–Altman analysis. Results The image quality of synthetic images was significantly better than conventional images in both magnitude IR and PSIR through all three observers (P < 0.001, all). The agreements of per-patient and per-segment LGE detection rates were excellent (kappa = 0.815–0.864). The semi-quantitative analysis showed no significant difference in the LGE area and percentage between conventional and synthetic LGE images. In the inter-reader agreement showed only small systematic differences in both magnitude IR and PSIR and synthetic LGE images showed smaller systematic biases compared to conventional LGE images. Conclusion Compared to conventional LGE images, synthetic LGE images have better image quality in real-life clinical situation.

show abstract

Section: Discussionmentioning

confidence: 99%

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

Lee

Kim

et al. 2022

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

show abstract

“…A normalized ratio of signal intensity in the RV cavity compared with the LV cavity was defined as

italicRV - italicto - L V_{ratio} = 1 + \frac{italicRV - italicLV}{italicMyo - italicLV} .

With this definition, images with no difference in signal intensity between the LV and RV blood‐pools ( LV and RV , respectively) will have a RV‐to‐LV ratio of 1, and when the RV blood‐pool is as bright as normal myocardium ( Myo ), the RV‐to‐LV ratio will be 2. This definition was used rather than a simple ratio of signal intensity because FIDDLE images are reconstructed using the PSIR algorithm, which adds a baseline offset signal to allow for rectification of the polarity of magnetization 16 . Our definition removes the effect of the baseline offset and provides a ratio which is normalized to the signal difference between normal myocardium and LV blood‐pool.…”

Section: Methodsmentioning

confidence: 99%

Comparison of magnetization transfer‐preparation and T2‐preparation for dark‐blood delayed‐enhancement imaging

et al. 2020

Self Cite

View full text Add to dashboard Cite

Recently developed dark-blood techniques such as Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrastenhancement and blood-pool suppression. Critical to FIDDLE is the magnetization preparation, which accentuates differences between myocardium and blood-pool. Here, we compared magnetization transfer (MT)-preparation and T2-preparation for use with FIDDLE. Variants of FIDDLE were developed with MT-or T2-preparation modules and tested in 35 patients (11 at 1.5 T, 24 at 3 T). Images were acquired with each FIDDLE variant in an interleaved fashion 10 minutes after gadolinium administration with otherwise identical acquisition parameters. Images were visually and quantitatively assessed for artifacts and differences in right ventricle to left ventricle (RV-to-LV) blood-pool suppression. Bright artifacts, reflecting incomplete blood-pool suppression, were frequently observed in the left atrium with T2-preparation FIDDLE at 1.5 and 3 T (82% and up to 100% of patients, respectively). MT-preparation

show abstract

“…Since LGE cannot distinguish between amyloid deposition and fibrosis, it is possible that a patchy amyloid infiltration can look similar to diffuse fibrosis [39]. Another indicative finding of CA are ghosting artefacts which are commonly found and caused by effusions [40,41]. Perhaps one of the biggest advantages of CMR is the exclusion of differential diagnoses which also cause LV hypertrophy, such as hypertrophic cardiomyopathy, Fabry's disease and hemochromatosis [42].…”

Section: K Short Reviewmentioning

confidence: 99%

Diagnosis and supportive therapeutic management of cardiac light chain amyloidosis—a cardiologist’s perspective

Binder

Duca

2021

memo

View full text Add to dashboard Cite

SummaryCardiac amyloidosis is caused by deposition of abnormally folded proteins (amyloid). The most common forms of amyloidosis which present with cardiac involvement are light-chain amyloidosis (AL) and transthyretin amyloidosis (ATTR). Even with novel treatments emerging, the prognosis of these patients remains poor once amyloid deposits in the heart. Therefore, knowledge on clinical and imaging features of cardiac amyloidosis is crucial to make an early diagnosis and improve patient outcomes. This article reviews the most important diagnostic findings of cardiac amyloidosis and gives an overview on the therapeutic management of these patients, including supportive-, device- and disease-specific drug therapies focusing on AL amyloidosis.

show abstract

Suppression of ghost artifacts arising from long T₁ species in segmented inversion‐recovery imaging

Abstract: We developed and validated a new robust method, SPPRESS, for reducing artifacts due to long T species across a wide range of imaging and physiologic conditions. Magn Reson Med 78:1442-1451, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Cited by 8 publications

References 13 publications

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

Comparison of magnetization transfer‐preparation and T2‐preparation for dark‐blood delayed‐enhancement imaging

Diagnosis and supportive therapeutic management of cardiac light chain amyloidosis—a cardiologist’s perspective

Contact Info

Product

Resources

About

Suppression of ghost artifacts arising from long T1 species in segmented inversion‐recovery imaging

Abstract: We developed and validated a new robust method, SPPRESS, for reducing artifacts due to long T species across a wide range of imaging and physiologic conditions. Magn Reson Med 78:1442-1451, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Cited by 8 publications

References 13 publications

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

The image quality and diagnostic accuracy of T1-mapping-based synthetic late gadolinium enhancement imaging: comparison with conventional late gadolinium enhancement imaging in real-life clinical situation

Comparison of magnetization transfer‐preparation and T2‐preparation for dark‐blood delayed‐enhancement imaging

Diagnosis and supportive therapeutic management of cardiac light chain amyloidosis—a cardiologist’s perspective

Contact Info

Product

Resources

About

Suppression of ghost artifacts arising from long T₁ species in segmented inversion‐recovery imaging