Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

Boffa, Lidia C.; Vidali, G.; Mann, Robert S.; Allfrey, Vincent G.

doi:10.1016/s0021-9258(17)34804-4

Cited by 420 publications

(43 citation statements)

References 28 publications

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“…HDACs are subdivided into two protein subfamilies, which differ in protein structure and mechanism of action: the classical HDAC family and the sirtuins family [103]. The pharmacological compounds SRT1720 and EX-527 were designed to inhibit sirtuins [84,90], whereas sodium butyrate [104], Trichostatin A [85], valproic acid [105], and D-βhydroxybutyrate [101] inhibit the classic HDACs. Given that the same intergenerational effects were obtained with compounds that interfere with different subfamilies of HDACs, which may also have different target proteins, these results would suggest that the effects are not direct.…”

Section: Discussionmentioning

confidence: 99%

Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

et al. 2021

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Background Environmental stimuli experienced by the parental generation influence the phenotype of subsequent generations (Demoinet et al., Proc Natl Acad Sci U S A 114:E2689-E2698, 2017; Burton et al., Nat Cell Biol 19:252–257, 2017; Agrawal et al., Nature 401:60-63, 1999). The effects of these stimuli on the parental generation may be passed through the germline, but the mechanisms at the basis of this non-Mendelian type of inheritance, their level of conservation, how they lead to adaptive vs non-adaptive, and intergenerational vs transgenerational inheritance are poorly understood. Here we show that modulation of nutrient-sensing pathways in the parental generation of the nematode Auanema freiburgensis regulates phenotypic plasticity of its offspring. Results In response to con-specific pheromones indicative of stress, AMP-activated protein kinase (AMPK), mechanistic target of rapamycin complex 1 (mTORC1), and insulin signaling regulate stress resistance and sex determination across one generation, and these effects can be mimicked by pathway modulators. The effectors of these pathways are closely associated with the chromatin, and their regulation affects the chromatin acetylation status in the germline. Conclusion These results suggest that highly conserved metabolic sensors regulate phenotypic plasticity through regulation of subcellular localization of their effectors, leading to changes in chromatin acetylation and epigenetic status of the germline.

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Section: Discussionmentioning

confidence: 99%

Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

et al. 2021

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“…Among them, the classical ones are a new promising class of targets of drugs against cancers. Sodium butyrate is a fatty acid and acts as an HDAC inhibitor in some studies [21][22][23]. Diabetes seems to significantly influence the function of the kidney according to the evidence that diabetes was associated with enhanced plasma urea and creatinine levels, while significant changes of total protein, plasma albumin and relative kidney weight were not found.…”

Section: Discussionmentioning

confidence: 99%

LINC00162 participates in the pathogenesis of diabetic nephropathy via modulating the miR-383/HDAC9 signalling pathway

Fan

Wen

JinFeng

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…Although our results indicate that SCFAs regulate ClC-2 activity directly, an SCFA-dependent mechanism involving G-coupled receptors cannot be ruled out. Indeed, SCFAs not only act as energy sources [37] and histone deacetylase inhibitors [38] in enterocytes but also bind and stimulate G-coupled receptors [39]. GPR41, GPR43, and GPR109A are G-coupled receptors expressed in several cell types, including intestinal epithelial cells that are activated by SCFAs in the concentration range found in the intestinal lumen [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action

Catalán

Julio‐Kalajzić

Niemeyer

et al. 2020

Cells

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Lubiprostone, a 20-carbon synthetic fatty acid used for the treatment of constipation, is thought to act through an action on Cl− channel ClC-2. Short chain fatty acids (SCFAs) are produced and absorbed in the distal intestine. We explore whether SCFAs affect ClC-2, re-examine a possible direct effect of lubiprostone on ClC-2, and use mice deficient in ClC-2 to stringently address the hypothesis that the epithelial effect of lubiprostone targets this anion channel. Patch-clamp whole cell recordings of ClC-2 expressed in mammalian cells are used to assay SCFA and lubiprostone effects. Using chamber measurements of ion current in mice deficient in ClC-2 or CFTR channels served to analyze the target of lubiprostone in the distal intestinal epithelium. Intracellular SCFAs had a dual action on ClC-2, partially inhibiting conduction but, importantly, facilitating the voltage activation of ClC-2. Intra- or extracellular lubiprostone had no effect on ClC-2 currents. Lubiprostone elicited a secretory current across colonic epithelia that was increased in mice deficient in ClC-2, consistent with the channel’s proposed proabsorptive function, but absent from those deficient in CFTR. Whilst SCFAs might exert a physiological effect on ClC-2 as part of their known proabsorptive effect, ClC-2 plays no part in the lubiprostone intestinal effect that appears mediated by CFTR activation.

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Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

Cited by 420 publications

References 28 publications

Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

LINC00162 participates in the pathogenesis of diabetic nephropathy via modulating the miR-383/HDAC9 signalling pathway

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action

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