In order to reduce the power of methane explosion in natural gas pipelines and effectively improve the explosion suppression efficiency of a single explosion suppressant, we carry out the explosion suppression of HFC‐227ea/carbon dioxide mixed gas as well as mixed gas/ultrafine water mist through a self‐built methane explosion suppression experimental platform. Based on the changes in parameters such as explosion overpressure, flame propagation velocity, and flame propagation structure, the coupling mechanism of methane explosion suppression between mixed gases and between mixed gases and ultrafine water mist is revealed, which provides scientific support for promoting the development of methane explosion suppression technology. The experimental results show that when the mixed gas HFC‐227ea/carbon dioxide and ultrafine water mist synergistically suppresses methane explosion, the addition of the mixed gas can effectively improve the suppression effect of ultrafine water mist on methane explosion.