Suppression of Immunoglobulin Production by Germinal Centre HNK-1+ CD3+ Cells

Banerjee, Diponkar; Baril, Jean-Guy; Bell, David A.; McFarlane, David L.; Karim, Rubina

doi:10.1007/978-1-4684-5535-9_64

Cited by 3 publications

(2 citation statements)

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“…The microarray study also revealed that CD57 + GC-Th cells have the unique capacity to produce CXCL13, a follicle chemokine implicated in recruitment of CXCR5 + cells [22,23] and development of follicles/GCs [24]. Because of their specific localization in germinal centers, the activities of CD57 + GC-Th cells on B cell proliferation and antibody production have been studied by several groups of scientists [19,25-27]. The results of these previous studies reveled unique features of CD57 + GC-Th cells, but, when combined, they are inconclusive and widely vary from negative to neutral or positive in assessing the helper activities of CD57 + GC-Th cells.…”

Section: Introductionmentioning

confidence: 99%

Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination

Kim¹,

Lim

Kang³

et al. 2005

BMC Immunol

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Background: The function of CD57 + CD4 + T cells, constituting a major subset of germinal center T (GC-Th) cells in human lymphoid tissues, has been unclear. There have been contradictory reports regarding the B cell helping function of CD57 + GC-Th cells in production of immunoglobulin (Ig). Furthermore, the cytokine and co-stimulation requirement for their helper activity remains largely unknown. To clarify and gain more insight into their function in helping B cells, we systematically investigated the capacity of human tonsil CD57 + GC-Th cells in inducing B cell Ig synthesis.

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Section: Introductionmentioning

confidence: 99%

Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination

Kim¹,

Lim

Kang³

et al. 2005

BMC Immunol

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show abstract

“…Although expressing HNK-1 (CD57), which was initially thought to be human natural killer cell specific, these cells were not cytotoxically active. Under certain circumstances, we found that these cells could either suppress or enhance immunoglobulin production by pokeweed mitogen-activated tonsillar B cells (Banerjee, D. et al, 1988). Such cells are now recognized to be specialized CD4+ T cells called follicular helper T cells (T FH ) that home to the germinal center and play a pivotal role in regulating the fate of B cell in the germinal centre reaction.…”

Section: The Role Of the Follicular Helper T Cell (T Fh )mentioning

confidence: 99%