Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma lucidum

Bhardwaj, Neha; Katyal, Priya; Sharma, Anil Kumar

doi:10.2174/1872213x08666140619110657

Cited by 42 publications

(21 citation statements)

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“…Ganoderma lucidum has been reported to have wide effects in suppressing inflammation 48 and increases the activity of SOD in cerebral IR 7 . MPO is a characteristic constituent of neutrophil granules and represents ROS-related inflammation.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Zhong

Wang

Liu

et al. 2015

Sci Rep

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Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). The aim of this study was to determine whether GLPP could attenuate RIRI by counteracting the oxidative stress. The mechanism involved was assessed by an in vivo mouse RIRI model and an in vitro hypoxia/reoxygenation model, and tunicamycin-stimulated NRK-52E cells were used to explore the GLPP-mediated alleviation of ER stress. Experimental results showed that renal dysfunction and morphological damage were reduced in GLPP-treated group. The imbalance of redox status was reversed and production of ROS was reduced by GLPP. RIRI-induced mitochondrial- and ER stress-dependent apoptosis were dramatically inhibited in GLPP-treated group. Intriguingly, JNK activation in the kidney with RIRI or hypoxia/reoxygenation was inhibited by GLPP. These results suggest that the protective effect of GLPP against RIRI may be due to reducing oxidative stress, alleviating the mitochondrial and ER stress-dependent apoptosis caused by excessive ROS.

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Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Zhong

Wang

Liu

et al. 2015

Sci Rep

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“…36–38 We have shown that G. lucidum , a key herbal constituent in FAHF-2 and ASHMI, has anti-inflammatory effects on cytokines involved in both allergic and non-allergic disorders. 39–41 …”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohnʼs Disease Associated with Downregulation of NF-κB Signaling

Liu

Dunkin

Lai

et al. 2015

Inflammatory Bowel Diseases

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Background Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Current medications have potentially serious side effects. Hence there is increasing interest in alternative therapies. We previously demonstrated the anti-inflammatory effects of FAHF-2 in-vitro on PBMCs and mucosa from CD subjects. Here we investigated the anti-inflammatory effects of a bioactive compound isolated from Ganoderma lucidum (G. lucidum), a key herbal constituent of FAHF-2, in CD in vitro. Methods Triterpene ganoderic acid C1 (GAC1) was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with GAC1. Human peripheral blood mononuclear cells (PBMCs) and colonic biopsies were obtained from children with CD and cultured with or without GAC1. TNF-α and other pro-inflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with GAC1 by In-Cell Western and western blot analysis. Results GAC1 decreased TNF-α production by macrophages and PBMCs from CD subjects. GAC1 significantly decreased TNF-α, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to down-regulation of the NF-κB signaling pathway. Conclusions GAC1 inhibited production of TNF-α and other pro-inflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation. GAC1 is a key beneficial constituent in G. lucidum and the FAHF-2 formula in suppressing the inflammatory cytokines found in CD and warrants clinical investigation for the treatment of CD.

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“… 141 In addition, G. lucidum exhibits anti-inflammatory and immunomodulatory effects. 58 The healthy aging mechanism of G. lucidum may be related to Nrf2, mTOR and MAPK pathways. A previous study has shown that G. lucidum treatment induces the expression of Nrf2, while transfection with Nrf2 siRNA attenuates its protection effects.…”

Section: Therapeutic Drugs Targeting Senescencementioning

confidence: 99%

Advancements in therapeutic drugs targeting of senescence

Zhu

Meng

Ling

et al. 2020

Therapeutic Advances in Chronic Disease

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Aging leads to a high burden on society, both medically and economically. Cellular senescence plays an essential role in the initiation of aging and age-related diseases. Recent studies have highlighted the therapeutic value of senescent cell deletion in natural aging and many age-related disorders. However, the therapeutic strategies for manipulating cellular senescence are still at an early stage of development. Among these strategies, therapeutic drugs that target cellular senescence are arguably the most highly anticipated. Many recent studies have demonstrated that a variety of drugs exhibit healthy aging effects. In this review, we summarize different types of drugs promoting healthy aging – such as senolytics, senescence-associated secretory phenotype (SASP) inhibitors, and nutrient signaling regulators – and provide an update on their potential therapeutic merits. Taken together, our review synthesizes recent advancements in the therapeutic potentialities of drugs promoting healthy aging with regard to their clinical implications.

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Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma lucidum

Cited by 42 publications

References 0 publications

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohnʼs Disease Associated with Downregulation of NF-κB Signaling

Advancements in therapeutic drugs targeting of senescence

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