Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways

Limtrakul, Pornngarm; Yodkeeree, Supachai; Pitchakarn, Pornsiri; Punfa, Wanisa

doi:10.7314/apjcp.2015.16.10.4277

Cited by 86 publications

(73 citation statements)

References 31 publications

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“…Limtrakul et al . (, ) reported that red and black rice extracts even at a higher concentration of 200 μg mL −1 had no significant effect on the cell viability of the macrophage cell. Also, Petroni et al .…”

Section: Resultsmentioning

confidence: 97%

“…The presence of some polyphenolic compounds in the purple rice extracts mainly contributes to the cell viability and proliferation of the RAW 264.7 murine macrophage cells. Limtrakul et al (2016Limtrakul et al ( , 2015 reported that red and black rice extracts even at a higher concentration of 200 lg mL À1 had no significant effect on the cell viability of the macrophage cell. Also, Petroni et al (2017) observed no growth effects on the macrophage cells with red and black rice extracts (125 lM).…”

Section: Assessment Of Cell Viability and No Production Inhibition Inmentioning

confidence: 99%

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Bioactive components, antioxidative and anti‐inflammatory properties (on RAW 264.7 macrophage cells) of soaked and germinated purple rice extracts

Owolabi

Chakree

Yupanqui

2019

Int J of Food Sci Tech

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Summary The bioactive components, antioxidative properties and phenolic profile of Thai purple rice after 24 h soaking and 36 h germination periods were investigated. Anti‐inflammatory properties of the rice extracts were also evaluated on macrophage cells, stimulated with Lipopolysaccharide. These conditions significantly increased the bioactive components and antioxidative properties. Total anthocyanin contents, total carotenoid contents and gamma‐aminobutyric acid were increased more than twofold in the soaked sample. Protocatechuic, caffeic, p‐coumaric, ferullic, rutin trihydrate, catechin and Trans‐cinnamic acids were detected in the extracts. Gallic acid was only identified after soaking and germination. All the extracts led to cell proliferation and inhibited nitric oxide (NO) production. Twenty‐four hour soaking exhibited highest bioactive compounds, antioxidative properties and showed greater NO inhibitory effects with IC50 of 234.00 ± 0.01 μg mL−1. In addition to established information on germination, soaking greatly improved the bioactive components and anti‐inflammatory properties of the rice variety.

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Section: Resultsmentioning

confidence: 97%

Section: Assessment Of Cell Viability and No Production Inhibition Inmentioning

confidence: 99%

Bioactive components, antioxidative and anti‐inflammatory properties (on RAW 264.7 macrophage cells) of soaked and germinated purple rice extracts

Owolabi

Chakree

Yupanqui

2019

Int J of Food Sci Tech

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“…To identify the molecular mechanisms involved in this reduction of the inflammatory tone in adipose tissue, we evaluated the effect of lycopene and TP on the phosphorylation of p65 and IκB, two actors of the NF‐κB signaling pathway . We observed that lycopene and TP strongly reduced the phosphorylation levels of p65 and IκB.…”

Section: Discussionmentioning

confidence: 98%

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders

Fenni

Hammou

Astier

et al. 2017

Mol. Nutr. Food Res.

119

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Scope: Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity associated disorders. Methods and results:Male C57BL/J6 mice were assigned into 4 groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight. Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes. Lycopene and TP decreased HFD-induced pro-inflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue. The antiinflammatory effect of lycopene and TP was related to a reduction in the phosphorylation levels of IκB, and p65, and resulted in a decrease of inflammatory proteins in adipose tissue Conclusion:These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies.

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“…In addition, CuE remained in the medium throughout the experiments, but the cytokines persistent. That might be due to the duration of cytokines accumulation is limited by several feedback mechanisms, such as the induction of JNK, AP-1 or other signal pathways [35,36]. That might be the reason why the broad spectrum of antirheumatic drugs used for RA treatment, this heterogeneous disease is still not well controlled.…”

Section: Discussionmentioning

confidence: 99%

Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways

Jia

Cheng

Yue

et al. 2015

International Immunopharmacology

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Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways

Cited by 86 publications

References 31 publications

Bioactive components, antioxidative and anti‐inflammatory properties (on RAW 264.7 macrophage cells) of soaked and germinated purple rice extracts

Bioactive components, antioxidative and anti‐inflammatory properties (on RAW 264.7 macrophage cells) of soaked and germinated purple rice extracts

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders

Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways

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