Suppression of Lymphocyte Stimulation Following Bereavement

Schleifer, Steven J.; Keller, Steven E.; Camerino, Maria; Thornton, John C.; Stein, Mary Kay

doi:10.1001/jama.1983.03340030034024

Cited by 512 publications

(118 citation statements)

References 17 publications

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“…Bereavement has been associated with in vitro functional immune measures such as decreased natural killer cell cytotoxicity and poorer lymphocyte proliferation to mitogen (Bartrop et al, 1977;Goodkin et al, 1996;Irwin et al, 1987;Kemeny et al, 1995;Schleifer et al, 1983;Zisook et al, 1994). The present findings regarding marital status and satisfaction also extend the results of previous studies showing that poorer marital quality, in terms of adjustment and negative marital interactions, are associated with inferior functional immunity evidenced through reduced proliferation to some mitogens, poorer latent virus control (Kiecolt- Glaser et al, 1987;Kiecolt-Glaser et al, 1997;Kiecolt-Glaser et al, 1988;Kiecolt-Glaser et al, 1993), and weaker natural killer cell cytotoxicity (Miller et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Phillips

Carroll

Burns

et al. 2006

Brain, Behavior, and Immunity

101

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Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N = 184). Antibody response was assessed at baseline, and at one and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains.However, bereavement in the year prior to vaccination was negatively associated with the one-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at one month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples.This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group.

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Section: Discussionmentioning

confidence: 99%

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Phillips

Carroll

Burns

et al. 2006

Brain, Behavior, and Immunity

101

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show abstract

“…More chronic conditions, such as divorce (Kiecolt-Glaser, Fisher, et al, 1987), bereavement (Schleifer, Keller, Camerino, Thornton, & Stein, 1983), and Alzheimer caregiving , also alter measures of immunity. The literature demonstrating these links has been the subject of numerous recent reviews (Ader & Cohen, 1993;Cohen & Williamson, 1991;Weiner, 1991) and will not be reviewed here yet again.…”

Section: Stress and Immunitymentioning

confidence: 99%

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

326

168

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Psychoneuroimmunology is the study of interactions between behavior, the brain, and the immune system. This article is designed to provide an overview of this new field for the general psychologist. The existence of bidirectional communication pathways between the brain and the immune system and the implications of this network for behavior are emphasized. Implications are that behavioralpsychological processes ought to be capable of altering immune function and that events that occur as part of immune responses should modulate behavior. Evidence for influences in both of these directions is reviewed. The discussion of psychological modulation of immunity focuses on classical conditioning and stress, whereas that of immune modification of behavior highlights behavioral effects produced by substances released by the immune system. Finally, the adaptive role that such changes might play is considered. Lyle E. Bourne served as action editor for this article.

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“…In vitro measures of immune function, such as lymphocyte proliferation to mitogen, have also been shown to be susceptible to stress-induced alterations [12,[20][21][22][23][24][25][26]. These functional assays give a better indication of immune status than the enumerative methods, as proliferation in response to antigen is a key component of the immune response.…”

Section: Introductionmentioning

confidence: 99%

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymusdependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

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Suppression of Lymphocyte Stimulation Following Bereavement

Cited by 512 publications

References 17 publications

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

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