Suppression of myofilament cross-bridge kinetic in the heart of orchidectomized rats

Wadthaisong, Munthana; Wattanapermpool, Jonggonnee; Tombe, Pieter P. de; Bupha-Intr, Tepmanas

doi:10.1016/j.lfs.2020.118342

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Decreased testosterone also has been shown to modify myofilament function, inducing prolonged relaxation and diastolic dysfunction in aged animals [ 62 ] . In line with this, orchiectomized male rats demonstrate decreased active force and slower cross-bridge cycling with higher expression of beta-myosin heavy chain and lower phosphorylation of key sarcomeric proteins [ 69 ] . However, an important consideration is that the majority of the sex hormone studies have been completed in adult or young animals and not in old animals.…”

Section: Cardiac Aging In Men and Womenmentioning

confidence: 91%

“…Moreover, numerous reports suggest that myofilament proteins are differentially modified in males and females with age [ 54 ] . It is clear that sex hormones differentially impact myofilament function [ 62 – 69 ] . However, reports are conflicting with the overall effect of estradiol itself on myofilament function and modifications.…”

Section: Cardiac Aging In Men and Womenmentioning

confidence: 99%

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Mechanisms and implications of sex differences in cardiac aging

Yusifov¹,

Woulfe²,

Bruns³

2022

JCA

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Aging promotes structural and functional remodeling of the heart, even in the absence of external factors. There is growing clinical and experimental evidence supporting the existence of sex-specific patterns of cardiac aging, and in some cases, these sex differences emerge early in life. Despite efforts to identify sex-specific differences in cardiac aging, understanding how these differences are established and regulated remains limited. In addition to contributing to sex differences in age-related heart disease, sex differences also appear to underlie differential responses to cardiac stress such as adrenergic activation. Identifying the underlying mechanisms of sex-specific differences may facilitate the characterization of underlying heart disease phenotypes, with the ultimate goal of utilizing sex-specific therapeutic approaches for cardiac disease. The purpose of this review is to discuss the mechanisms and implications of sex-specific cardiac aging, how these changes render the heart more susceptible to disease, and how we can target age- and sex-specific differences to advance therapies for both male and female patients.

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Section: Cardiac Aging In Men and Womenmentioning

confidence: 91%

Section: Cardiac Aging In Men and Womenmentioning

confidence: 99%

Mechanisms and implications of sex differences in cardiac aging

Yusifov¹,

Woulfe²,

Bruns³

2022

JCA

View full text Add to dashboard Cite

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Considering impact of age and sex on cardiac cytoskeletal components

Jones,

Woulfe

2024

American Journal of Physiology-Heart and Circulatory Physiology

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The cardiac cytoskeletal components are integral to cardiomyocyte function and are responsible for contraction, sustaining cell structure, and providing scaffolding to direct signaling. Cytoskeletal components have been implicated in cardiac pathology; however, less attention has been paid to age-related modifications of cardiac cytoskeletal components and how these contribute to dysfunction with increased age. Moreover, significant sex differences in cardiac aging have been identified, but we still lack a complete understanding to the mechanisms behind these differences. This review summarizes what is known about how key cardiomyocyte cytoskeletal components are modified due to age, as well as reported sex-specific differences. Thorough consideration of both age and sex as integral players in cytoskeletal function may reveal potential avenues for more personalized therapeutics.

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Suppression of myofilament cross-bridge kinetic in the heart of orchidectomized rats

Cited by 2 publications

References 48 publications

Mechanisms and implications of sex differences in cardiac aging

Mechanisms and implications of sex differences in cardiac aging

Considering impact of age and sex on cardiac cytoskeletal components

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