2005
DOI: 10.1038/sj.onc.1208656
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Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells

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Cited by 289 publications
(217 citation statements)
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“…Accordingly, inhibition of NF-kB may not always be associated with increased induction of apoptosis but also may contribute to apoptosis reduction. These observations should be carefully taken into account for applications of chemotherapeutics, especially in combination therapies with cytokines or NF-kB-inhibiting compounds (Sclabas et al, 2005;Xu et al, 2005;Zavarski et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, inhibition of NF-kB may not always be associated with increased induction of apoptosis but also may contribute to apoptosis reduction. These observations should be carefully taken into account for applications of chemotherapeutics, especially in combination therapies with cytokines or NF-kB-inhibiting compounds (Sclabas et al, 2005;Xu et al, 2005;Zavarski et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…that SFN did not block IB/ degradation or nuclear import of the NF-B subunits p50 (NF-B1) and p65 (RelA), but could directly interfere with NF-B DNA binding in vitro [41]. By contrast, others have shown that ITCs reduce phosphorylation and increase expression of IB [42][43][44]46]. SFN and PEITC inhibited IKK-mediated phosphorylation of IB in an in vitro assay, suggesting that IKK may be a direct target for modulation by ITCs [44].…”
Section: Hif-independent Control Of Angiogenesismentioning
confidence: 93%
“…45,48 Additionally, small molecule Nrf2 activators have been shown to be effective in inhibiting activation of NF-jB. Xu et al 49 demonstrated that sulforaphane exposure to a human prostate cancer cell line resulted in decreased UVCinduced NF-jB activation. Likewise, administration of 3H-1,2-dithiole-3-thione to rats inhibited LPS-induced NF-jB activation by decreasing IjBa phosphorylation and degradation.…”
Section: Discussionmentioning
confidence: 99%